Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology. McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., Ketchesin, K. D., Landgraf, D., Lee, H., Marie-Claire, C., Nusslock, R., Porcu, A., Porter, R., Ritter, P., Scott, J., Smith, D., Swartz, H. A., & Murray, G. Bipolar Disorders, 24(3):232–263, 2022. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/bdi.13165![Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. Method Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. Results Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. Conclusions Future research in circadian rhythms and its role in BD is warranted. Well-powered studies that carefully define associations between BD-related and chronobiologically-related constructs, and integrate across levels of analysis will be most illuminating.
@article{mccarthy2022,
title = {Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: {A} critical multi-disciplinary literature review and agenda for future research from the {ISBD} task force on chronobiology},
volume = {24},
issn = {1399-5618},
shorttitle = {Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder},
url = {http://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.13165},
doi = {10.1111/bdi.13165},
abstract = {Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. Method Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. Results Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. Conclusions Future research in circadian rhythms and its role in BD is warranted. Well-powered studies that carefully define associations between BD-related and chronobiologically-related constructs, and integrate across levels of analysis will be most illuminating.},
language = {en},
number = {3},
urldate = {2022-07-29},
journal = {Bipolar Disorders},
author = {McCarthy, Michael J. and Gottlieb, John F. and Gonzalez, Robert and McClung, Colleen A. and Alloy, Lauren B. and Cain, Sean and Dulcis, Davide and Etain, Bruno and Frey, Benicio N. and Garbazza, Corrado and Ketchesin, Kyle D. and Landgraf, Dominic and Lee, Heon-Jeong and Marie-Claire, Cynthia and Nusslock, Robin and Porcu, Alessandra and Porter, Richard and Ritter, Philipp and Scott, Jan and Smith, Daniel and Swartz, Holly A. and Murray, Greg},
year = {2022},
note = {\_eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/bdi.13165},
keywords = {clock gene, lithium, actigraphy, animal models, biomarker, chronobiology, circadian, levels of analysis, light, sleep},
pages = {232--263},
annote = {\_eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/bdi.13165},
file = {Full Text PDF:/Users/lcneuro/Zotero/storage/P8BPLBX9/McCarthy et al. - 2022 - Neurobiological and behavioral mechanisms of circa.pdf:application/pdf;Snapshot:/Users/lcneuro/Zotero/storage/DY6ERQBK/bdi.html:text/html},
}
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A.","Murray, G."],"bibdata":{"bibtype":"article","type":"article","title":"Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology","volume":"24","issn":"1399-5618","shorttitle":"Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder","url":"http://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.13165","doi":"10.1111/bdi.13165","abstract":"Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, circadian rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD. Method Drawing upon expertise in animal models, biomarkers, physiology, and behavior, CTF analyzed the relevant cross-disciplinary literature to precisely frame the discussion around circadian rhythm disruption in BD, highlight key findings, and for the first time integrate findings across levels of analysis to develop an internally consistent, coherent theoretical framework. Results Evidence from multiple sources implicates the circadian system in mood regulation, with corresponding associations with BD diagnoses and mood-related traits reported across genetic, cellular, physiological, and behavioral domains. However, circadian disruption does not appear to be specific to BD and is present across a variety of high-risk, prodromal, and syndromic psychiatric disorders. Substantial variability and ambiguity among the definitions, concepts and assumptions underlying the research have limited replication and the emergence of consensus findings. Conclusions Future research in circadian rhythms and its role in BD is warranted. 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