Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue. Miroshnikova, V., Panteleeva, A., Bazhenova, E., Demina, E., Usenko, T., Nikolaev, M., Semenova, I., Neimark, A., He, J., Belyaeva, O., Berkovich, O., Baranova, E., & Pchelina, S. Biomeditsinskaya Khimiya, 62(3):283-289, Russian Academy of Medical Sciences, 2016. cited By 2
Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue [link]Paper  doi  abstract   bibtex   
Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis - LXRa, LXRp, PPARy and RORa has been investigated in intraabdominal adipose tissue (IAT) samples. A direct correlation between the content of ABCA1 and ABCG1 proteins with RORa protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests the role of the transcription factor RORa in the regulation of IAT ABCA1 and ABCG1 protein levels. ABCA1 and ABCG1 gene expression positively correlated with obesity indicators such as body mass index (BMI) (r=0.522, p=0.004; r=0.594, p=0.001, respectively) and waist circumference (r=0.403, p=0.033; r=0.474, p=0.013, respectively). The development of obesity is associated with decreased IAT levels of RORa and LXRp mRNA (p=0.016 and p=0.002, respectively). These data suggest that the nuclear factor RORa can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1, while the level of IAT LXRp gene expression may be an important factor associated with the development of obesity.
@ARTICLE{Miroshnikova2016283,
author={Miroshnikova, V.V. and Panteleeva, A.A. and Bazhenova, E.A. and Demina, E.P. and Usenko, T.S. and Nikolaev, M.A. and Semenova, I.A. and Neimark, A.E. and He, J. and Belyaeva, O.D. and Berkovich, O.A. and Baranova, E.I. and Pchelina, S.N.},
title={Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue},
journal={Biomeditsinskaya Khimiya},
year={2016},
volume={62},
number={3},
pages={283-289},
doi={10.18097/PBMC20166203283},
note={cited By 2},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84997522653&doi=10.18097%2fPBMC20166203283&partnerID=40&md5=382b318bc8e14efb995e61db60f754e0},
affiliation={Konstantinov Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Orlova Roshcha, Gatchina, 188300, Russian Federation; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation},
abstract={Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis - LXRa, LXRp, PPARy and RORa has been investigated in intraabdominal adipose tissue (IAT) samples. A direct correlation between the content of ABCA1 and ABCG1 proteins with RORa protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests the role of the transcription factor RORa in the regulation of IAT ABCA1 and ABCG1 protein levels. ABCA1 and ABCG1 gene expression positively correlated with obesity indicators such as body mass index (BMI) (r=0.522, p=0.004; r=0.594, p=0.001, respectively) and waist circumference (r=0.403, p=0.033; r=0.474, p=0.013, respectively). The development of obesity is associated with decreased IAT levels of RORa and LXRp mRNA (p=0.016 and p=0.002, respectively). These data suggest that the nuclear factor RORa can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1, while the level of IAT LXRp gene expression may be an important factor associated with the development of obesity.},
author_keywords={ABCA1 and ABCG1 transporters;  Gene expression;  Intraabdominal adipose tissue;  Transcriptional regulators},
publisher={Russian Academy of Medical Sciences},
issn={23106905},
pubmed_id={27420620},
language={Russian},
abbrev_source_title={Biomeditsinskaya Khim.},
document_type={Article},
source={Scopus},
}
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