Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice. Matsuoka, T., Kurohane, K., Suzuki, W., Ogawa, E., Kobayashi, K., & Imai, Y. Biological & Pharmaceutical Bulletin, 39(2):272--277, 2016. 00000
doi  abstract   bibtex   
Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a butyl alcohol ester of di-carboxylic acid that represents a part of the DBP structure, while di-n-butyl fumarate (DBF) is a trans isomer of DBM. We examined whether DBM or DBF exhibits an adjuvant effect like DBP does. When BALB/c mice were epicutaneously sensitized with FITC in the presence of DBM or DBF, the FITC-specific CHS response was enhanced, as we have observed for DBP. As to underlying mechanisms, DBM and DBF facilitated the trafficking of FITC-presenting CD11c(+) dendritic cells (DCs) from skin to draining lymph nodes and increased the cytokine production by draining lymph nodes. In conclusion, DBM and DBF may have an effect that aggravates contact dermatitis through a skin sensitization process.
@article{matsuoka_dibutyl_2016,
	title = {Dibutyl {Maleate} and {Dibutyl} {Fumarate} {Enhance} {Contact} {Sensitization} to {Fluorescein} {Isothiocyanate} in {Mice}},
	volume = {39},
	issn = {1347-5215},
	doi = {10.1248/bpb.b15-00683},
	abstract = {Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a butyl alcohol ester of di-carboxylic acid that represents a part of the DBP structure, while di-n-butyl fumarate (DBF) is a trans isomer of DBM. We examined whether DBM or DBF exhibits an adjuvant effect like DBP does. When BALB/c mice were epicutaneously sensitized with FITC in the presence of DBM or DBF, the FITC-specific CHS response was enhanced, as we have observed for DBP. As to underlying mechanisms, DBM and DBF facilitated the trafficking of FITC-presenting CD11c(+) dendritic cells (DCs) from skin to draining lymph nodes and increased the cytokine production by draining lymph nodes. In conclusion, DBM and DBF may have an effect that aggravates contact dermatitis through a skin sensitization process.},
	language = {eng},
	number = {2},
	journal = {Biological \& Pharmaceutical Bulletin},
	author = {Matsuoka, Takeshi and Kurohane, Kohta and Suzuki, Wakana and Ogawa, Erina and Kobayashi, Kamiyu and Imai, Yasuyuki},
	year = {2016},
	pmid = {26632200},
	note = {00000 },
	keywords = {Animals, Cytokines, Dermatitis, Contact, Drug Hypersensitivity, Fluorescein-5-isothiocyanate, Fumarates, Gene Expression Regulation, Lymph Nodes, Maleates, Mice, Mice, Inbred BALB C, Molecular Structure},
	pages = {272--277}
}
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