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@article{
 title = {Potential crosstalk between cofilin-1 and EGFR pathways in cisplatin resistance of non-small-cell lung cancer},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {2014,2015,accepted,chemotherapy resistance,cofilin-1,december 02,egfr,february 28,january 22,nsclc,personalized medicine,published,received},
 pages = {3531-9},
 volume = {6},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/25784483%5Cnhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4414134},
 publisher = {Impact Journals, LLC},
 id = {3dfa69f9-a850-362a-832c-3c71ca53af81},
 created = {2019-02-04T15:29:32.786Z},
 file_attached = {false},
 profile_id = {81a97cb0-31b8-3385-bd0e-efcfffedaada},
 group_id = {b954b4a7-36ce-39f9-9501-2e3795a979e9},
 last_modified = {2019-02-04T15:29:32.786Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Muller2015},
 source_type = {Article},
 private_publication = {false},
 abstract = {Current challenge in oncology is to establish the concept of personalized medicine in clinical practice. In this context, non-small-cell lung cancer (NSCLC) presents clinical, histological and molecular heterogeneity, being one of the most genomically diverse of all cancers. Recent advances added Epidermal Growth Factor Receptor (EGFR) as a predictive biomarker for patients with advanced NSCLC. In tumors with activating EGFR mutations, tyrosine kinase inhibitors (TKI) are indicated as first-line treatment, although restricted to a very small target population. In this context, cofilin-1 (a cytosolic protein involved with actin dynamics) has been widely studied as a biomarker of an aggressive phenotype in tumors, and overexpression of cofilin-1 is associated with cisplatin resistance and poor prognosis in NSCLC. Here, we gather information about the predictive potential of cofilin-1 and reviewed the crosstalk between cofilin-1/EGFR pathways. We aimed to highlight new perspectives of how these interactions might affect cisplatin resistance in NSCLC. We propose that cofilin-1 quantification in clinical samples in combination with presence/absence of EGFR mutation could be used to select patients that would benefit from TKI's treatment. This information is of paramount importance and could result in a possibility of guiding more effective treatments to NSCLC patients.},
 bibtype = {article},
 author = {Müller, Carolina Beatriz and De Bastiani, Marco Antônio and Becker, Matheus and França, Fernanda Stapenhorst and Branco, Mariane Araujo and Castro, Mauro Antônio Alves and Klamt, Fabio},
 journal = {Oncotarget},
 number = {6}
}