Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. Merelo, P., Ram, H., Pia Caggiano, M., Ohno, C., Ott, F., Straub, D., Graeff, M., Cho, S. K., Yang, S. W., Wenkel, S., & Heisler, M. G. Proceedings of the National Academy of Sciences, 113(42):11973–11978, October, 2016.

Paper doi abstract bibtex

A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial–abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.

@article{merelo_regulation_2016,
	title = {Regulation of {MIR165}/166 by class {II} and class {III} homeodomain leucine zipper proteins establishes leaf polarity},
	volume = {113},
	url = {https://www.pnas.org/doi/10.1073/pnas.1516110113},
	doi = {10.1073/pnas.1516110113},
	abstract = {A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial–abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.},
	number = {42},
	urldate = {2022-11-30},
	journal = {Proceedings of the National Academy of Sciences},
	author = {Merelo, Paz and Ram, Hathi and Pia Caggiano, Monica and Ohno, Carolyn and Ott, Felix and Straub, Daniel and Graeff, Moritz and Cho, Seok Keun and Yang, Seong Wook and Wenkel, Stephan and Heisler, Marcus G.},
	month = oct,
	year = {2016},
	pages = {11973--11978},
}

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