@article{minney-smith_intussusception_2014,
	title = {Intussusception is associated with the detection of adenovirus {C}, enterovirus {B} and rotavirus in a rotavirus vaccinated population},
	volume = {61},
	issn = {1386-6532},
	url = {http://www.sciencedirect.com/science/article/pii/S1386653214004053},
	doi = {10.1016/j.jcv.2014.10.018},
	abstract = {AbstractBackground
Intussusception, a condition where one segment of intestine invaginates into another, occurs predominantly in infants and young children. A number of potential causes have been identified including infectious agents and rotavirus vaccination. Following the introduction of rotavirus vaccination of infants in Western Australia, a laboratory surveillance programme testing notified intussusception cases for infectious agents was commenced. This led to a PCR-based study of the association between gastrointestinal viruses and intussusception.
Objectives
Conduct viral testing on stool samples from intussusception patients to determine viruses that may have an association with intussusception.
Study design
A retrospective case–control study was conducted using stool samples collected from children with intussusception (n = 74) and matched controls (n = 289) between 2008 and 2011. Samples were tested for rotavirus, norovirus, adenovirus, enterovirus, rhinovirus, astrovirus, parechovirus and bocavirus. Adenovirus, enterovirus and rhinovirus species were determined by DNA sequencing.
Results
Human adenovirus C was detected in significantly more cases than controls with 31/74 (41.9\%) cases testing positive compared to 39/289 (13.49\%) controls (OR = 4.38, p \< 0.001). A significant difference was seen in Enterovirus B detections with 11/74 (14.9\%) cases testing positive compared to 21/289 (7.3\%) controls (OR = 2.24, p = 0.04). Rotavirus was detected in 7/74 (9.46\%) cases and 11/289 (3.81\%) controls, which was also a significant difference (OR = 2.88, p = 0.045).
Conclusions
Our results show that intussusception is associated with non-enteric adenovirus infections, and Enterovirus B infections. While a statistical association was seen with rotavirus and intussusception, we were not able to determine if this was related to vaccine strain or wild type rotavirus.},
	number = {4},
	urldate = {2014-12-04},
	journal = {Journal of Clinical Virology},
	author = {Minney-Smith, Cara A. and Levy, Avram and Hodge, Meredith and Jacoby, Peter and Williams, Simon H. and Carcione, Dale and Roczo-Farkas, Susie and Kirkwood, Carl D. and Smith, David W.},
	month = dec,
	year = {2014},
	keywords = {Adenovirus, Adenoviruses, Human/*isolation \& purification, Case-Control Studies, Child, Preschool, Enterovirus, Enterovirus B, Human/*isolation \& purification, Feces/*virology, Female, Humans, Infant, Infant, Newborn, Intussusception, Intussusception/*epidemiology/*virology, Male, Retrospective Studies, Rotavirus Vaccines/administration \& dosage/*adverse effects, Rotavirus/*isolation \& purification, Sequence Analysis, DNA, Western Australia, polymerase chain reaction, rotavirus},
	pages = {579--584},
}

{"_id":"gRTToL679Wazzz7N9","bibbaseid":"minneysmith-levy-hodge-jacoby-williams-carcione-roczofarkas-kirkwood-etal-intussusceptionisassociatedwiththedetectionofadenoviruscenterovirusbandrotavirusinarotavirusvaccinatedpopulation-2014","author_short":["Minney-Smith, C. A.","Levy, A.","Hodge, M.","Jacoby, P.","Williams, S. H.","Carcione, D.","Roczo-Farkas, S.","Kirkwood, C. D.","Smith, D. W."],"bibdata":{"bibtype":"article","type":"article","title":"Intussusception is associated with the detection of adenovirus C, enterovirus B and rotavirus in a rotavirus vaccinated population","volume":"61","issn":"1386-6532","url":"http://www.sciencedirect.com/science/article/pii/S1386653214004053","doi":"10.1016/j.jcv.2014.10.018","abstract":"AbstractBackground Intussusception, a condition where one segment of intestine invaginates into another, occurs predominantly in infants and young children. A number of potential causes have been identified including infectious agents and rotavirus vaccination. Following