@article{molteni_differential_2002,
	title = {Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray.},
	volume = {16},
	issn = {0953-816X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/12383240},
	abstract = {Studies were performed to determine the effects of acute and chronic voluntary periods of exercise on the expression of hippocampal genes. RNAs from rodents exposed to a running wheel for 3, 7 and 28 days were examined using a microarray with 1176 cDNAs expressed primarily in the brain. The expression of selected genes was quantified by Taqman RT-PCR or RNase protection assay. The largest up-regulation was observed in genes involved with synaptic trafficking (synapsin I, synaptotagmin and syntaxin); signal transduction pathways (Ca2+/calmodulin-dependent protein kinase II, CaM-KII; mitogen-activated/extracellular signal-regulated protein kinase, MAP-K/ERK I and II; protein kinase C, PKC-delta) or transcription regulators (cyclic AMP response element binding protein, CREB). Genes associated with the glutamatergic system were up-regulated (N-methyl-d-aspartate receptor, NMDAR-2A and NMDAR-2B and excitatory amino acid carrier 1, EAAC1), while genes related to the gamma-aminobutyric acid (GABA) system were down-regulated (GABAA receptor, glutamate decarboxylase GAD65). Brain-derived neurotrophic factor (BDNF) was the only trophic factor whose gene was consistently up-regulated at all timepoints. These results, together with the fact that most of the genes up-regulated have a recognized interaction with BDNF, suggest a central role for BDNF on the effects of exercise on brain plasticity. The temporal profile of gene expression seems to delineate a mechanism by which specific molecular pathways are activated after exercise performance. For example, the CaM-K signal system seems to be active during acute and chronic periods of exercise, while the MAP-K/ERK system seems more important during long-term exercise.},
	number = {6},
	urldate = {2014-02-03},
	journal = {The European journal of neuroscience},
	author = {Molteni, Raffaella and Ying, Zhe and Gómez-Pinilla, Fernando},
	month = sep,
	year = {2002},
	pmid = {12383240},
	keywords = {Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: biosynthesis, Brain-Derived Neurotrophic Factor: genetics, DNA, Complementary, DNA, Complementary: analysis, DNA, Complementary: genetics, Gene Expression Regulation, Gene Expression Regulation: genetics, Genes, Regulator, Genes, Regulator: genetics, Hippocampus, Hippocampus: metabolism, MAP Kinase Signaling System, MAP Kinase Signaling System: genetics, Male, Nerve Growth Factors, Nerve Growth Factors: biosynthesis, Nerve Growth Factors: genetics, Nerve Tissue Proteins, Nerve Tissue Proteins: biosynthesis, Nerve Tissue Proteins: genetics, Neuronal Plasticity, Neuronal Plasticity: genetics, Neurons, Neurons: metabolism, Oligonucleotide Array Sequence Analysis, Physical Conditioning, Animal, Protein Transport, Protein Transport: genetics, Rats, Rats, Sprague-Dawley, Reaction Time, Reaction Time: genetics, Synaptic Vesicles, Synaptic Vesicles: genetics, Synaptic Vesicles: metabolism, Up-Regulation, Up-Regulation: genetics},
	pages = {1107--16},
}

{"_id":"fCWHATJ4GBrycX6an","bibbaseid":"molteni-ying-gmezpinilla-differentialeffectsofacuteandchronicexerciseonplasticityrelatedgenesintherathippocampusrevealedbymicroarray-2002","author_short":["Molteni, R.","Ying, Z.","Gómez-Pinilla, F."],"bibdata":{"bibtype":"article","type":"article","title":"Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray.","volume":"16","issn":"0953-816X","url":"http://www.ncbi.nlm.nih.gov/pubmed/12383240","abstract":"Studies were performed to determine the effects of acute and chronic voluntary periods of exercise on the expression of hippocampal genes. RNAs from rodents exposed to a running wheel for 3, 7 and 28 days were examined using a microarray with 1176 cDNAs expressed primarily in the brain. The expression