@article{muller_comparative_2012,
	title = {Comparative analysis of a putative tuberculosis-susceptibility gene, {MC3R}, and pseudogene sequences in cattle, {African} buffalo, hyena, rhinoceros and other {African} bovids and ruminants},
	volume = {136},
	issn = {1424-859X},
	doi = {10.1159/000335464},
	abstract = {Studies in humans have suggested the possible involvement of melanocortin-3-receptor (MC3R) and other components of the central melanocortin system in host defense against mycobacteria. We report a genomic DNA nucleotide sequence highly homologous to human MC3R in several bovids and non-bovid African wildlife species. Nucleotide sequence analysis indicates that the orthologous genes of cattle and buffalo are highly homologous (89.4 and 90\%, respectively) to the human MC3R gene. Sequence results also identified a typical non-functional, duplicated pseudogene, MC3RP, in 7 species from the family Bovidae. No pseudogene was found in animals outside Bovidae. The presence of the pseudogene in tuberculosis-susceptible species could have possible immunomodulatory effects on susceptibility to bovine tuberculosis infection, as well as a considerable influence on energy metabolism and food conversion efficiency.},
	language = {eng},
	number = {2},
	journal = {Cytogenetic and Genome Research},
	author = {Müller, A. and Möller, M. and Adams, L. A. and Warren, R. M. and Hoal, E. G. and van Helden, P. D.},
	year = {2012},
	pmid = {22286663},
	note = {00001 },
	keywords = {Amino Acid Sequence, Animals, Base Sequence, Buffaloes, Cattle, Genetic Predisposition to Disease, Humans, Hyaenidae, Molecular Sequence Data, Perissodactyla, Phylogeny, Pseudogenes, Receptor, Melanocortin, Type 3, Ruminants, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity, Tuberculosis, Tuberculosis, Bovine},
	pages = {117--122},
}

{"_id":"a2Q8mm29C7rqP5LqA","bibbaseid":"mller-mller-adams-warren-hoal-vanhelden-comparativeanalysisofaputativetuberculosissusceptibilitygenemc3randpseudogenesequencesincattleafricanbuffalohyenarhinocerosandotherafricanbovidsandruminants-2012","author_short":["Müller, A.","Möller, M.","Adams, L. A.","Warren, R. M.","Hoal, E. G.","van Helden, P. D."],"bibdata":{"bibtype":"article","type":"article","title":"Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants","volume":"136","issn":"1424-859X","doi":"10.1159/000335464","abstract":"Studies in humans have suggested the possible involvement of melanocortin-3-receptor (MC3R) and other components of the central melanocortin system in host defense against mycobacteria. We report a genomic DNA nucleotide sequence highly homologous to human MC3R in several bovids and non-bovid African wildlife species. Nucleotide sequence analysis indicates that the orthologous genes of cattle and buffalo are highly homologous (89.4 and 90%, respectively) to the human MC3R gene. Sequence results also identified a typical non-functional, duplicated pseudogene, MC3RP, in 7 species from the family Bovidae. No pseudogene was found in animals outside Bovidae. The presence of the pseudogene in tuberculosis-susceptible species could have possible immunomodulatory effects on susceptibility to bovine tuberculosis infection, as well as a considerable influence on energy metabolism and food conversion efficiency.","language":"eng","number":"2","journal":"Cytogenetic and Genome Research","author":[{"propositions":[],"lastnames":["Müller"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Möller"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Adams"],"firstnames":["L.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Warren"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Hoal"],"firstnames":["E.","G."],"suffixes":[]},{"propositions":["van"],"lastnames":["Helden"],"firstnames":["P.","D."],"suffixes":[]}],"year":"2012","pmid":"22286663","note":"00001 ","keywords":"Amino Acid Sequence, Animals, Base Sequence, Buffaloes, Cattle, Genetic Predisposition to Disease, Humans, Hyaenidae, Molecular Sequence Data, Perissodactyla, Phylogeny, Pseudogenes, Receptor, Melanocortin, Type 3, Ruminants, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity, Tuberculosis, Tuberculosis, Bovine","pages":"117–122","bibtex":"@article{muller_comparative_2012,\n\ttitle = {Comparative analysis of a putative tuberculosis-susceptibility gene, {MC3R}, and pseudogene sequences in cattle, {African} buffalo, hyena, rhinoceros and other {African} bovids and ruminants},\n\tvolume = {136},\n\tissn = {1424-859X},\n\tdoi = {10.1159/000335464},\n\tabstract = {Studies in humans have suggested the possible involvement of melanocortin-3-receptor (MC3R) and other components of the central melanocortin system in host defense against mycobacteria. We report a genomic DNA nucleotide sequence highly homologous to human MC3R in several bovids and non-bovid African wildlife species. Nucleotide sequence analysis indicates that the orthologous genes of cattle and buffalo are highly homologous (89.4 and 90\\%, respectively) to the human MC3R gene. Sequence results also identified a typical non-functional, duplicated pseudogene, MC3RP, in 7 species from the family Bovidae. No pseudogene was found in animals outside Bovidae. The presence of the pseudogene in tuberculosis-susceptible species could have possible immunomodulatory effects on susceptibility to bovine tuberculosis infection, as well as a considerable influence on energy metabolism and food conversion efficiency.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Cytogenetic and Genome Research},\n\tauthor = {Müller, A. and Möller, M. and Adams, L. A. and Warren, R. M. and Hoal, E. G. and van Helden, P. 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D."],"key":"muller_comparative_2012","id":"muller_comparative_2012","bibbaseid":"mller-mller-adams-warren-hoal-vanhelden-comparativeanalysisofaputativetuberculosissusceptibilitygenemc3randpseudogenesequencesincattleafricanbuffalohyenarhinocerosandotherafricanbovidsandruminants-2012","role":"author","urls":{},"keyword":["Amino Acid Sequence","Animals","Base Sequence","Buffaloes","Cattle","Genetic Predisposition to Disease","Humans","Hyaenidae","Molecular Sequence Data","Perissodactyla","Phylogeny","Pseudogenes","Receptor","Melanocortin","Type 3","Ruminants","Sequence Analysis","DNA","Sequence Homology","Amino Acid","Species Specificity","Tuberculosis","Tuberculosis","Bovine"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/TBHostGen","dataSources":["csPxbBZ9RG8CqYnrf"],"keywords":["amino acid sequence","animals","base sequence","buffaloes","cattle","genetic predisposition to disease","humans","hyaenidae","molecular sequence data","perissodactyla","phylogeny","pseudogenes","receptor","melanocortin","type 3","ruminants","sequence analysis","dna","sequence homology","amino acid","species specificity","tuberculosis","tuberculosis","bovine"],"search_terms":["comparative","analysis","putative","tuberculosis","susceptibility","gene","mc3r","pseudogene","sequences","cattle","african","buffalo","hyena","rhinoceros","african","bovids","ruminants","müller","möller","adams","warren","hoal","van helden"],"title":"Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants","year":2012}