@misc{ma_x.-y._clinical_2016,
	title = {Clinical efficacy of different doses of gamma globulin combined with glucocorticoid in treatment of moderate/severe acute {Guillain}-{Barre} syndrome in children: {A} comparative analysis},
	url = {http://www.cjcp.org/EN/article/downloadArticleFile.do?attachType=PDF&id=14078},
	abstract = {Objective: To investigate the clinical efficacy and safety of intravenous injection of low-dose versus high-dose gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with moderate/severe acute Guillain-Barre syndrome (GBS). Methods: A total of 100 children with moderate/severe acute GBS were randomly assigned to low-dose group (n=48) and high-dose group (n=52). The children in the low-dose and high-dose groups were treated with 0.2 g/(kg . d) and 0.4 g/(kg . d) gamma globulin respectively combined with methylprednisolone. The two groups were compared in terms of the time to improvements of symptoms after treatment, serum levels of inflammatory factors, proportion of children undergoing invasive ventilation, treatment response rate, and adverse events. Results: After 5 days of treatment, the low- and high-dose groups had significant reductions in serum levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein, and there were no significant differences in the reductions of these markers between the two groups. There were no significant differences between the two groups in the time to recovery of respiratory muscle paralysis, time to an improvement in muscle strength of one grade, time to recovery of sensory disturbance, and length of hospital stay. There was no significant difference in the treatment response rate between the low- and high-dose groups (90\% vs 92\%). There were also no significant differences in the incidence rates of pyrexia, headache, nausea, and palpitation between the two groups. Conclusions: Low-dose versus high-dose gamma globulin combined with methylprednisolone pulse therapy have comparable clinical efficacy and safety in the treatment of children with moderate/severe acute GBS.},
	journal = {Chinese Journal of Contemporary Pediatrics},
	author = {{Ma X.-Y.} and {Li Z.} and {Wang X.-J.} and {Ye J.-J.} and {Ma Y.-P.} and {Li Y.}},
	year = {2016},
	keywords = {*immunoglobulin, *methylprednisolone, *syndrome, C reactive protein, Child, Pharmacokinetics, adverse drug reaction, artificial ventilation, clinical trial, controlled clinical trial, controlled study, diaphragm paralysis, drug megadose, drug therapy, endogenous compound, fever, gene expression, headache, heart palpitation, hospitalization, human, human tissue, incidence, interleukin 6, low drug dose, major clinical study, muscle strength, nausea, randomized controlled trial, remission, safety, sensory dysfunction, side effect, symptom, treatment response, tumor necrosis factor}
}

{"_id":"ddPPQCHceb977Rmje","bibbaseid":"maxy-liz-wangxj-yejj-mayp-liy-clinicalefficacyofdifferentdosesofgammaglobulincombinedwithglucocorticoidintreatmentofmoderatesevereacuteguillainbarresyndromeinchildrenacomparativeanalysis-2016","downloads":0,"creationDate":"2017-05-12T20:20:57.565Z","title":"Clinical efficacy of different doses of gamma globulin combined with glucocorticoid in treatment of moderate/severe acute Guillain-Barre syndrome in children: A comparative analysis","author_short":["Ma X.-Y.","Li Z.","Wang X.-J.","Ye J.-J.","Ma Y.-P.","Li Y."],"year":2016,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Clinical efficacy of different doses of gamma globulin combined with glucocorticoid in treatment of moderate/severe acute Guillain-Barre syndrome in children: A comparative analysis","url":"http://www.cjcp.org/EN/article/downloadArticleFile.do?attachType=PDF&id=14078","abstract":"Objective: To investigate the clinical efficacy and safety of intravenous injection of low-dose versus high-dose gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with moderate/severe acute Guillain-Barre syndrome (GBS). Methods: A total of 100 children with moderate/severe acute GBS were randomly assigned to low-dose group (n=48) and high-dose group (n=52). The children in the low-dose and high-dose groups were treated with 0.2 g/(kg . d) and 0.4 g/(kg . d) gamma globulin respectively combined with methylprednisolone. The two groups were compared in terms of the time to improvements of symptoms after treatment, serum levels of inflammatory factors, proportion of children undergoing invasive ventilation, treatment response rate, and adverse events. Results: After 5 days of treatment, the low- and high-dose groups had significant reductions in serum levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein, and there were no significant differences in the reductions of these markers between the two groups. There were no significant differences between the two groups in the time to recovery of respiratory muscle paralysis, time to an improvement in muscle strength of one grade, time to recovery of sensory disturbance, and length of hospital stay. There was no significant difference in the treatment response rate between the low- and high-dose groups (90% vs 92%). There were also no significant differences in the incidence rates of pyrexia, headache, nausea, and palpitation between the two groups. Conclusions: Low-dose versus high-dose gamma globulin combined with methylprednisolone pulse therapy have comparable clinical efficacy and safety in the treatment of children with moderate/severe acute GBS.","journal":"Chinese Journal of Contemporary Pediatrics","author":[{"firstnames":[],"propositions":[],"lastnames":["Ma X.-Y."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Li Z."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Wang X.-J."