Transient compartmentalization of RNA replicators prevents extinction due to parasites. Matsumura, S., Kun, Á., Ryckelynck, M., Coldren, F., Szilágyi, A., Jossinet, F., Rick, C., Nghe, P., Szathmáry, E., & Griffiths, A. D. Science, 354(6317):1293--1296, December, 2016. 00014
Transient compartmentalization of RNA replicators prevents extinction due to parasites [link]Paper  doi  abstract   bibtex   
Beating the curse of the parasite The evolution of molecular replicators was a critical step in the origin of life. Such replicators would have suffered from faster-replicating “molecular parasites” outcompeting the parental replicator. Compartmentalization of replicators inside protocells would have helped ameliorate the effect of parasites. Matsumura et al. show that transient compartmentalization in nonbiological materials is sufficient to tame the problem of parasite takeover. They analyzed viral replication in a droplet-based microfluidic system, which revealed that as long as there is selection for a functional replicator, the population is not overwhelmed by the faster-replicating parasite genomes. Science, this issue p. 1293 The appearance of molecular replicators (molecules that can be copied) was probably a critical step in the origin of life. However, parasitic replicators would take over and would have prevented life from taking off unless the replicators were compartmentalized in reproducing protocells. Paradoxically, control of protocell reproduction would seem to require evolved replicators. We show here that a simpler population structure, based on cycles of transient compartmentalization (TC) and mixing of RNA replicators, is sufficient to prevent takeover by parasitic mutants. TC tends to select for ensembles of replicators that replicate at a similar rate, including a diversity of parasites that could serve as a source of opportunistic functionality. Thus, TC in natural, abiological compartments could have allowed life to take hold. Temporary compartmentalization in water drops prevents molecular replicators from being swamped by faster-replicating parasitic mutants. Temporary compartmentalization in water drops prevents molecular replicators from being swamped by faster-replicating parasitic mutants.
@article{matsumura_transient_2016,
	title = {Transient compartmentalization of {RNA} replicators prevents extinction due to parasites},
	volume = {354},
	copyright = {Copyright © 2016, American Association for the Advancement of Science},
	issn = {0036-8075, 1095-9203},
	url = {http://science.sciencemag.org/content/354/6317/1293},
	doi = {10.1126/science.aag1582},
	abstract = {Beating the curse of the parasite
The evolution of molecular replicators was a critical step in the origin of life. Such replicators would have suffered from faster-replicating “molecular parasites” outcompeting the parental replicator. Compartmentalization of replicators inside protocells would have helped ameliorate the effect of parasites. Matsumura et al. show that transient compartmentalization in nonbiological materials is sufficient to tame the problem of parasite takeover. They analyzed viral replication in a droplet-based microfluidic system, which revealed that as long as there is selection for a functional replicator, the population is not overwhelmed by the faster-replicating parasite genomes.
Science, this issue p. 1293
The appearance of molecular replicators (molecules that can be copied) was probably a critical step in the origin of life. However, parasitic replicators would take over and would have prevented life from taking off unless the replicators were compartmentalized in reproducing protocells. Paradoxically, control of protocell reproduction would seem to require evolved replicators. We show here that a simpler population structure, based on cycles of transient compartmentalization (TC) and mixing of RNA replicators, is sufficient to prevent takeover by parasitic mutants. TC tends to select for ensembles of replicators that replicate at a similar rate, including a diversity of parasites that could serve as a source of opportunistic functionality. Thus, TC in natural, abiological compartments could have allowed life to take hold.
Temporary compartmentalization in water drops prevents molecular replicators from being swamped by faster-replicating parasitic mutants.
Temporary compartmentalization in water drops prevents molecular replicators from being swamped by faster-replicating parasitic mutants.},
	language = {en},
	number = {6317},
	urldate = {2018-02-01TZ},
	journal = {Science},
	author = {Matsumura, Shigeyoshi and Kun, Ádám and Ryckelynck, Michael and Coldren, Faith and Szilágyi, András and Jossinet, Fabrice and Rick, Christian and Nghe, Philippe and Szathmáry, Eörs and Griffiths, Andrew D.},
	month = dec,
	year = {2016},
	pmid = {27940874},
	note = {00014 },
	pages = {1293--1296}
}
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