@Article{Moiseeva2023,
  author          = {Moiseeva, A. N. and Makoveeva, K. A. and Furkina, E. B. and Artyushova, E. V. and German, M. N. and Khomenko, I. A. and Konevega, A. L. and Kormazeva, E. S. and Novikov, V. I. and Aksenov, N. V. and Gustova, N. S. and Aliev, R. A.},
  journal         = {Nuclear medicine and biology},
  title           = {Co-production of (155)Tb and (152)Tb irradiating (155)Gd / (151)Eu tandem target with a medium energy α-particle beam.},
  year            = {2023},
  issn            = {1872-9614},
  pages           = {108389},
  volume          = {126-127},
  abstract        = {Four terbium isotopes (149,152,155,161)Tb emitting various types of radiation can be used for both diagnostics and therapy. (152)Tb emits positrons and is ideal for PET. (155)Tb is considered a promising Auger emitter and a diagnostic pair for other terbium therapeutic isotopes. Several methods for the production of (155)Tb using charged particle accelerators have been proposed, but they all have significant limitations. The restricted availability of this isotope hinders its medical applications. We have proposed a new method for production of (155)Tb, irradiating enriched (155)Gd by alpha particles. The possibility of simultaneous production of two isotopes of terbium, (152,155)Tb, was also studied for more efficient cyclotron beam use. Irradiation of (155)Gd enriched targets and (155)Gd /  (151)Eu tandem target with alpha-particles with an energy of 54 MeV was carried out at the U-150 cyclotron at the NRC "Kurchatov Institute". The cross sections of nuclear reactions on (enr-155)Gd were measured by the stack foil technique, detecting the gamma-radiation of the activation products. The separation of rare earth elements was performed by extraction chromatography with the LN Resin. (155)Tb was produced via (155)Dy decay. The cross sections for the (155,156)Tb and (155,157)Dy production were measured by the irradiation of a gadolinium target enriched with the (155)Gd isotope with alpha-particles in an energy range of 54 → 33 MeV. The yield of (155)Dy on a thick target at 54 MeV was 130 MBq/μAh, which makes it possible to obtain 1 GBq of (155)Tb in 11 hour-irradiation with 20 μA beam current. The possibility of simultaneous production of (152,155)Tb by irradiation of (155)Gd and (151)Eu tandem target with medium-energy alpha-particles is implemented. Optimal irradiation energy ranges of alpha -particles as 54 → 42 MeV for (155)Tb and 42 → 34 MeV for (152)Tb were suggested. Product activity and radionuclidic purity were calculated.},
  chemicals       = {Terbium, Radioisotopes},
  citation-subset = {IM},
  completed       = {2023-12-16},
  country         = {United States},
  doi             = {10.1016/j.nucmedbio.2023.108389},
  issn-linking    = {0969-8051},
  keywords        = {Terbium, chemistry; Alpha Particles, therapeutic use; Radioisotopes, chemistry; Electrons; Cross section; Cyclotron; Nuclear reaction; Tandem target; Terbium-152; Terbium-155},
  nlm-id          = {9304420},
  owner           = {NLM},
  pii             = {S0969-8051(23)00077-X},
  pmid            = {37783103},
  pubmodel        = {Print-Electronic},
  pubstate        = {ppublish},
  revised         = {2023-12-16},
  season          = {Nov-Dec},
}

{"_id":"rqg8uZoNaXiNfJF8v","bibbaseid":"moiseeva-makoveeva-furkina-artyushova-german-khomenko-konevega-kormazeva-etal-coproductionof155tband152tbirradiating155gd151eutandemtargetwithamediumenergyparticlebeam-2023","author_short":["Moiseeva, A. N.","Makoveeva, K. A.","Furkina, E. B.","Artyushova, E. V.","German, M. N.","Khomenko, I. A.","Konevega, A. L.","Kormazeva, E. S.","Novikov, V. I.","Aksenov, N. V.","Gustova, N. S.","Aliev, R. A."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Moiseeva"],"firstnames":["A.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Makoveeva"],"firstnames":["K.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Furkina"],"firstnames":["E.