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Ye J.-J."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Ma Y.-P."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Li Y."],"suffixes":[]}],"year":"2016","keywords":"*immunoglobulin, *methylprednisolone, *syndrome, C reactive protein, Child, Pharmacokinetics, adverse drug reaction, artificial ventilation, clinical trial, controlled clinical trial, controlled study, diaphragm paralysis, drug megadose, drug therapy, endogenous compound, fever, gene expression, headache, heart palpitation, hospitalization, human, human tissue, incidence, interleukin 6, low drug dose, major clinical study, muscle strength, nausea, randomized controlled trial, remission, safety, sensory dysfunction, side effect, symptom, treatment response, tumor necrosis factor","bibtex":"@misc{ma_x.-y._clinical_2016,\n\ttitle = {Clinical efficacy of different doses of gamma globulin combined with glucocorticoid in treatment of moderate/severe acute {Guillain}-{Barre} syndrome in children: {A} comparative analysis},\n\turl = {http://www.cjcp.org/EN/article/downloadArticleFile.do?attachType=PDF&id=14078},\n\tabstract = {Objective: To investigate the clinical efficacy and safety of intravenous injection of low-dose versus high-dose gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with moderate/severe acute Guillain-Barre syndrome (GBS). Methods: A total of 100 children with moderate/severe acute GBS were randomly assigned to low-dose group (n=48) and high-dose group (n=52). The children in the low-dose and high-dose groups were treated with 0.2 g/(kg . d) and 0.4 g/(kg . d) gamma globulin respectively combined with methylprednisolone. The two groups were compared in terms of the time to improvements of symptoms after treatment, serum levels of inflammatory factors, proportion of children undergoing invasive ventilation, treatment response rate, and adverse events. Results: After 5 days of treatment, the low- and high-dose groups had significant reductions in serum levels of tumor necrosis factor-alpha, interleukin-6, and C-reactive protein, and there were no significant differences in the reductions of these markers between the two groups. There were no significant differences between the two groups in the time to recovery of respiratory muscle paralysis, time to an improvement in muscle strength of one grade, time to recovery of sensory disturbance, and length of hospital stay. There was no significant difference in the treatment response rate between the low- and high-dose groups (90\\% vs 92\\%). There were also no significant differences in the incidence rates of pyrexia, headache, nausea, and palpitation between the two groups. Conclusions: Low-dose versus high-dose gamma globulin combined with methylprednisolone pulse therapy have comparable clinical efficacy and safety in the treatment of children with moderate/severe acute GBS.},\n\tjournal = {Chinese Journal of Contemporary Pediatrics},\n\tauthor = {{Ma X.-Y.} and {Li Z.} and {Wang X.-J.} and {Ye J.-J.} and {Ma Y.-P.} and {Li Y.}},\n\tyear = {2016},\n\tkeywords = {*immunoglobulin, *methylprednisolone, *syndrome, C reactive protein, Child, Pharmacokinetics, adverse drug reaction, artificial ventilation, clinical trial, controlled clinical trial, controlled study, diaphragm paralysis, drug megadose, drug therapy, endogenous compound, fever, gene expression, headache, heart palpitation, hospitalization, human, human tissue, incidence, interleukin 6, low drug dose, major clinical study, muscle strength, nausea, randomized controlled trial, remission, safety, sensory dysfunction, side effect, symptom, treatment response, tumor necrosis factor}\n}\n\n","author_short":["Ma X.-Y.","Li Z.","Wang X.-J.","Ye J.-J.","Ma Y.-P.","Li Y."],"key":"ma_x.-y._clinical_2016","id":"ma_x.-y._clinical_2016","bibbaseid":"maxy-liz-wangxj-yejj-mayp-liy-clinicalefficacyofdifferentdosesofgammaglobulincombinedwithglucocorticoidintreatmentofmoderatesevereacuteguillainbarresyndromeinchildrenacomparativeanalysis-2016","role":"author","urls":{"Paper":"http://www.cjcp.org/EN/article/downloadArticleFile.do?attachType=PDF&id=14078"},"keyword":["*immunoglobulin","*methylprednisolone","*syndrome","C reactive protein","Child","Pharmacokinetics","adverse drug reaction","artificial ventilation","clinical trial","controlled clinical trial","controlled study","diaphragm paralysis","drug megadose","drug therapy","endogenous compound","fever","gene expression","headache","heart palpitation","hospitalization","human","human tissue","incidence","interleukin 6","low drug dose","major clinical study","muscle strength","nausea","randomized controlled trial","remission","safety","sensory dysfunction","side effect","symptom","treatment response","tumor necrosis factor"],"downloads":0,"html":""},"search_terms":["clinical","efficacy","different","doses","gamma","globulin","combined","glucocorticoid","treatment","moderate","severe","acute","guillain","barre","syndrome","children","comparative","analysis","ma x.-y.","li z.","wang x.-j.","ye j.-j.","ma y.-p.","li y."],"keywords":["*immunoglobulin","*methylprednisolone","*syndrome","c reactive protein","child","pharmacokinetics","adverse drug reaction","artificial ventilation","clinical trial","controlled clinical trial","controlled study","diaphragm paralysis","drug megadose","drug therapy","endogenous compound","fever","gene expression","headache","heart palpitation","hospitalization","human","human tissue","incidence","interleukin 6","low drug dose","major clinical study","muscle strength","nausea","randomized controlled trial","remission","safety","sensory dysfunction","side effect","symptom","treatment response","tumor necrosis factor"],"authorIDs":[],"dataSources":["9LqPNaySNpNxYBFzj"]}