1-liner: This correspondence letter published in The Lancet recommends identifying and treating hyperinflammation, such as secondary HLH, in severe COVID-19.
Summary
Article type – correspondence letter
Main takeaways:
@article{mehta_covid-19_2020, title = {{COVID}-19: consider cytokine storm syndromes and immunosuppression}, volume = {395}, issn = {0140-6736, 1474-547X}, shorttitle = {{COVID}-19}, url = {https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/abstract}, doi = {10.1016/S0140-6736(20)30628-0}, abstract = {<p><u>1-liner</u>: This correspondence letter published in The Lancet recommends identifying and treating hyperinflammation, such as secondary HLH, in severe COVID-19.</p> <p>\ </p> <p><u>Summary</u></p> <p>Article type \– correspondence letter</p> <p>Main takeaways:</p> <ul> <li>Severe COVID-19 disease appears to be associated with a cytokine profile resembling secondary HLH, \“characterized by increased interleukin (IL)-2, IL-7, granulocyte-colony stimulating factor, interferon-\γ inducible protein 10, monocyte chemo-attractant protein 1, macrophage inflammatory protein 1-\α, and tumour necrosis factor-\α\”</li> <li> Elevated ferritin and IL-6, which may suggest \“hyperinflammation,\” were found to be predictors of fatality from a retrospective study of 150 COVID-19 cases in Wuhan</li> <li> Immunosuppressive agents such as glucocorticoids, IVIG, tocilizumab, anakinra, and JAK inhibitors could be considered for treatment in patients with evidence of hyperinflammation</li> </ul> <p>\ </p>}, language = {English}, number = {10229}, urldate = {2020-04-25}, journal = {The Lancet}, author = {Mehta, Puja and McAuley, Daniel F. and Brown, Michael and Sanchez, Emilie and Tattersall, Rachel S. and Manson, Jessica J.}, month = mar, year = {2020}, pmid = {32192578}, keywords = {Shradha Kulkarni}, pages = {1033--1034}, annote = {1-liner: This correspondence letter published in The Lancet recommends identifying and treating hyperinflammation, such as secondary HLH, in severe COVID-19. Summary Article type – correspondence letter Main takeaways: - Severe COVID-19 disease appears to be associated with a cytokine profile resembling secondary HLH, “characterized by increased interleukin (IL)-2, IL-7, granulocyte-colony stimulating factor, interferon-γ inducible protein 10, monocyte chemo-attractant protein 1, macrophage inflammatory protein 1-α, and tumour necrosis factor-α” - Elevated ferritin and IL-6, which may suggest “hyperinflammation,” were found to be predictors of fatality from a retrospective study of 150 COVID-19 cases in Wuhan - Immunosuppressive agents such as glucocorticoids, IVIG, tocilizumab, anakinra, and JAK inhibitors could be considered for treatment in patients with evidence of hyperinflammation }, file = {Snapshot:C\:\\Users\\mdwan\\Zotero\\storage\\SQE4P4Q2\\Mehta et al. - 2020 - COVID-19 consider cytokine storm syndromes and im.html:text/html} }