@article{merad_pathological_2020, title = {Pathological inflammation in patients with {COVID}-19: a key role for monocytes and macrophages}, volume = {20}, copyright = {2020 Springer Nature Limited}, issn = {1474-1741}, shorttitle = {Pathological inflammation in patients with {COVID}-19}, url = {https://www.nature.com/articles/s41577-020-0331-4}, doi = {10.1038/s41577-020-0331-4}, abstract = {The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.}, language = {en}, number = {6}, urldate = {2020-06-21}, journal = {Nature Reviews Immunology}, author = {Merad, Miriam and Martin, Jerome C.}, month = jun, year = {2020}, note = {Number: 6 Publisher: Nature Publishing Group}, keywords = {Monocytes, cytokine, hyperactivation, hyperinflammation, macrophages}, pages = {355--362}, }