Questions in Mild Asthma: An Official American Thoracic Society Research Statement. Mohan, A., Lugogo, N. L., Hanania, N. A., Reddel, H. K., Akuthota, P., O'Byrne, P. M., Guilbert, T., Papi, A., Price, D., Jenkins, C. R., Kraft, M., Bacharier, L. B., Boulet, L., Yawn, B. P., Pleasants, R., Lazarus, S. C., Beasley, R., Gauvreau, G., Israel, E., Schneider-Futschik, E. K., Yorgancioglu, A., Martinez, F., Moore, W., & Sumino, K. American Journal of Respiratory and Critical Care Medicine, 207(11):e77–e96, June, 2023.
doi  abstract   bibtex   
Background: Patients with mild asthma are believed to represent the majority of patients with asthma. Disease-associated risks such as exacerbations, lung function decline, and death have been understudied in this patient population. There have been no prior efforts from major societies to describe research needs in mild asthma. Methods: A multidisciplinary, diverse group of 24 international experts reviewed the literature, identified knowledge gaps, and provided research recommendations relating to mild asthma definition, pathophysiology, and management across all age groups. Research needs were also investigated from a patient perspective, generated in conjunction with patients with asthma, caregivers, and stakeholders. Of note, this project is not a systematic review of the evidence and is not a clinical practice guideline. Results: There are multiple unmet needs in research on mild asthma driven by large knowledge gaps in all areas. Specifically, there is an immediate need for a robust mild asthma definition and an improved understanding of its pathophysiology and management strategies across all age groups. Future research must factor in patient perspectives. Conclusions: Despite significant advances in severe asthma, there remain innumerable research areas requiring urgent attention in mild asthma. An important first step is to determine a better definition that will accurately reflect the heterogeneity and risks noted in this group. This research statement highlights the topics of research that are of the highest priority. Furthermore, it firmly advocates the need for engagement with patient groups and for more support for research in this field.
@article{mohan_questions_2023,
	title = {Questions in {Mild} {Asthma}: {An} {Official} {American} {Thoracic} {Society} {Research} {Statement}},
	volume = {207},
	issn = {1535-4970},
	shorttitle = {Questions in {Mild} {Asthma}},
	doi = {10.1164/rccm.202304-0642ST},
	abstract = {Background: Patients with mild asthma are believed to represent the majority of patients with asthma. Disease-associated risks such as exacerbations, lung function decline, and death have been understudied in this patient population. There have been no prior efforts from major societies to describe research needs in mild asthma. Methods: A multidisciplinary, diverse group of 24 international experts reviewed the literature, identified knowledge gaps, and provided research recommendations relating to mild asthma definition, pathophysiology, and management across all age groups. Research needs were also investigated from a patient perspective, generated in conjunction with patients with asthma, caregivers, and stakeholders. Of note, this project is not a systematic review of the evidence and is not a clinical practice guideline. Results: There are multiple unmet needs in research on mild asthma driven by large knowledge gaps in all areas. Specifically, there is an immediate need for a robust mild asthma definition and an improved understanding of its pathophysiology and management strategies across all age groups. Future research must factor in patient perspectives. Conclusions: Despite significant advances in severe asthma, there remain innumerable research areas requiring urgent attention in mild asthma. An important first step is to determine a better definition that will accurately reflect the heterogeneity and risks noted in this group. This research statement highlights the topics of research that are of the highest priority. Furthermore, it firmly advocates the need for engagement with patient groups and for more support for research in this field.},
	language = {eng},
	number = {11},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Mohan, Arjun and Lugogo, Njira L. and Hanania, Nicola A. and Reddel, Helen K. and Akuthota, Praveen and O'Byrne, Paul M. and Guilbert, Theresa and Papi, Alberto and Price, David and Jenkins, Christine R. and Kraft, Monica and Bacharier, Leonard B. and Boulet, Louis-Phillippe and Yawn, Barbara P. and Pleasants, Roy and Lazarus, Stephen C. and Beasley, Richard and Gauvreau, Gail and Israel, Elliot and Schneider-Futschik, Elena K. and Yorgancioglu, Arzu and Martinez, Fernando and Moore, Wendy and Sumino, Kaharu},
	month = jun,
	year = {2023},
	pmid = {37260227},
	pmcid = {PMC10263130},
	keywords = {Asthma, Caregivers, Humans, Societies, Medical, United States, definition, management, mild asthma, pathophysiology, research needs},
	pages = {e77--e96},
}
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