Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. Minoshima, R, Kosugi, S, Nishimura, D, Ihara, N, Seki, H, Yamada, T, Watanabe, K, Katori, N, Hashiguchi, S, & Morisaki, H Acta Anaesthesiologica Scandinavica, 59(10):1260–1268, November, 2015. ![Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND:In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery. METHODS:After IRB approval and informed consent, 36 patients, aged 10-19 years, undergoing posterior correction surgery for adolescent idiopathic scoliosis, were randomly allocated into two groups: intra- and postoperative ketamine infusion at a rate of 2 μg/kg/min until 48 h after surgery (ketamine group, n = 17) or infusion of an equal volume of saline (placebo group, n = 19). All patients were administered total intravenous anesthesia with propofol and remifentanil during surgery and intravenous morphine using a patient-controlled analgesia device after surgery. The primary outcome was cumulative morphine consumption in the initial 48 h after surgery. Pain scores (Numerical Rating Scale, NRS, 0-10), sedation scales, incidence of postoperative nausea and vomiting (PONV), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48 h after surgery. RESULTS:Patient characteristics did not differ between the two groups. Cumulative morphine consumption for 48 h after surgery was significantly lower in the ketamine group compared to the placebo group (0.89 ± 0.08 mg/kg vs. 1.16 ± 0.07 mg/kg, 95% confidence interval for difference between the means, 0.03-0.48 mg/kg, P = 0.019). NRS pain, sedation scales, and incidence of PONV did not differ between the two groups. Antiemetic consumption was significantly smaller in ketamine group. CONCLUSIONS:Intra- and postoperative infusion of low-dose ketamine reduced cumulative morphine consumption and antiemetic requirement for 48 h after surgery.
@article{minoshima_intra-_2015,
title = {Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.},
volume = {59},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26079533&retmode=ref&cmd=prlinks},
doi = {10.1111/aas.12571},
abstract = {BACKGROUND:In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery. METHODS:After IRB approval and informed consent, 36 patients, aged 10-19 years, undergoing posterior correction surgery for adolescent idiopathic scoliosis, were randomly allocated into two groups: intra- and postoperative ketamine infusion at a rate of 2 μg/kg/min until 48 h after surgery (ketamine group, n = 17) or infusion of an equal volume of saline (placebo group, n = 19). All patients were administered total intravenous anesthesia with propofol and remifentanil during surgery and intravenous morphine using a patient-controlled analgesia device after surgery. The primary outcome was cumulative morphine consumption in the initial 48 h after surgery. Pain scores (Numerical Rating Scale, NRS, 0-10), sedation scales, incidence of postoperative nausea and vomiting (PONV), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48 h after surgery. RESULTS:Patient characteristics did not differ between the two groups. Cumulative morphine consumption for 48 h after surgery was significantly lower in the ketamine group compared to the placebo group (0.89 ± 0.08 mg/kg vs. 1.16 ± 0.07 mg/kg, 95\% confidence interval for difference between the means, 0.03-0.48 mg/kg, P = 0.019). NRS pain, sedation scales, and incidence of PONV did not differ between the two groups. Antiemetic consumption was significantly smaller in ketamine group. CONCLUSIONS:Intra- and postoperative infusion of low-dose ketamine reduced cumulative morphine consumption and antiemetic requirement for 48 h after surgery.},
number = {10},
journal = {Acta Anaesthesiologica Scandinavica},
author = {Minoshima, R and Kosugi, S and Nishimura, D and Ihara, N and Seki, H and Yamada, T and Watanabe, K and Katori, N and Hashiguchi, S and Morisaki, H},
month = nov,
year = {2015},
pages = {1260--1268},
}
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{"_id":"LZwdqvm7W5mKypXAY","bibbaseid":"minoshima-kosugi-nishimura-ihara-seki-yamada-watanabe-katori-etal-intraandpostoperativelowdoseketamineforadolescentidiopathicscoliosissurgeryarandomizedcontrolledtrial-2015","downloads":0,"creationDate":"2017-05-12T19:33:45.416Z","title":"Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.","author_short":["Minoshima, R","Kosugi, S","Nishimura, D","Ihara, N","Seki, H","Yamada, T","Watanabe, K","Katori, N","Hashiguchi, S","Morisaki, H"],"year":2015,"bibtype":"article","biburl":"http://bibbase.org/zotero-group/gxu917/1345589","bibdata":{"bibtype":"article","type":"article","title":"Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.","volume":"59","url":"http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26079533&retmode=ref&cmd=prlinks","doi":"10.1111/aas.12571","abstract":"BACKGROUND:In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery. METHODS:After IRB approval and informed consent, 36 patients, aged 10-19 years, undergoing posterior correction surgery for adolescent idiopathic scoliosis, were randomly allocated into two groups: intra- and postoperative ketamine infusion at a rate of 2 μg/kg/min until 48 h after surgery (ketamine group, n = 17) or