Genome technologies in pulmonology: A role of microRNA in asthma and COPD development. Mironova, Z., D'Yachenko, N., Ulitina, A., Trofimov, V., Pchelina, S., & Dubina, M. Pulmonologiya, 26(1):5-11, Medical Education, 2016. cited By 0
Genome technologies in pulmonology: A role of microRNA in asthma and COPD development [link]Paper  doi  abstract   bibtex   
MicroRNAs (miRNAs) are small noncoding RNA molecules that affect gene expression and thus take part in the epigenetic regulation of almost all physiological and pathological processes. About 1,800 human miRNAs have been discovered to date; however, biological functions and protein tar-gets for the majority remain to be unknown. Within the respiratory system, miRNAs contribute to the lung growth and lifelong maintenance of pul-monary homeostasis. Recently, the leading role of miRNAs in pathogenesis of various pulmonary diseases has been found, including asthma, chron-ic obstructive pulmonary disease (COPD) and lung cancer. Due to a significant progress in studying interactions between genes and their products and environmental factors, a great role of epigenetic variability, which is gene expression change not related to DNA damage, but could be inherited con-sistently, became apparent. There are three levels of epigenetic regulation corresponding to three main mechanisms: genomic (DNA methylation), proteomic (histone modification) and transcriptomic (regulation through RNA, primarily miRNA). Extending our knowledge on a role of miRNAs for the respiratory system could open new therapeutic targets and diagnostic markers for respiratory diseases, particularly asthma and COPD.
@ARTICLE{Mironova20165,
author={Mironova, Zh.A. and D'Yachenko, N.A. and Ulitina, A.S. and Trofimov, V.I. and Pchelina, S.N. and Dubina, M.V.},
title={Genome technologies in pulmonology: A role of microRNA in asthma and COPD development},
journal={Pulmonologiya},
year={2016},
volume={26},
number={1},
pages={5-11},
doi={10.18093/0869-0189-2016-26-1-5-11},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046242372&doi=10.18093%2f0869-0189-2016-26-1-5-11&partnerID=40&md5=94dc10f1680b964748b362aa9bd83cab},
affiliation={Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia, 6 / 8, L'va Tolstogo str, Saint-Petersburg, 197089, Russian Federation; Saint-Petersburg Federal National Research Academic University of Russian Science Academy, Ministry of Education and Science of Russia: 8 / 3, Khlopina str, Saint-Petersburg, 194021, Russian Federation},
abstract={MicroRNAs (miRNAs) are small noncoding RNA molecules that affect gene expression and thus take part in the epigenetic regulation of almost all physiological and pathological processes. About 1,800 human miRNAs have been discovered to date; however, biological functions and protein tar-gets for the majority remain to be unknown. Within the respiratory system, miRNAs contribute to the lung growth and lifelong maintenance of pul-monary homeostasis. Recently, the leading role of miRNAs in pathogenesis of various pulmonary diseases has been found, including asthma, chron-ic obstructive pulmonary disease (COPD) and lung cancer. Due to a significant progress in studying interactions between genes and their products and environmental factors, a great role of epigenetic variability, which is gene expression change not related to DNA damage, but could be inherited con-sistently, became apparent. There are three levels of epigenetic regulation corresponding to three main mechanisms: genomic (DNA methylation), proteomic (histone modification) and transcriptomic (regulation through RNA, primarily miRNA). Extending our knowledge on a role of miRNAs for the respiratory system could open new therapeutic targets and diagnostic markers for respiratory diseases, particularly asthma and COPD.},
author_keywords={Asthma;  Chronic Obstructive Pulmonary Disease;  Cigarette Smoke;  Environment;  Epigenetic regulation;  Immune Response;  Micrornas},
publisher={Medical Education},
issn={08690189},
language={Russian},
abbrev_source_title={Pulmonologiya},
document_type={Review},
source={Scopus},
}
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