@article{mcmahon_novel_2002,
	title = {Novel factor-based symptom scores in treatment resistant schizophrenia: {Implications} for clinical trials},
	volume = {26},
	issn = {0893-133X},
	url = {https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,uid&db=psyh&AN=2002-12611-013&site=ehost-live},
	doi = {10.1016/S0893-133X(01)00387-6},
	abstract = {Studied the factor structure of symptoms in patients with treatment resistant schizophrenia and whether it is altered by treatment. We analyzed ratings on the Brief Psychiatric Rating Scale (BPRS) from 2 independent groups of patients with treatment resistant schizophrenia. With confirmatory factor analysis of pre-clozapine BPRS scores in 1,074 patients (aged 14.4-81.3 yrs) in an administrative database, the Clozapine Authorization and Monitoring Program (CAMP), we assessed the fit of published factor models an developed a better-fitting model. Model fit was validated in an independent group of 197 research unit participants (aged 18-62 yrs). Stability of model fit 6 mo post-clozapine was assessed in 834 CAMP patients. A new 4-factor model (negative symptoms, reality distortion, disorganization, and anxiety depression) had better fit in both data sets than two commonly used factor models, and also fit better post-clozapine. We recommend these four factor scores as clinic trial outcomes in patients with treatment resistant schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
	number = {4},
	journal = {Neuropsychopharmacology},
	author = {McMahon, Robert P. and Kelly, Deanna L. and Kreyenbuhl, Julie and Kirkpatrick, Brian and Love, Raymond C. and Conley, Robert R.},
	month = apr,
	year = {2002},
	note = {Publisher: Nature Publishing Group},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antipsychotic Agents, Clinical Trials as Topic, Clozapine, Databases, Factual, Drug Resistance, Drug Therapy, Factor Analysis, Factor Analysis, Statistical, Factor Structure, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Maryland, Middle Aged, Psychiatric Status Rating Scales, Research Design, Schizophrenia, Schizophrenic Psychology, Symptoms, Treatment Resistant Disorders, factor structure of symptoms, pre \& post clozapine, treatment resistant schizophrenia},
	pages = {537--545},
}

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With confirmatory factor analysis of pre-clozapine BPRS scores in 1,074 patients (aged 14.4-81.3 yrs) in an administrative database, the Clozapine Authorization and Monitoring Program (CAMP), we assessed the fit of published factor models an developed a better-fitting model. Model fit was validated in an independent group of 197 research unit participants (aged 18-62 yrs). Stability of model fit 6 mo post-clozapine was assessed in 834 CAMP patients. A new 4-factor model (negative symptoms, reality distortion, disorganization, and anxiety depression) had better fit in both data sets than two commonly used factor models, and also fit better post-clozapine. We recommend these four factor scores as clinic trial outcomes in patients with treatment resistant schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)","number":"4","journal":"Neuropsychopharmacology","author":[{"propositions":[],"lastnames":["McMahon"],"firstnames":["Robert","P."],"suffixes":[]},{"propositions":[],"lastnames":["Kelly"],"firstnames":["Deanna","L."],"suffixes":[]},{"propositions":[],"lastnames":["Kreyenbuhl"],"firstnames":["Julie"],"suffixes":[]},{"propositions":[],"lastnames":["Kirkpatrick"],"firstnames":["Brian"],"suffixes":[]},{"propositions":[],"lastnames":["Love"],"firstnames":["Raymond","C."],"suffixes":[]},{"propositions":[],"lastnames":["Conley"],"firstnames":["Robert","R."],"suffixes":[]}],"month":"April","year":"2002","note":"Publisher: Nature Publishing Group","keywords":"Adolescent, Adult, Aged, Aged, 80 and over, Antipsychotic Agents, Clinical Trials as Topic, Clozapine, Databases, Factual, Drug Resistance, Drug Therapy, Factor Analysis, Factor Analysis, Statistical, Factor Structure, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Maryland, Middle Aged, Psychiatric Status Rating Scales, Research Design, Schizophrenia, Schizophrenic Psychology, Symptoms, Treatment Resistant Disorders, factor structure of symptoms, pre & post clozapine, treatment resistant schizophrenia","pages":"537–545","bibtex":"@article{mcmahon_novel_2002,\n\ttitle = {Novel factor-based symptom scores in treatment resistant schizophrenia: {Implications} for clinical trials},\n\tvolume = {26},\n\tissn = {0893-133X},\n\turl = {https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,uid&db=psyh&AN=2002-12611-013&site=ehost-live},\n\tdoi = {10.1016/S0893-133X(01)00387-6},\n\tabstract = {Studied the factor structure of symptoms in patients with treatment resistant schizophrenia and whether it is altered by treatment. 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