In-vivo identification and control of aerotaxis in Bacillus subtilis. Menolascina, F., Stocker, R., & Sontag, E. In Proc. IEEE Conf. Decision and Control, Dec. 2016, pages 764-769, 2016.
abstract   bibtex   
Combining in-vivo experiments with system identification methods, we determine a simple model of aerotaxis in B. subtilis, and we subsequently employ this model in order to compute the sequence of oxygen gradients needed in order to achieve set-point regulation with respect to a signal tracking the center of mass of the bacterial population. We then successfully validate both the model and the control scheme, by showing that in-vivo positioning control can be achieved via the application of the precomputed inputs in-vivo in an open-loop configuration.
@INPROCEEDINGS{16cdc_menolascina,
   AUTHOR       = {F. Menolascina and R. Stocker and E.D. Sontag},
   BOOKTITLE    = {Proc. IEEE Conf. Decision and Control, Dec. 2016},
   TITLE        = {In-vivo identification and control of aerotaxis in 
      Bacillus subtilis},
   YEAR         = {2016},
   OPTADDRESS   = {},
   OPTCROSSREF  = {},
   OPTEDITOR    = {},
   OPTMONTH     = {},
   OPTNOTE      = {},
   OPTNUMBER    = {},
   OPTORGANIZATION = {},
   PAGES        = {764-769},
   OPTPUBLISHER = {},
   OPTSERIES    = {},
   OPTVOLUME    = {},
   KEYWORDS     = {identification, systems biology, aerotaxis, B. subtilis},
   PDF          = {../../FTPDIR/2016cdc_menolascina_stocker_sontag_as_published.pdf},
   ABSTRACT     = {Combining in-vivo experiments with system identification 
      methods, we determine a simple model of aerotaxis in B. subtilis, and 
      we subsequently employ this model in order to compute the sequence of 
      oxygen gradients needed in order to achieve set-point regulation with 
      respect to a signal tracking the center of mass of the bacterial 
      population. We then successfully validate both the model and the 
      control scheme, by showing that in-vivo positioning control can be 
      achieved via the application of the precomputed inputs in-vivo in an 
      open-loop configuration.}
}
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