Hemocompatibility of Poly(vinyl alcohol)-Gelatin Core-Shell Electrospun Nanofibers: A Scaffold for Modulating Platelet Deposition and Activation. Merkle, V. M.; Martin, D.; Hutchinson, M.; Tran, P. L.; Behrens, A.; Hossainy, S.; Sheriff, J.; Bluestein, D.; Wu, X.; and Slepian, M. J. ACS Appl. Mater. Interfaces, 7:8302-12, 2015.
Hemocompatibility of Poly(vinyl alcohol)-Gelatin Core-Shell Electrospun Nanofibers: A Scaffold for Modulating Platelet Deposition and Activation [link]Link  abstract   bibtex   
In this study, we evaluate coaxial electrospun nanofibers with gelatin in the shell and poly(vinyl alcohol) (PVA) in the core as a potential vascular material by determining fiber surface roughness, as well as human platelet deposition and activation under varying conditions. PVA scaffolds had the highest surface roughness (Ra=65.5+/-6.8 nm) but the lowest platelet deposition (34.2+/-5.8 platelets) in comparison to gelatin nanofibers (Ra=36.8+/-3.0 nm and 168.9+/-29.8 platelets) and coaxial nanofibers (1 Gel:1 PVA coaxial, Ra=24.0+/-1.5 nm and 150.2+/-17.4 platelets. 3 Gel:1 PVA coaxial, Ra=37.1+/-2.8 nm and 167.8+/-15.4 platelets). Therefore, the chemical structure of the gelatin nanofibers dominated surface roughness in platelet deposition. Due to their increased stiffness, the coaxial nanofibers had the highest platelet activation rate, rate of thrombin formation, in comparison to gelatin and PVA fibers. Our studies indicate that mechanical stiffness is a dominating factor for platelet deposition and activation, followed by biochemical signals, and lastly surface roughness. Overall, these coaxial nanofibers are an appealing material for vascular applications by supporting cellular growth while minimizing platelet deposition and activation.
@article{z14,
 author = {Merkle, V. M. and Martin, D. and Hutchinson, M. and Tran, P. L. and Behrens, A. and Hossainy, S. and Sheriff, J. and Bluestein, D. and Wu, X. and Slepian, M. J.},
 year = {2015},
 title = {Hemocompatibility of Poly(vinyl alcohol)-Gelatin Core-Shell Electrospun Nanofibers: A Scaffold for Modulating Platelet Deposition and Activation},
 journal = {ACS Appl. Mater. Interfaces},
 volume = {7},
 issue = {15},
 pages = {8302-12},
 url_Link = {https://doi.org/10.1021/acsami.5b01671},
 abstract = {In this study, we evaluate coaxial electrospun nanofibers with gelatin in the shell and poly(vinyl alcohol) (PVA) in the core as a potential vascular material by determining fiber surface roughness, as well as human platelet deposition and activation under varying conditions. PVA scaffolds had the highest surface roughness (Ra=65.5+/-6.8 nm) but the lowest platelet deposition (34.2+/-5.8 platelets) in comparison to gelatin nanofibers (Ra=36.8+/-3.0 nm and 168.9+/-29.8 platelets) and coaxial nanofibers (1 Gel:1 PVA coaxial, Ra=24.0+/-1.5 nm and 150.2+/-17.4 platelets. 3 Gel:1 PVA coaxial, Ra=37.1+/-2.8 nm and 167.8+/-15.4 platelets). Therefore, the chemical structure of the gelatin nanofibers dominated surface roughness in platelet deposition. Due to their increased stiffness, the coaxial nanofibers had the highest platelet activation rate, rate of thrombin formation, in comparison to gelatin and PVA fibers. Our studies indicate that mechanical stiffness is a dominating factor for platelet deposition and activation, followed by biochemical signals, and lastly surface roughness. Overall, these coaxial nanofibers are an appealing material for vascular applications by supporting cellular growth while minimizing platelet deposition and activation.},
 type = {1. Peer-Reviewed Journal Papers}
}
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