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Artyushova"],"firstnames":["E.","V."],"suffixes":[]},{"propositions":[],"lastnames":["German"],"firstnames":["M.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Khomenko"],"firstnames":["I.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Konevega"],"firstnames":["A.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Kormazeva"],"firstnames":["E.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Novikov"],"firstnames":["V.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Aksenov"],"firstnames":["N.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Gustova"],"firstnames":["N.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aliev"],"firstnames":["R.","A."],"suffixes":[]}],"journal":"Nuclear medicine and biology","title":"Co-production of (155)Tb and (152)Tb irradiating (155)Gd / (151)Eu tandem target with a medium energy α-particle beam.","year":"2023","issn":"1872-9614","pages":"108389","volume":"126-127","abstract":"Four terbium isotopes (149,152,155,161)Tb emitting various types of radiation can be used for both diagnostics and therapy. (152)Tb emits positrons and is ideal for PET. (155)Tb is considered a promising Auger emitter and a diagnostic pair for other terbium therapeutic isotopes. Several methods for the production of (155)Tb using charged particle accelerators have been proposed, but they all have significant limitations. The restricted availability of this isotope hinders its medical applications. We have proposed a new method for production of (155)Tb, irradiating enriched (155)Gd by alpha particles. The possibility of simultaneous production of two isotopes of terbium, (152,155)Tb, was also studied for more efficient cyclotron beam use. Irradiation of (155)Gd enriched targets and (155)Gd /  (151)Eu tandem target with alpha-particles with an energy of 54 MeV was carried out at the U-150 cyclotron at the NRC \"Kurchatov Institute\". The cross sections of nuclear reactions on (enr-155)Gd were measured by the stack foil technique, detecting the gamma-radiation of the activation products. The separation of rare earth elements was performed by extraction chromatography with the LN Resin. (155)Tb was produced via (155)Dy decay. The cross sections for the (155,156)Tb and (155,157)Dy production were measured by the irradiation of a gadolinium target enriched with the (155)Gd isotope with alpha-particles in an energy range of 54 → 33 MeV. The yield of (155)Dy on a thick target at 54 MeV was 130 MBq/μAh, which makes it possible to obtain 1 GBq of (155)Tb in 11 hour-irradiation with 20 μA beam current. The possibility of simultaneous production of (152,155)Tb by irradiation of (155)Gd and (151)Eu tandem target with medium-energy alpha-particles is implemented. Optimal irradiation energy ranges of alpha -particles as 54 → 42 MeV for (155)Tb and 42 → 34 MeV for (152)Tb were suggested. Product activity and radionuclidic purity were calculated.","chemicals":"Terbium, Radioisotopes","citation-subset":"IM","completed":"2023-12-16","country":"United States","doi":"10.1016/j.nucmedbio.2023.108389","issn-linking":"0969-8051","keywords":"Terbium, chemistry; Alpha Particles, therapeutic use; Radioisotopes, chemistry; Electrons; Cross section; Cyclotron; Nuclear reaction; Tandem target; Terbium-152; Terbium-155","nlm-id":"9304420","owner":"NLM","pii":"S0969-8051(23)00077-X","pmid":"37783103","pubmodel":"Print-Electronic","pubstate":"ppublish","revised":"2023-12-16","season":"Nov-Dec","bibtex":"@Article{Moiseeva2023,\n author = {Moiseeva, A. N. and Makoveeva, K. A. and Furkina, E. B. and Artyushova, E. V. and German, M. N. and Khomenko, I. A. and Konevega, A. L. and Kormazeva, E. S. and Novikov, V. I. and Aksenov, N. V. and Gustova, N. S. and Aliev, R. A.},\n journal = {Nuclear medicine and biology},\n title = {Co-production of (155)Tb and (152)Tb irradiating (155)Gd / (151)Eu tandem target with a medium energy α-particle beam.