@article{moller_allelic_2007,
	title = {Allelic variation in {BTNL2} and susceptibility to tuberculosis in a {South} {African} population},
	volume = {9},
	issn = {1286-4579},
	doi = {10.1016/j.micinf.2007.01.011},
	abstract = {Tuberculosis and sarcoidosis show phenotypic features of granulomatous disease. The bacterium Mycobacterium tuberculosis can induce the expression of the sarcoidosis susceptibility gene BTNL2 in monocyte-derived macrophages. BTNL2 was therefore investigated as a candidate gene for tuberculosis in a case-control association study in the South African Coloured population. We sequenced the coding regions of BTNL2 to detect known and novel polymorphisms and genotyped 18 SNPs in 432 pulmonary tuberculosis cases and 482 controls. We did not find a significant association between the truncating rs2076530 SNP, previously associated with sarcoidosis, and tuberculosis. No association was found between any of the other SNPs studied and disease and none of the estimated haplotypes showed any association with TB. Comparative analyses with the South African data from this study and published data on German and American populations revealed that, for a segment of BTNL2, the admixed, but not stratified, South African population resembles the African-Americans more than white populations.},
	language = {eng},
	number = {4},
	journal = {Microbes and Infection / Institut Pasteur},
	author = {Möller, Marlo and Kwiatkowski, Ruta and Nebel, Almut and van Helden, Paul D. and Hoal, Eileen G. and Schreiber, Stefan},
	month = apr,
	year = {2007},
	pmid = {17347014},
	note = {00015 },
	keywords = {Adolescent, Adult, Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Linkage Disequilibrium, Male, Membrane Glycoproteins, Middle Aged, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Sarcoidosis, South Africa, Tuberculosis},
	pages = {522--528},
}

{"_id":"yzaFBrWmK2o5aXj33","bibbaseid":"mller-kwiatkowski-nebel-vanhelden-hoal-schreiber-allelicvariationinbtnl2andsusceptibilitytotuberculosisinasouthafricanpopulation-2007","author_short":["Möller, M.","Kwiatkowski, R.","Nebel, A.","van Helden, P. D.","Hoal, E. G.","Schreiber, S."],"bibdata":{"bibtype":"article","type":"article","title":"Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population","volume":"9","issn":"1286-4579","doi":"10.1016/j.micinf.2007.01.011","abstract":"Tuberculosis and sarcoidosis show phenotypic features of granulomatous disease. The bacterium Mycobacterium tuberculosis can induce the expression of the sarcoidosis susceptibility gene BTNL2 in monocyte-derived macrophages. BTNL2 was therefore investigated as a candidate gene for tuberculosis in a case-control association study in the South African Coloured population. We sequenced the coding regions of BTNL2 to detect known and novel polymorphisms and genotyped 18 SNPs in 432 pulmonary tuberculosis cases and 482 controls. We did not find a significant association between the truncating rs2076530 SNP, previously associated with sarcoidosis, and tuberculosis. No association was found between any of the other SNPs studied and disease and none of the estimated haplotypes showed any association with TB. Comparative analyses with the South African data from this study and published data on German and American populations revealed that, for a segment of BTNL2, the admixed, but not stratified, South African population resembles the African-Americans more than white populations.","language":"eng","number":"4","journal":"Microbes and Infection / Institut Pasteur","author":[{"propositions":[],"lastnames":["Möller"],"firstnames":["Marlo"],"suffixes":[]},{"propositions":[],"lastnames":["Kwiatkowski"],"firstnames":["Ruta"],"suffixes":[]},{"propositions":[],"lastnames":["Nebel"],"firstnames":["Almut"],"suffixes":[]},{"propositions":["van"],"lastnames":["Helden"],"firstnames":["Paul","D."],"suffixes":[]},{"propositions":[],"lastnames":["Hoal"],"firstnames":["Eileen","G."],"suffixes":[]},{"propositions":[],"lastnames":["Schreiber"],"firstnames":["Stefan"],"suffixes":[]}],"month":"April","year":"2007","pmid":"17347014","note":"00015 ","keywords":"Adolescent, Adult, Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Linkage Disequilibrium, Male, Membrane Glycoproteins, Middle Aged, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Sarcoidosis, South Africa, Tuberculosis","pages":"522–528","bibtex":"@article{moller_allelic_2007,\n\ttitle = {Allelic variation in {BTNL2} and susceptibility to tuberculosis in a {South} {African} population},\n\tvolume = {9},\n\tissn = {1286-4579},\n\tdoi = {10.1016/j.micinf.2007.01.011},\n\tabstract = {Tuberculosis and sarcoidosis show phenotypic features of granulomatous disease. The bacterium Mycobacterium tuberculosis can induce the expression of the sarcoidosis susceptibility gene BTNL2 in monocyte-derived macrophages. BTNL2 was therefore investigated as a candidate gene for tuberculosis in a case-control association study in the South African Coloured population. We sequenced the coding regions of BTNL2 to detect known and novel polymorphisms and genotyped 18 SNPs in 432 pulmonary tuberculosis cases and 482 controls. We did not find a significant association between the truncating rs2076530 SNP, previously associated with sarcoidosis, and tuberculosis. No association was found between any of the other SNPs studied and disease and none of the estimated haplotypes showed any association with TB. Comparative analyses with the South African data from this study and published data on German and American populations revealed that, for a segment of BTNL2, the admixed, but not stratified, South African population resembles the African-Americans more than white populations.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Microbes and Infection / Institut Pasteur},\n\tauthor = {Möller, Marlo and Kwiatkowski, Ruta and Nebel, Almut and van Helden, Paul D. and Hoal, Eileen G. and Schreiber, Stefan},\n\tmonth = apr,\n\tyear = {2007},\n\tpmid = {17347014},\n\tnote = {00015 },\n\tkeywords = {Adolescent, Adult, Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Linkage Disequilibrium, Male, Membrane Glycoproteins, Middle Aged, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Sarcoidosis, South Africa, Tuberculosis},\n\tpages = {522--528},\n}\n\n\n\n","author_short":["Möller, M.","Kwiatkowski, R.","Nebel, A.","van Helden, P. D.","Hoal, E. G.","Schreiber, S."],"key":"moller_allelic_2007","id":"moller_allelic_2007","bibbaseid":"mller-kwiatkowski-nebel-vanhelden-hoal-schreiber-allelicvariationinbtnl2andsusceptibilitytotuberculosisinasouthafricanpopulation-2007","role":"author","urls":{},"keyword":["Adolescent","Adult","Alleles","Case-Control Studies","Female","Genetic Predisposition to Disease","Genetic Variation","Humans","Linkage Disequilibrium","Male","Membrane Glycoproteins","Middle Aged","Mycobacterium tuberculosis","Polymorphism","Single Nucleotide","Sarcoidosis","South Africa","Tuberculosis"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/TBHostGen","dataSources":["csPxbBZ9RG8CqYnrf"],"keywords":["adolescent","adult","alleles","case-control studies","female","genetic predisposition to disease","genetic variation","humans","linkage disequilibrium","male","membrane glycoproteins","middle aged","mycobacterium tuberculosis","polymorphism","single nucleotide","sarcoidosis","south africa","tuberculosis"],"search_terms":["allelic","variation","btnl2","susceptibility","tuberculosis","south","african","population","möller","kwiatkowski","nebel","van helden","hoal","schreiber"],"title":"Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population","year":2007}