Novel factor-based symptom scores in treatment resistant schizophrenia: Implications for clinical trials. McMahon, R. P., Kelly, D. L., Kreyenbuhl, J., Kirkpatrick, B., Love, R. C., & Conley, R. R. Neuropsychopharmacology, 26(4):537–545, April, 2002. Publisher: Nature Publishing Group
Novel factor-based symptom scores in treatment resistant schizophrenia: Implications for clinical trials [link]Paper  doi  abstract   bibtex   
Studied the factor structure of symptoms in patients with treatment resistant schizophrenia and whether it is altered by treatment. We analyzed ratings on the Brief Psychiatric Rating Scale (BPRS) from 2 independent groups of patients with treatment resistant schizophrenia. With confirmatory factor analysis of pre-clozapine BPRS scores in 1,074 patients (aged 14.4-81.3 yrs) in an administrative database, the Clozapine Authorization and Monitoring Program (CAMP), we assessed the fit of published factor models an developed a better-fitting model. Model fit was validated in an independent group of 197 research unit participants (aged 18-62 yrs). Stability of model fit 6 mo post-clozapine was assessed in 834 CAMP patients. A new 4-factor model (negative symptoms, reality distortion, disorganization, and anxiety depression) had better fit in both data sets than two commonly used factor models, and also fit better post-clozapine. We recommend these four factor scores as clinic trial outcomes in patients with treatment resistant schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
@article{mcmahon_novel_2002,
	title = {Novel factor-based symptom scores in treatment resistant schizophrenia: {Implications} for clinical trials},
	volume = {26},
	issn = {0893-133X},
	url = {https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,uid&db=psyh&AN=2002-12611-013&site=ehost-live},
	doi = {10.1016/S0893-133X(01)00387-6},
	abstract = {Studied the factor structure of symptoms in patients with treatment resistant schizophrenia and whether it is altered by treatment. We analyzed ratings on the Brief Psychiatric Rating Scale (BPRS) from 2 independent groups of patients with treatment resistant schizophrenia. With confirmatory factor analysis of pre-clozapine BPRS scores in 1,074 patients (aged 14.4-81.3 yrs) in an administrative database, the Clozapine Authorization and Monitoring Program (CAMP), we assessed the fit of published factor models an developed a better-fitting model. Model fit was validated in an independent group of 197 research unit participants (aged 18-62 yrs). Stability of model fit 6 mo post-clozapine was assessed in 834 CAMP patients. A new 4-factor model (negative symptoms, reality distortion, disorganization, and anxiety depression) had better fit in both data sets than two commonly used factor models, and also fit better post-clozapine. We recommend these four factor scores as clinic trial outcomes in patients with treatment resistant schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)},
	number = {4},
	journal = {Neuropsychopharmacology},
	author = {McMahon, Robert P. and Kelly, Deanna L. and Kreyenbuhl, Julie and Kirkpatrick, Brian and Love, Raymond C. and Conley, Robert R.},
	month = apr,
	year = {2002},
	note = {Publisher: Nature Publishing Group},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antipsychotic Agents, Clinical Trials as Topic, Clozapine, Databases, Factual, Drug Resistance, Drug Therapy, Factor Analysis, Factor Analysis, Statistical, Factor Structure, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Maryland, Middle Aged, Psychiatric Status Rating Scales, Research Design, Schizophrenia, Schizophrenic Psychology, Symptoms, Treatment Resistant Disorders, factor structure of symptoms, pre \& post clozapine, treatment resistant schizophrenia},
	pages = {537--545},
}

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