of selected genes was quantified by Taqman RT-PCR or RNase protection assay. The largest up-regulation was observed in genes involved with synaptic trafficking (synapsin I, synaptotagmin and syntaxin); signal transduction pathways (Ca2+/calmodulin-dependent protein kinase II, CaM-KII; mitogen-activated/extracellular signal-regulated protein kinase, MAP-K/ERK I and II; protein kinase C, PKC-delta) or transcription regulators (cyclic AMP response element binding protein, CREB). Genes associated with the glutamatergic system were up-regulated (N-methyl-d-aspartate receptor, NMDAR-2A and NMDAR-2B and excitatory amino acid carrier 1, EAAC1), while genes related to the gamma-aminobutyric acid (GABA) system were down-regulated (GABAA receptor, glutamate decarboxylase GAD65). Brain-derived neurotrophic factor (BDNF) was the only trophic factor whose gene was consistently up-regulated at all timepoints. These results, together with the fact that most of the genes up-regulated have a recognized interaction with BDNF, suggest a central role for BDNF on the effects of exercise on brain plasticity. The temporal profile of gene expression seems to delineate a mechanism by which specific molecular pathways are activated after exercise performance. For example, the CaM-K signal system seems to be active during acute and chronic periods of exercise, while the MAP-K/ERK system seems more important during long-term exercise.","number":"6","urldate":"2014-02-03","journal":"The European journal of neuroscience","author":[{"propositions":[],"lastnames":["Molteni"],"firstnames":["Raffaella"],"suffixes":[]},{"propositions":[],"lastnames":["Ying"],"firstnames":["Zhe"],"suffixes":[]},{"propositions":[],"lastnames":["Gómez-Pinilla"],"firstnames":["Fernando"],"suffixes":[]}],"month":"September","year":"2002","pmid":"12383240","keywords":"Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: biosynthesis, Brain-Derived Neurotrophic Factor: genetics, DNA, Complementary, DNA, Complementary: analysis, DNA, Complementary: genetics, Gene Expression Regulation, Gene Expression Regulation: genetics, Genes, Regulator, Genes, Regulator: genetics, Hippocampus, Hippocampus: metabolism, MAP Kinase Signaling System, MAP Kinase Signaling System: genetics, Male, Nerve Growth Factors, Nerve Growth Factors: biosynthesis, Nerve Growth Factors: genetics, Nerve Tissue Proteins, Nerve Tissue Proteins: biosynthesis, Nerve Tissue Proteins: genetics, Neuronal Plasticity, Neuronal Plasticity: genetics, Neurons, Neurons: metabolism, Oligonucleotide Array Sequence Analysis, Physical Conditioning, Animal, Protein Transport, Protein Transport: genetics, Rats, Rats, Sprague-Dawley, Reaction Time, Reaction Time: genetics, Synaptic Vesicles, Synaptic Vesicles: genetics, Synaptic Vesicles: metabolism, Up-Regulation, Up-Regulation: genetics","pages":"1107–16","bibtex":"@article{molteni_differential_2002,\n\ttitle = {Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray.},\n\tvolume = {16},\n\tissn = {0953-816X},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/12383240},\n\tabstract = {Studies were performed to determine the effects of acute and chronic voluntary periods of exercise on the expression of hippocampal genes. RNAs from rodents exposed to a running wheel for 3, 7 and 28 days were examined using a microarray with 1176 cDNAs expressed primarily in the brain. The expression of selected genes was quantified by Taqman RT-PCR or RNase protection assay. The largest up-regulation was observed in genes involved with synaptic trafficking (synapsin I, synaptotagmin and syntaxin); signal transduction pathways (Ca2+/calmodulin-dependent protein kinase II, CaM-KII; mitogen-activated/extracellular signal-regulated protein kinase, MAP-K/ERK I and II; protein kinase C, PKC-delta) or transcription regulators (cyclic AMP response element binding protein, CREB). Genes associated with the glutamatergic system were up-regulated (N-methyl-d-aspartate