microRNAs: Small molecules with a large impact on colorectal cancer. Moazzendizaji, S., Sevbitov, A., Ezzatifar, F., Jalili, H. R., Aalii, M., Hemmatzadeh, M., Aslani, S., Gholizadeh Navashenaq, J., Safari, R., Hosseinzadeh, R., Rahmany, M. R., & Mohammadi, H. Biotechnology and Applied Biochemistry, September, 2021. doi abstract bibtex Colorectal cancer (CRC) accounts for one of the main cancer-related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that aberrant transcription of microRNAs (miRNAs), a class of small, noncoding RNA molecules, has a significant role in the inception and promotion of CRC. In the involved tissues of CRC, the transcription profile of miRNAs is modulated, and their expression templates are related with prognosis, diagnosis, and treatment outcomes. Here, in the current review, we attempted to discuss the latest information regarding the aberrantly expressed miRNAs in CRC and the advantages of utilizing miRNAs as biomarkers for early diagnosis and prognosis of CRC as well as potential therapeutic application. The effect of miRNAs involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-β pathways, was clarified.
@article{moazzendizaji_micrornas_2021,
title = {{microRNAs}: {Small} molecules with a large impact on colorectal cancer},
issn = {1470-8744},
shorttitle = {{microRNAs}},
doi = {10.1002/bab.2255},
abstract = {Colorectal cancer (CRC) accounts for one of the main cancer-related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that aberrant transcription of microRNAs (miRNAs), a class of small, noncoding RNA molecules, has a significant role in the inception and promotion of CRC. In the involved tissues of CRC, the transcription profile of miRNAs is modulated, and their expression templates are related with prognosis, diagnosis, and treatment outcomes. Here, in the current review, we attempted to discuss the latest information regarding the aberrantly expressed miRNAs in CRC and the advantages of utilizing miRNAs as biomarkers for early diagnosis and prognosis of CRC as well as potential therapeutic application. The effect of miRNAs involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-β pathways, was clarified.},
language = {eng},
journal = {Biotechnology and Applied Biochemistry},
author = {Moazzendizaji, Sahand and Sevbitov, Andrey and Ezzatifar, Fatemeh and Jalili, Hamid Reza and Aalii, Morteza and Hemmatzadeh, Maryam and Aslani, Saeed and Gholizadeh Navashenaq, Jamshid and Safari, Roghaiyeh and Hosseinzadeh, Ramin and Rahmany, Mohammad Reza and Mohammadi, Hamed},
month = sep,
year = {2021},
pmid = {34550619},
keywords = {colorectal cancer, microRNAs, signaling pathways},
}
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