},\n year = {2023},\n issn = {1872-9614},\n pages = {108389},\n volume = {126-127},\n abstract = {Four terbium isotopes (149,152,155,161)Tb emitting various types of radiation can be used for both diagnostics and therapy. (152)Tb emits positrons and is ideal for PET. (155)Tb is considered a promising Auger emitter and a diagnostic pair for other terbium therapeutic isotopes. Several methods for the production of (155)Tb using charged particle accelerators have been proposed, but they all have significant limitations. The restricted availability of this isotope hinders its medical applications. We have proposed a new method for production of (155)Tb, irradiating enriched (155)Gd by alpha particles. The possibility of simultaneous production of two isotopes of terbium, (152,155)Tb, was also studied for more efficient cyclotron beam use. Irradiation of (155)Gd enriched targets and (155)Gd /  (151)Eu tandem target with alpha-particles with an energy of 54 MeV was carried out at the U-150 cyclotron at the NRC \"Kurchatov Institute\". The cross sections of nuclear reactions on (enr-155)Gd were measured by the stack foil technique, detecting the gamma-radiation of the activation products. The separation of rare earth elements was performed by extraction chromatography with the LN Resin. (155)Tb was produced via (155)Dy decay. The cross sections for the (155,156)Tb and (155,157)Dy production were measured by the irradiation of a gadolinium target enriched with the (155)Gd isotope with alpha-particles in an energy range of 54 → 33 MeV. The yield of (155)Dy on a thick target at 54 MeV was 130 MBq/μAh, which makes it possible to obtain 1 GBq of (155)Tb in 11 hour-irradiation with 20 μA beam current. The possibility of simultaneous production of (152,155)Tb by irradiation of (155)Gd and (151)Eu tandem target with medium-energy alpha-particles is implemented. Optimal irradiation energy ranges of alpha -particles as 54 → 42 MeV for (155)Tb and 42 → 34 MeV for (152)Tb were suggested. Product activity and radionuclidic purity were calculated.},\n chemicals = {Terbium, Radioisotopes},\n citation-subset = {IM},\n completed = {2023-12-16},\n country = {United States},\n doi = {10.1016/j.nucmedbio.2023.108389},\n issn-linking = {0969-8051},\n keywords = {Terbium, chemistry; Alpha Particles, therapeutic use; Radioisotopes, chemistry; Electrons; Cross section; Cyclotron; Nuclear reaction; Tandem target; Terbium-152; Terbium-155},\n nlm-id = {9304420},\n owner = {NLM},\n pii = {S0969-8051(23)00077-X},\n pmid = {37783103},\n pubmodel = {Print-Electronic},\n pubstate = {ppublish},\n revised = {2023-12-16},\n season = {Nov-Dec},\n}\n\n","author_short":["Moiseeva, A. N.","Makoveeva, K. A.","Furkina, E. B.","Artyushova, E. V.","German, M. N.","Khomenko, I. A.","Konevega, A. L.","Kormazeva, E. S.","Novikov, V. I.","Aksenov, N. V.","Gustova, N. S.","Aliev, R. A."],"key":"Moiseeva2023","id":"Moiseeva2023","bibbaseid":"moiseeva-makoveeva-furkina-artyushova-german-khomenko-konevega-kormazeva-etal-coproductionof155tband152tbirradiating155gd151eutandemtargetwithamediumenergyparticlebeam-2023","role":"author","urls":{},"keyword":["Terbium","chemistry; Alpha Particles","therapeutic use; Radioisotopes","chemistry; Electrons; Cross section; Cyclotron; Nuclear reaction; Tandem target; Terbium-152; Terbium-155"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bio.pnpi.nrcki.ru/wp-content/uploads/2024/02/lmbni_2023.txt","dataSources":["x6wsWRRxTjczPPh9A"],"keywords":["terbium","chemistry; alpha particles","therapeutic use; radioisotopes","chemistry; electrons; cross section; cyclotron; nuclear reaction; tandem target; terbium-152; terbium-155"],"search_terms":["production","155","152","irradiating","155","151","tandem","target","medium","energy","particle","beam","moiseeva","makoveeva","furkina","artyushova","german","khomenko","konevega","kormazeva","novikov","aksenov","gustova","aliev"],"title":"Co-production of (155)Tb and (152)Tb irradiating (155)Gd / (151)Eu tandem target with a medium energy α-particle beam.","year":2023}