{"_id":"J4pTs2pemb2rPjByf","bibbaseid":"merad-martin-pathologicalinflammationinpatientswithcovid19akeyroleformonocytesandmacrophages-2020","authorIDs":[],"author_short":["Merad, M.","Martin, J. C."],"bibdata":{"bibtype":"article","type":"article","title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","copyright":"2020 Springer Nature Limited","issn":"1474-1741","shorttitle":"Pathological inflammation in patients with COVID-19","url":"https://www.nature.com/articles/s41577-020-0331-4","doi":"10.1038/s41577-020-0331-4","abstract":"The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.","language":"en","number":"6","urldate":"2020-06-21","journal":"Nature Reviews Immunology","author":[{"propositions":[],"lastnames":["Merad"],"firstnames":["Miriam"],"suffixes":[]},{"propositions":[],"lastnames":["Martin"],"firstnames":["Jerome","C."],"suffixes":[]}],"month":"June","year":"2020","note":"Number: 6 Publisher: Nature Publishing Group","keywords":"Monocytes, cytokine, hyperactivation, hyperinflammation, macrophages","pages":"355–362","bibtex":"@article{merad_pathological_2020,\n\ttitle = {Pathological inflammation in patients with {COVID}-19: a key role for monocytes and macrophages},\n\tvolume = {20},\n\tcopyright = {2020 Springer Nature Limited},\n\tissn = {1474-1741},\n\tshorttitle = {Pathological inflammation in patients with {COVID}-19},\n\turl = {https://www.nature.com/articles/s41577-020-0331-4},\n\tdoi = {10.1038/s41577-020-0331-4},\n\tabstract = {The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.},\n\tlanguage = {en},\n\tnumber = {6},\n\turldate = {2020-06-21},\n\tjournal = {Nature Reviews Immunology},\n\tauthor = {Merad, Miriam and Martin, Jerome C.},\n\tmonth = jun,\n\tyear = {2020},\n\tnote = {Number: 6\nPublisher: Nature Publishing Group},\n\tkeywords = {Monocytes, cytokine, hyperactivation, hyperinflammation, macrophages},\n\tpages = {355--362},\n}\n\n","author_short":["Merad, M.","Martin, J. C."],"key":"merad_pathological_2020","id":"merad_pathological_2020","bibbaseid":"merad-martin-pathologicalinflammationinpatientswithcovid19akeyroleformonocytesandmacrophages-2020","role":"author","urls":{"Paper":"https://www.nature.com/articles/s41577-020-0331-4"},"keyword":["Monocytes","cytokine","hyperactivation","hyperinflammation","macrophages"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/groups/2460320/items?key=44Dtrbvg3m3qVzsbKTYBPwX5&format=bibtex&limit=100","creationDate":"2020-06-29T08:45:38.093Z","downloads":0,"keywords":["monocytes","cytokine","hyperactivation","hyperinflammation","macrophages"],"search_terms":["pathological","inflammation","patients","covid","key","role","monocytes","macrophages","merad","martin"],"title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","year":2020,"dataSources":["5J9BKY7KegCaupqgz"]}