Regulation of ABCA1 and ABCG1 transporter gene expression in the intraabdominal adipose tissue. Miroshnikova, V., Panteleeva, A., Bazhenova, E., Demina, E., Usenko, T., Nikolaev, M., Semenova, I., Neimark, A., He, J., Belyaeva, O., Berkovich, O., Baranova, E., & Pchelina, S. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 10(4):327-334, Maik Nauka-Interperiodica Publishing, 2016. cited By 0
Regulation of ABCA1 and ABCG1 transporter gene expression in the intraabdominal adipose tissue [link]Paper  doi  abstract   bibtex   
Tissue specific expression of genes encoding the cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis (LXRα, LXRβ, PPARγ and RORα) has been investigated in intraabdominal adipose tissue (IAT) samples from obese patients and patients without overweight. A direct correlation between the content of ABCA1 and ABCG1 proteins and the RORα protein level (r = 0.480, p < 0.05; r = 0.435, p < 0.05, respectively) suggests involvement of the transcription factor RORα in the regulation of ABCA1 and ABCG1 protein levels in IAT. ABCA1 and ABCG1 gene expression positively correlated with such obesity indicators as body mass index (BMI) (r = 0.522, p = 0.004; r = 0.594, p = 0.001, respectively) and waist circumference (r = 0.403, p = 0.033; r = 0.474, p = 0.013, respectively). The development of obesity is also associated with decreased IAT levels of RORα and LXRβ mRNA (p = 0.016 and p = 0.002, respectively). This suggest that the nuclear factor RORα can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1 genes, while the level of IAT LXRβ gene expression may be an important factor associated with the development of obesity. © 2016, Pleiades Publishing, Ltd.
@ARTICLE{Miroshnikova2016327,
author={Miroshnikova, V.V. and Panteleeva, A.A. and Bazhenova, E.A. and Demina, E.P. and Usenko, T.S. and Nikolaev, M.A. and Semenova, I.A. and Neimark, A.E. and He, J. and Belyaeva, O.D. and Berkovich, O.A. and Baranova, E.I. and Pchelina, S.N.},
title={Regulation of ABCA1 and ABCG1 transporter gene expression in the intraabdominal adipose tissue},
journal={Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry},
year={2016},
volume={10},
number={4},
pages={327-334},
doi={10.1134/S199075081604003X},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996562226&doi=10.1134%2fS199075081604003X&partnerID=40&md5=6b3dd567ae39cc86ce7512870773bc56},
affiliation={Konstantinov Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute,” Orlova Roshcha, Gatchina, 188300, Russian Federation; Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation},
abstract={Tissue specific expression of genes encoding the cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis (LXRα, LXRβ, PPARγ and RORα) has been investigated in intraabdominal adipose tissue (IAT) samples from obese patients and patients without overweight. A direct correlation between the content of ABCA1 and ABCG1 proteins and the RORα protein level (r = 0.480, p < 0.05; r = 0.435, p < 0.05, respectively) suggests involvement of the transcription factor RORα in the regulation of ABCA1 and ABCG1 protein levels in IAT. ABCA1 and ABCG1 gene expression positively correlated with such obesity indicators as body mass index (BMI) (r = 0.522, p = 0.004; r = 0.594, p = 0.001, respectively) and waist circumference (r = 0.403, p = 0.033; r = 0.474, p = 0.013, respectively). The development of obesity is also associated with decreased IAT levels of RORα and LXRβ mRNA (p = 0.016 and p = 0.002, respectively). This suggest that the nuclear factor RORα can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1 genes, while the level of IAT LXRβ gene expression may be an important factor associated with the development of obesity. © 2016, Pleiades Publishing, Ltd.},
author_keywords={ABCA1 and ABCG1 transporters;  gene expression;  intraabdominal adipose tissue;  transcriptional regulators},
correspondence_address1={Miroshnikova, V.V.; Konstantinov Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute,” Orlova RoshchaRussian Federation; email: mutantropol@mail.ru},
publisher={Maik Nauka-Interperiodica Publishing},
issn={19907508},
language={English},
abbrev_source_title={Biochem. (Moscow) Suppl. Ser. B Biomed. Chem.},
document_type={Article},
source={Scopus},
}
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