@article{mathur_influence_1979,
	title = {Influence of zinc on onset and progression of oral carcinogenesis in rats},
	volume = {37},
	issn = {0001-6357},
	doi = {10.3109/00016357909004697},
	abstract = {Three-week-old female rats were fed 0.09 (zinc-deficient), 0.77 (zinc-adequate) or 3.98 (zinc-supplemented) mmol zinc/kg diet in three experimental groups and the palatal mucosa was painted with the water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) three times a week for 20 weeks. The zinc-supplemented diet seemed to retard the induction of carcinogenesis, whereas a low-zinc diet had the opposite effect. Once initial cellular changes had been induced the supplementary zinc seemed to accelerate their further advancement. Zinc-deficiency in animals fed a copper/zinc low-zinc diet was reflected in the plasma and liver zinc levels as well as in the copper/zinc ratio. The development of cancer was accompanied by a decrease in plasma zinc and an increase in the plasma copper/zinc ratio as well as in the liver zinc. These changes were most remarkable in the zinc-supplemented group.},
	language = {eng},
	number = {5},
	journal = {Acta Odontologica Scandinavica},
	author = {Mathur, A. and Wallenius, K. and Abdulla, M.},
	year = {1979},
	pmid = {118633},
	keywords = {4-Nitroquinoline-1-oxide, Animals, Copper, Female, Male, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Experimental, Palate, Soft, Rats, Zinc},
	pages = {277--284},
}

{"_id":"4AARZcJtCCg8L9ZJ3","bibbaseid":"mathur-wallenius-abdulla-influenceofzincononsetandprogressionoforalcarcinogenesisinrats-1979","author_short":["Mathur, A.","Wallenius, K.","Abdulla, M."],"bibdata":{"bibtype":"article","type":"article","title":"Influence of zinc on onset and progression of oral carcinogenesis in rats","volume":"37","issn":"0001-6357","doi":"10.3109/00016357909004697","abstract":"Three-week-old female rats were fed 0.09 (zinc-deficient), 0.77 (zinc-adequate) or 3.98 (zinc-supplemented) mmol zinc/kg diet in three experimental groups and the palatal mucosa was painted with the water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) three times a week for 20 weeks. The zinc-supplemented diet seemed to retard the induction of carcinogenesis, whereas a low-zinc diet had the opposite effect. Once initial cellular changes had been induced the supplementary zinc seemed to accelerate their further advancement. Zinc-deficiency in animals fed a copper/zinc low-zinc diet was reflected in the plasma and liver zinc levels as well as in the copper/zinc ratio. The development of cancer was accompanied by a decrease in plasma zinc and an increase in the plasma copper/zinc ratio as well as in the liver zinc. These changes were most remarkable in the zinc-supplemented group.","language":"eng","number":"5","journal":"Acta Odontologica Scandinavica","author":[{"propositions":[],"lastnames":["Mathur"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Wallenius"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Abdulla"],"firstnames":["M."],"suffixes":[]}],"year":"1979","pmid":"118633","keywords":"4-Nitroquinoline-1-oxide, Animals, Copper, Female, Male, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Experimental, Palate, Soft, Rats, Zinc","pages":"277–284","bibtex":"@article{mathur_influence_1979,\n\ttitle = {Influence of zinc on onset and progression of oral carcinogenesis in rats},\n\tvolume = {37},\n\tissn = {0001-6357},\n\tdoi = {10.3109/00016357909004697},\n\tabstract = {Three-week-old female rats were fed 0.09 (zinc-deficient), 0.77 (zinc-adequate) or 3.98 (zinc-supplemented) mmol zinc/kg diet in three experimental groups and the palatal mucosa was painted with the water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) three times a week for 20 weeks. The zinc-supplemented diet seemed to retard the induction of carcinogenesis, whereas a low-zinc diet had the opposite effect. Once initial cellular changes had been induced the supplementary zinc seemed to accelerate their further advancement. Zinc-deficiency in animals fed a copper/zinc low-zinc diet was reflected in the plasma and liver zinc levels as well as in the copper/zinc ratio. The development of cancer was accompanied by a decrease in plasma zinc and an increase in the plasma copper/zinc ratio as well as in the liver zinc. These changes were most remarkable in the zinc-supplemented group.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Acta Odontologica Scandinavica},\n\tauthor = {Mathur, A. and Wallenius, K. and Abdulla, M.},\n\tyear = {1979},\n\tpmid = {118633},\n\tkeywords = {4-Nitroquinoline-1-oxide, Animals, Copper, Female, Male, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Experimental, Palate, Soft, Rats, Zinc},\n\tpages = {277--284},\n}\n\n","author_short":["Mathur, A.","Wallenius, K.","Abdulla, M."],"key":"mathur_influence_1979","id":"mathur_influence_1979","bibbaseid":"mathur-wallenius-abdulla-influenceofzincononsetandprogressionoforalcarcinogenesisinrats-1979","role":"author","urls":{},"keyword":["4-Nitroquinoline-1-oxide","Animals","Copper","Female","Male","Mouth Mucosa","Mouth Neoplasms","Neoplasms","Experimental","Palate","Soft","Rats","Zinc"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/46698/items?key=ubq1R9YBMh4WxLV9o11xNG5E&format=bibtex&limit=100","dataSources":["cu4XGPYKkkiADwGRC"],"keywords":["4-nitroquinoline-1-oxide","animals","copper","female","male","mouth mucosa","mouth neoplasms","neoplasms","experimental","palate","soft","rats","zinc"],"search_terms":["influence","zinc","onset","progression","oral","carcinogenesis","rats","mathur","wallenius","abdulla"],"title":"Influence of zinc on onset and progression of oral carcinogenesis in rats","year":1979}