Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. McGregor, D B, Brown, A G, Howgate, S, McBride, D, Riach, C, & Caspary, W J Environmental and molecular mutagenesis, 17(3):196–219, January, 1991. ![Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Twenty-seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143-160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 micrograms/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o-chloroaniline, chlorodibromomethane, cytembena, 1,2-dibromo-4-(1,2-dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1-phenyl-3-methyl-5-pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4-toluene diisocyanate, and 2,6-toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemical not identified as mutagens were N-4-acetylaminofluorene, chlorpheniramine maleate, chloropropamide, 1,4-dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2-ethylhexyl)alcohol
@article{mcgregor_responses_1991,
title = {Responses of the {L5178Y} mouse {Lymphoma} cell forward mutation assay. {V}: 27 coded chemicals.},
volume = {17},
issn = {0893-6692},
url = {http://www.ncbi.nlm.nih.gov/pubmed/1902415},
abstract = {Twenty-seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143-160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 micrograms/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o-chloroaniline, chlorodibromomethane, cytembena, 1,2-dibromo-4-(1,2-dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1-phenyl-3-methyl-5-pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4-toluene diisocyanate, and 2,6-toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemical not identified as mutagens were N-4-acetylaminofluorene, chlorpheniramine maleate, chloropropamide, 1,4-dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2-ethylhexyl)alcohol},
number = {3},
journal = {Environmental and molecular mutagenesis},
author = {McGregor, D B and Brown, A G and Howgate, S and McBride, D and Riach, C and Caspary, W J},
month = jan,
year = {1991},
pmid = {1902415},
keywords = {Animals, Cultured, Data Interpretation, Evaluation Studies as Topic, Flame retardants, Inbred F344, Male, Mice, Molecular Structure, Mutagenicity Tests, Mutagens, Mutagens: toxicity, Quality Control, Rats, Statistical, Thymidine Kinase, Thymidine Kinase: genetics, Trifluridine, Tumor Cells},
pages = {196--219},
}
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The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o-chloroaniline, chlorodibromomethane, cytembena, 1,2-dibromo-4-(1,2-dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1-phenyl-3-methyl-5-pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4-toluene diisocyanate, and 2,6-toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemical not identified as mutagens were N-4-acetylaminofluorene, chlorpheniramine maleate, chloropropamide, 1,4-dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2-ethylhexyl)alcohol","number":"3","journal":"Environmental and molecular mutagenesis","author":[{"propositions":[],"lastnames":["McGregor"],"firstnames":["D","B"],"suffixes":[]},{"propositions":[],"lastnames":["Brown"],"firstnames":["A","G"],"suffixes":[]},{"propositions":[],"lastnames":["Howgate"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["McBride"],"firstnames":["D"],"suffixes":[]},{"propositions":[],"lastnames":["Riach"],"firstnames":["C"],"suffixes":[]},{"propositions":[],"lastnames":["Caspary"],"firstnames":["W","J"],"suffixes":[]}],"month":"January","year":"1991","pmid":"1902415","keywords":"Animals, Cultured, Data Interpretation, Evaluation Studies as Topic, Flame retardants, Inbred F344, Male, Mice, Molecular Structure, Mutagenicity Tests, Mutagens, Mutagens: toxicity, Quality Control, Rats, Statistical, Thymidine Kinase, Thymidine Kinase: genetics, Trifluridine, Tumor Cells","pages":"196–219","bibtex":"@article{mcgregor_responses_1991,\n\ttitle = {Responses of the {L5178Y} mouse {Lymphoma} cell forward mutation assay. {V}: 27 coded chemicals.},\n\tvolume = {17},\n\tissn = {0893-6692},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/1902415},\n\tabstract = {Twenty-seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143-160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 micrograms/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o-chloroaniline, chlorodibromomethane, cytembena, 1,2-dibromo-4-(1,2-dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1-phenyl-3-methyl-5-pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4-toluene diisocyanate, and 2,6-toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemical not identified as mutagens were N-4-acetylaminofluorene, chlorpheniramine maleate, chloropropamide, 1,4-dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2-ethylhexyl)alcohol},\n\tnumber = {3},\n\tjournal = {Environmental and molecular mutagenesis},\n\tauthor = {McGregor, D B and Brown, A G and Howgate, S and McBride, D and Riach, C and Caspary, W J},\n\tmonth = jan,\n\tyear = {1991},\n\tpmid = {1902415},\n\tkeywords = {Animals, Cultured, Data Interpretation, Evaluation Studies as Topic, Flame retardants, Inbred F344, Male, Mice, Molecular Structure, Mutagenicity Tests, Mutagens, Mutagens: toxicity, Quality Control, Rats, Statistical, Thymidine Kinase, Thymidine Kinase: genetics, Trifluridine, Tumor Cells},\n\tpages = {196--219},\n}\n\n","author_short":["McGregor, D B","Brown, A G","Howgate, S","McBride, D","Riach, C","Caspary, W J"],"key":"mcgregor_responses_1991","id":"mcgregor_responses_1991","bibbaseid":"mcgregor-brown-howgate-mcbride-riach-caspary-responsesofthel5178ymouselymphomacellforwardmutationassayv27codedchemicals-1991","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/1902415"},"keyword":["Animals","Cultured","Data Interpretation","Evaluation Studies as Topic","Flame retardants","Inbred F344","Male","Mice","Molecular Structure","Mutagenicity Tests","Mutagens","Mutagens: toxicity","Quality Control","Rats","Statistical","Thymidine Kinase","Thymidine Kinase: genetics","Trifluridine","Tumor Cells"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/mdedeo","dataSources":["SSfxPwd7XbkRtnZ9f"],"keywords":["animals","cultured","data interpretation","evaluation studies as topic","flame retardants","inbred f344","male","mice","molecular structure","mutagenicity tests","mutagens","mutagens: toxicity","quality control","rats","statistical","thymidine kinase","thymidine kinase: genetics","trifluridine","tumor cells"],"search_terms":["responses","l5178y","mouse","lymphoma","cell","forward","mutation","assay","coded","chemicals","mcgregor","brown","howgate","mcbride","riach","caspary"],"title":"Responses of the L5178Y mouse Lymphoma cell forward mutation assay. 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