the introduction of rotavirus vaccination of infants in Western Australia, a laboratory surveillance programme testing notified intussusception cases for infectious agents was commenced. This led to a PCR-based study of the association between gastrointestinal viruses and intussusception. Objectives Conduct viral testing on stool samples from intussusception patients to determine viruses that may have an association with intussusception. Study design A retrospective case–control study was conducted using stool samples collected from children with intussusception (n = 74) and matched controls (n = 289) between 2008 and 2011. Samples were tested for rotavirus, norovirus, adenovirus, enterovirus, rhinovirus, astrovirus, parechovirus and bocavirus. Adenovirus, enterovirus and rhinovirus species were determined by DNA sequencing. Results Human adenovirus C was detected in significantly more cases than controls with 31/74 (41.9%) cases testing positive compared to 39/289 (13.49%) controls (OR = 4.38, p < 0.001). A significant difference was seen in Enterovirus B detections with 11/74 (14.9%) cases testing positive compared to 21/289 (7.3%) controls (OR = 2.24, p = 0.04). Rotavirus was detected in 7/74 (9.46%) cases and 11/289 (3.81%) controls, which was also a significant difference (OR = 2.88, p = 0.045). Conclusions Our results show that intussusception is associated with non-enteric adenovirus infections, and Enterovirus B infections. While a statistical association was seen with rotavirus and intussusception, we were not able to determine if this was related to vaccine strain or wild type rotavirus.","number":"4","urldate":"2014-12-04","journal":"Journal of Clinical Virology","author":[{"propositions":[],"lastnames":["Minney-Smith"],"firstnames":["Cara","A."],"suffixes":[]},{"propositions":[],"lastnames":["Levy"],"firstnames":["Avram"],"suffixes":[]},{"propositions":[],"lastnames":["Hodge"],"firstnames":["Meredith"],"suffixes":[]},{"propositions":[],"lastnames":["Jacoby"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Williams"],"firstnames":["Simon","H."],"suffixes":[]},{"propositions":[],"lastnames":["Carcione"],"firstnames":["Dale"],"suffixes":[]},{"propositions":[],"lastnames":["Roczo-Farkas"],"firstnames":["Susie"],"suffixes":[]},{"propositions":[],"lastnames":["Kirkwood"],"firstnames":["Carl","D."],"suffixes":[]},{"propositions":[],"lastnames":["Smith"],"firstnames":["David","W."],"suffixes":[]}],"month":"December","year":"2014","keywords":"Adenovirus, Adenoviruses, Human/*isolation & purification, Case-Control Studies, Child, Preschool, Enterovirus, Enterovirus B, Human/*isolation & purification, Feces/*virology, Female, Humans, Infant, Infant, Newborn, Intussusception, Intussusception/*epidemiology/*virology, Male, Retrospective Studies, Rotavirus Vaccines/administration & dosage/*adverse effects, Rotavirus/*isolation & purification, Sequence Analysis, DNA, Western Australia, polymerase chain reaction, rotavirus","pages":"579–584","bibtex":"@article{minney-smith_intussusception_2014,\n\ttitle = {Intussusception is associated with the detection of adenovirus {C}, enterovirus {B} and rotavirus in a rotavirus vaccinated population},\n\tvolume = {61},\n\tissn = {1386-6532},\n\turl = {http://www.sciencedirect.com/science/article/pii/S1386653214004053},\n\tdoi = {10.1016/j.jcv.2014.10.018},\n\tabstract = {AbstractBackground\nIntussusception, a condition where one segment of intestine invaginates into another, occurs predominantly in infants and young children. A number of potential causes have been identified including infectious agents and rotavirus vaccination. Following the introduction of rotavirus vaccination of infants in Western Australia, a laboratory surveillance programme testing notified intussusception cases for infectious agents was commenced. This led to a PCR-based study of the association between gastrointestinal viruses and intussusception.\nObjectives\nConduct viral testing on stool samples from intussusception patients to determine viruses that may have an association with intussusception.