Association between body mass index and subcortical brain volumes in bipolar disorders–\ENIGMA\ study in 2735 individuals. McWhinney, S. R, Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J, Cannon, D. M, Dannlowski, U., Díaz-Zuluaga, A. M, Elvsåshagen, T., Eyler, L. T, Fullerton, J. M, Goikolea, J. M, Goltermann, J., Grotegerd, D., Haarman, B. C M, Hahn, T., Howells, F. M, Ingvar, M., Kircher, T. T J, Krug, A., Kuplicki, R. T, Landén, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F, Martyn, F. M, Mazza, E., McDonald, C., McPhilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M T, Mitchell, P. B, Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A, Overs, B. J, Pfarr, J., Pineda-Zapata, J. A, Pomarol-Clotet, E., Raduà, J., Repple, J., Richter, M., Ringwald, K. G, Roberts, G., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R, Sim, K., Stein, D. J, Stein, F., Temmingh, H. S, Thiel, K., Van Haren, N. E M, Gestel, H. V., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N, Ching, C. R K, Andreassen, O., Thompson, P. M, Hajek, T., & for the ENIGMA Bipolar Disorders Working Group Molecular Psychiatry, 26(11):6806–6819, nov, 2021. ![Association between body mass index and subcortical brain volumes in bipolar disorders–\ENIGMA\ study in 2735 individuals [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Abstract Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI ( Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
@article{mcwhinney_association_2021,
abstract = {Abstract
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41{\%} of the association between BD and ventricular volume was mediated by BMI (
Z
= 2.73,
p
= 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.},
author = {McWhinney, Sean R and Ab{\'{e}}, Christoph and Alda, Martin and Benedetti, Francesco and B{\o}en, Erlend and {Del Mar Bonnin}, Caterina and Borgers, Tiana and Brosch, Katharina and Canales-Rodr{\'{i}}guez, Erick J and Cannon, Dara M and Dannlowski, Udo and D{\'{i}}az-Zuluaga, Ana M and Elvs{\aa}shagen, Torbj{\o}rn and Eyler, Lisa T and Fullerton, Janice M and Goikolea, Jose M and Goltermann, Janik and Grotegerd, Dominik and Haarman, Bartholomeus C M and Hahn, Tim and Howells, Fleur M and Ingvar, Martin and Kircher, Tilo T J and Krug, Axel and Kuplicki, Rayus T and Land{\'{e}}n, Mikael and Lemke, Hannah and Liberg, Benny and Lopez-Jaramillo, Carlos and Malt, Ulrik F and Martyn, Fiona M and Mazza, Elena and McDonald, Colm and McPhilemy, Genevieve and Meier, Sandra and Meinert, Susanne and Meller, Tina and Melloni, Elisa M T and Mitchell, Philip B and Nabulsi, Leila and Nenadic, Igor and Opel, Nils and Ophoff, Roel A and Overs, Bronwyn J and Pfarr, Julia-Katharina and Pineda-Zapata, Julian A and Pomarol-Clotet, Edith and Radu{\`{a}}, Joaquim and Repple, Jonathan and Richter, Maike and Ringwald, Kai G and Roberts, Gloria and Salvador, Raymond and Savitz, Jonathan and Schmitt, Simon and Schofield, Peter R and Sim, Kang and Stein, Dan J and Stein, Frederike and Temmingh, Henk S and Thiel, Katharina and {Van Haren}, Neeltje E M and Gestel, Holly Van and Vargas, Cristian and Vieta, Eduard and Vreeker, Annabel and Waltemate, Lena and Yatham, Lakshmi N and Ching, Christopher R K and Andreassen, Ole and Thompson, Paul M and Hajek, Tomas and {for the ENIGMA Bipolar Disorders Working Group}},
doi = {10.1038/s41380-021-01098-x},
file = {:Users/jacquelinebracher/Zotero/storage/RB6S8WYI/McWhinney et al. - 2021 - Association between body mass index and subcortica.pdf:pdf},
issn = {1359-4184, 1476-5578},
journal = {Molecular Psychiatry},
month = {nov},
number = {11},
pages = {6806--6819},
title = {{Association between body mass index and subcortical brain volumes in bipolar disorders–{\{}ENIGMA{\}} study in 2735 individuals}},
url = {https://www.nature.com/articles/s41380-021-01098-x},
volume = {26},
year = {2021}
}
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Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41{\\%} of the association between BD and ventricular volume was mediated by BMI (\nZ\n= 2.73,\np\n= 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. 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