A Multicenter, randomized, controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary bypass. McGuinnes, S., P., Parke, R., L., Drummond, K., Willox, T., & Bailey, M. Anesthesiology, 125(3):465-73, 2016.
A Multicenter, randomized, controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary bypass [pdf]Paper  abstract   bibtex   
Background: Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. Cardiac surgery–associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. Pathophysiology of CSA-MOD involves numerous injurious pathways linked to the use of CPB including oxidative stress and formation of reactive iron species. During cardiac surgery with CPB, arterial return blood is oxygenated to supranormal levels. This study aimed to determine whether the avoidance of arterial hyperoxemia decreased oxidative stress and reduced the severity of the multiorgan dysfunc- tion in patients undergoing cardiac surgery utilizing CPB. Methods: The study was a multicenter, open-label, parallel-group, randomized controlled study of the avoidance of arterial hyperoxemia versus usual care in patients undergoing cardiac surgery involving CPB. Primary outcome was the incidence and severity of AKI. Secondary outcomes included serum biomarkers for CSA-MOD, duration of mechanical ventilation, and length of intensive care and hospital stay. Results: A total of 298 patients were randomized and analyzed at two hospitals in New Zealand and Australia. Mean PaO2 was significantly different between groups during CPB. There was no difference in the development of AKI (intervention arm 72.0% vs. usual care 66.2%; difference, −5.8% [95% CI, −16.1 to 4.7%]; P = 0.28), other markers of organ damage, or intensive care unit and hospital length of stay. Conclusions: Avoiding modest hyperoxemia during CPB failed to demonstrate any difference in AKI, markers of organ dam- age, or length of stay.
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 title = {A Multicenter, randomized, controlled Phase IIb Trial of Avoidance of Hyperoxemia during Cardiopulmonary bypass},
 type = {article},
 year = {2016},
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 keywords = {Anticoagulation,blood pump,cardiac surgery,cardiopulmonary bypass,oxygenator,reservoir,separation from CPB},
 pages = {465-73},
 volume = {125},
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 abstract = {Background: Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. Cardiac surgery–associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. Pathophysiology of CSA-MOD involves numerous injurious pathways linked to the use of CPB including oxidative stress and formation of reactive iron species. During cardiac surgery with CPB, arterial return blood is oxygenated to supranormal levels. This study aimed to determine whether the avoidance of arterial hyperoxemia decreased oxidative stress and reduced the severity of the multiorgan dysfunc- tion in patients undergoing cardiac surgery utilizing CPB. Methods: The study was a multicenter, open-label, parallel-group, randomized controlled study of the avoidance of arterial hyperoxemia versus usual care in patients undergoing cardiac surgery involving CPB. Primary outcome was the incidence and severity of AKI. Secondary outcomes included serum biomarkers for CSA-MOD, duration of mechanical ventilation, and length of intensive care and hospital stay. Results: A total of 298 patients were randomized and analyzed at two hospitals in New Zealand and Australia. Mean PaO2 was significantly different between groups during CPB. There was no difference in the development of AKI (intervention arm 72.0% vs. usual care 66.2%; difference, −5.8% [95% CI, −16.1 to 4.7%]; P = 0.28), other markers of organ damage, or intensive care unit and hospital length of stay. Conclusions: Avoiding modest hyperoxemia during CPB failed to demonstrate any difference in AKI, markers of organ dam- age, or length of stay.},
 bibtype = {article},
 author = {McGuinnes, Shay P. and Parke, Rachael L. and Drummond, Kate and Willox, Tim and Bailey, Michael},
 journal = {Anesthesiology},
 number = {3}
}
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