\nStudy design\nA retrospective case–control study was conducted using stool samples collected from children with intussusception (n = 74) and matched controls (n = 289) between 2008 and 2011. Samples were tested for rotavirus, norovirus, adenovirus, enterovirus, rhinovirus, astrovirus, parechovirus and bocavirus. Adenovirus, enterovirus and rhinovirus species were determined by DNA sequencing.\nResults\nHuman adenovirus C was detected in significantly more cases than controls with 31/74 (41.9\\%) cases testing positive compared to 39/289 (13.49\\%) controls (OR = 4.38, p \\< 0.001). A significant difference was seen in Enterovirus B detections with 11/74 (14.9\\%) cases testing positive compared to 21/289 (7.3\\%) controls (OR = 2.24, p = 0.04). Rotavirus was detected in 7/74 (9.46\\%) cases and 11/289 (3.81\\%) controls, which was also a significant difference (OR = 2.88, p = 0.045).\nConclusions\nOur results show that intussusception is associated with non-enteric adenovirus infections, and Enterovirus B infections. While a statistical association was seen with rotavirus and intussusception, we were not able to determine if this was related to vaccine strain or wild type rotavirus.},\n\tnumber = {4},\n\turldate = {2014-12-04},\n\tjournal = {Journal of Clinical Virology},\n\tauthor = {Minney-Smith, Cara A. and Levy, Avram and Hodge, Meredith and Jacoby, Peter and Williams, Simon H. and Carcione, Dale and Roczo-Farkas, Susie and Kirkwood, Carl D. and Smith, David W.},\n\tmonth = dec,\n\tyear = {2014},\n\tkeywords = {Adenovirus, Adenoviruses, Human/*isolation \\& purification, Case-Control Studies, Child, Preschool, Enterovirus, Enterovirus B, Human/*isolation \\& purification, Feces/*virology, Female, Humans, Infant, Infant, Newborn, Intussusception, Intussusception/*epidemiology/*virology, Male, Retrospective Studies, Rotavirus Vaccines/administration \\& dosage/*adverse effects, Rotavirus/*isolation \\& purification, Sequence Analysis, DNA, Western Australia, polymerase chain reaction, rotavirus},\n\tpages = {579--584},\n}\n\n","author_short":["Minney-Smith, C. A.","Levy, A.","Hodge, M.","Jacoby, P.","Williams, S. H.","Carcione, D.","Roczo-Farkas, S.","Kirkwood, C. D.","Smith, D. W."],"key":"minney-smith_intussusception_2014","id":"minney-smith_intussusception_2014","bibbaseid":"minneysmith-levy-hodge-jacoby-williams-carcione-roczofarkas-kirkwood-etal-intussusceptionisassociatedwiththedetectionofadenoviruscenterovirusbandrotavirusinarotavirusvaccinatedpopulation-2014","role":"author","urls":{"Paper":"http://www.sciencedirect.com/science/article/pii/S1386653214004053"},"keyword":["Adenovirus","Adenoviruses","Human/*isolation & purification","Case-Control Studies","Child","Preschool","Enterovirus","Enterovirus B","Human/*isolation & purification","Feces/*virology","Female","Humans","Infant","Infant","Newborn","Intussusception","Intussusception/*epidemiology/*virology","Male","Retrospective Studies","Rotavirus Vaccines/administration & dosage/*adverse effects","Rotavirus/*isolation & purification","Sequence Analysis","DNA","Western Australia","polymerase chain reaction","rotavirus"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":["adenovirus","adenoviruses","human/*isolation & purification","case-control studies","child","preschool","enterovirus","enterovirus b","human/*isolation & purification","feces/*virology","female","humans","infant","infant","newborn","intussusception","intussusception/*epidemiology/*virology","male","retrospective studies","rotavirus vaccines/administration & dosage/*adverse effects","rotavirus/*isolation & purification","sequence analysis","dna","western australia","polymerase chain reaction","rotavirus"],"search_terms":["intussusception","associated","detection","adenovirus","enterovirus","rotavirus","rotavirus","vaccinated","population","minney-smith","levy","hodge","jacoby","williams","carcione","roczo-farkas","kirkwood","smith"],"title":"Intussusception is associated with the detection of adenovirus C, enterovirus B and rotavirus in a rotavirus vaccinated population","year":2014}