infusion of an equal volume of saline (placebo group, n = 19). All patients were administered total intravenous anesthesia with propofol and remifentanil during surgery and intravenous morphine using a patient-controlled analgesia device after surgery. The primary outcome was cumulative morphine consumption in the initial 48 h after surgery. Pain scores (Numerical Rating Scale, NRS, 0-10), sedation scales, incidence of postoperative nausea and vomiting (PONV), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48 h after surgery. RESULTS:Patient characteristics did not differ between the two groups. Cumulative morphine consumption for 48 h after surgery was significantly lower in the ketamine group compared to the placebo group (0.89 ± 0.08 mg/kg vs. 1.16 ± 0.07 mg/kg, 95% confidence interval for difference between the means, 0.03-0.48 mg/kg, P = 0.019). NRS pain, sedation scales, and incidence of PONV did not differ between the two groups. Antiemetic consumption was significantly smaller in ketamine group. CONCLUSIONS:Intra- and postoperative infusion of low-dose ketamine reduced cumulative morphine consumption and antiemetic requirement for 48 h after surgery.","number":"10","journal":"Acta Anaesthesiologica Scandinavica","author":[{"propositions":[],"lastnames":["Minoshima"],"firstnames":["R"],"suffixes":[]},{"propositions":[],"lastnames":["Kosugi"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Nishimura"],"firstnames":["D"],"suffixes":[]},{"propositions":[],"lastnames":["Ihara"],"firstnames":["N"],"suffixes":[]},{"propositions":[],"lastnames":["Seki"],"firstnames":["H"],"suffixes":[]},{"propositions":[],"lastnames":["Yamada"],"firstnames":["T"],"suffixes":[]},{"propositions":[],"lastnames":["Watanabe"],"firstnames":["K"],"suffixes":[]},{"propositions":[],"lastnames":["Katori"],"firstnames":["N"],"suffixes":[]},{"propositions":[],"lastnames":["Hashiguchi"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Morisaki"],"firstnames":["H"],"suffixes":[]}],"month":"November","year":"2015","pages":"1260–1268","bibtex":"@article{minoshima_intra-_2015,\n\ttitle = {Intra- and postoperative low-dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial.},\n\tvolume = {59},\n\turl = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26079533&retmode=ref&cmd=prlinks},\n\tdoi = {10.1111/aas.12571},\n\tabstract = {BACKGROUND:In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose ketamine decreased postoperative morphine requirement and morphine-related adverse effects as nausea and vomiting after scoliosis surgery. METHODS:After IRB approval and informed consent, 36 patients, aged 10-19 years, undergoing posterior correction surgery for adolescent idiopathic scoliosis, were randomly allocated into two groups: intra- and postoperative ketamine infusion at a rate of 2 μg/kg/min until 48 h after surgery (ketamine group, n = 17) or infusion of an equal volume of saline (placebo group, n = 19). All patients were administered total intravenous anesthesia with propofol and remifentanil during surgery and intravenous morphine using a patient-controlled analgesia device after surgery. The primary outcome was cumulative morphine consumption in the initial 48 h after surgery. Pain scores (Numerical Rating Scale, NRS, 0-10), sedation scales, incidence of postoperative nausea and vomiting (PONV), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48 h after surgery. RESULTS:Patient characteristics did not differ between the two groups. Cumulative morphine consumption for 48 h after surgery was significantly lower in the ketamine group compared to the placebo group (0.89 ± 0.08 mg/kg vs. 1.16 ± 0.07 mg/kg, 95\\% confidence interval for difference between the means, 0.03-0.48 mg/kg, P = 0.019). NRS pain, sedation scales, and incidence of PONV did not differ between the two groups. Antiemetic consumption was significantly smaller in ketamine group. CONCLUSIONS:Intra- and postoperative infusion of low-dose ketamine reduced cumulative morphine consumption and antiemetic requirement for 48 h after surgery.},\n\tnumber = {10},\n\tjournal = {Acta Anaesthesiologica Scandinavica},\n\tauthor = {Minoshima, R and Kosugi, S and Nishimura, D and Ihara, N and Seki, H and Yamada, T and Watanabe, K and Katori, N and Hashiguchi, S and Morisaki, H},\n\tmonth = nov,\n\tyear = {2015},\n\tpages = {1260--1268},\n}\n\n\n\n","author_short":["Minoshima, R","Kosugi, S","Nishimura, D","Ihara, N","Seki, H","Yamada, T","Watanabe, K","Katori, N","Hashiguchi, S","Morisaki, H"],"key":"minoshima_intra-_2015","id":"minoshima_intra-_2015","bibbaseid":"minoshima-kosugi-nishimura-ihara-seki-yamada-watanabe-katori-etal-intraandpostoperativelowdoseketamineforadolescentidiopathicscoliosissurgeryarandomizedcontrolledtrial-2015","role":"author","urls":{"Paper":"http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26079533&retmode=ref&cmd=prlinks"},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["intra","postoperative","low","dose","ketamine","adolescent","idiopathic","scoliosis","surgery","randomized","controlled","trial","minoshima","kosugi","nishimura","ihara","seki","yamada","watanabe","katori","hashiguchi","morisaki"],"keywords":[],"authorIDs":[],"dataSources":["4P4hKw3sZj97Zz2kx"]}