G-quadruplexes in RNA biology. Millevoi, S., Moine, H., & Vagner, S. Wiley interdisciplinary reviews. RNA, 3(4):495–507, 2012. ![G-quadruplexes in RNA biology. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex G-quadruplexes are noncanonical structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. Experimental studies and computational predictions show that RNA G-quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G-quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G-quadruplexes appear as important regulators of pre-mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G-quadruplexes involve the binding of protein factors that modulate G-quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G-quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions.
@article{Millevoi2012,
title = {G-quadruplexes in {RNA} biology.},
volume = {3},
issn = {1757-7012},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22488917},
doi = {10.1002/wrna.1113},
abstract = {G-quadruplexes are noncanonical structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. Experimental studies and computational predictions show that RNA G-quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G-quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G-quadruplexes appear as important regulators of pre-mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G-quadruplexes involve the binding of protein factors that modulate G-quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G-quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions.},
number = {4},
journal = {Wiley interdisciplinary reviews. RNA},
author = {Millevoi, Stefania and Moine, Hervé and Vagner, Stéphan},
year = {2012},
pmid = {22488917},
keywords = {\#nosource, G-Quadruplexes, Genetic, Humans, Polyadenylation, RNA, RNA Splicing, RNA: chemistry, RNA: metabolism, Telomere, Telomere: metabolism, Transcription},
pages = {495--507},
}
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