receptor, NMDAR-2A and NMDAR-2B and excitatory amino acid carrier 1, EAAC1), while genes related to the gamma-aminobutyric acid (GABA) system were down-regulated (GABAA receptor, glutamate decarboxylase GAD65). Brain-derived neurotrophic factor (BDNF) was the only trophic factor whose gene was consistently up-regulated at all timepoints. These results, together with the fact that most of the genes up-regulated have a recognized interaction with BDNF, suggest a central role for BDNF on the effects of exercise on brain plasticity. The temporal profile of gene expression seems to delineate a mechanism by which specific molecular pathways are activated after exercise performance. For example, the CaM-K signal system seems to be active during acute and chronic periods of exercise, while the MAP-K/ERK system seems more important during long-term exercise.},\n\tnumber = {6},\n\turldate = {2014-02-03},\n\tjournal = {The European journal of neuroscience},\n\tauthor = {Molteni, Raffaella and Ying, Zhe and Gómez-Pinilla, Fernando},\n\tmonth = sep,\n\tyear = {2002},\n\tpmid = {12383240},\n\tkeywords = {Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: biosynthesis, Brain-Derived Neurotrophic Factor: genetics, DNA, Complementary, DNA, Complementary: analysis, DNA, Complementary: genetics, Gene Expression Regulation, Gene Expression Regulation: genetics, Genes, Regulator, Genes, Regulator: genetics, Hippocampus, Hippocampus: metabolism, MAP Kinase Signaling System, MAP Kinase Signaling System: genetics, Male, Nerve Growth Factors, Nerve Growth Factors: biosynthesis, Nerve Growth Factors: genetics, Nerve Tissue Proteins, Nerve Tissue Proteins: biosynthesis, Nerve Tissue Proteins: genetics, Neuronal Plasticity, Neuronal Plasticity: genetics, Neurons, Neurons: metabolism, Oligonucleotide Array Sequence Analysis, Physical Conditioning, Animal, Protein Transport, Protein Transport: genetics, Rats, Rats, Sprague-Dawley, Reaction Time, Reaction Time: genetics, Synaptic Vesicles, Synaptic Vesicles: genetics, Synaptic Vesicles: metabolism, Up-Regulation, Up-Regulation: genetics},\n\tpages = {1107--16},\n}\n\n","author_short":["Molteni, R.","Ying, Z.","Gómez-Pinilla, F."],"key":"molteni_differential_2002","id":"molteni_differential_2002","bibbaseid":"molteni-ying-gmezpinilla-differentialeffectsofacuteandchronicexerciseonplasticityrelatedgenesintherathippocampusrevealedbymicroarray-2002","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/12383240"},"keyword":["Animals","Brain-Derived Neurotrophic Factor","Brain-Derived Neurotrophic Factor: biosynthesis","Brain-Derived Neurotrophic Factor: genetics","DNA","Complementary","DNA","Complementary: analysis","DNA","Complementary: genetics","Gene Expression Regulation","Gene Expression Regulation: genetics","Genes","Regulator","Genes","Regulator: genetics","Hippocampus","Hippocampus: metabolism","MAP Kinase Signaling System","MAP Kinase Signaling System: genetics","Male","Nerve Growth Factors","Nerve Growth Factors: biosynthesis","Nerve Growth Factors: genetics","Nerve Tissue Proteins","Nerve Tissue Proteins: biosynthesis","Nerve Tissue Proteins: genetics","Neuronal Plasticity","Neuronal Plasticity: genetics","Neurons","Neurons: metabolism","Oligonucleotide Array Sequence Analysis","Physical Conditioning","Animal","Protein Transport","Protein Transport: genetics","Rats","Rats","Sprague-Dawley","Reaction Time","Reaction Time: genetics","Synaptic Vesicles","Synaptic Vesicles: genetics","Synaptic Vesicles: metabolism","Up-Regulation","Up-Regulation: genetics"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/asrommel","dataSources":["J8fbWsdsy3xAaB3pX"],"keywords":["animals","brain-derived neurotrophic factor","brain-derived neurotrophic factor: biosynthesis","brain-derived neurotrophic factor: genetics","dna","complementary","dna","complementary: analysis","dna","complementary: genetics","gene expression regulation","gene expression regulation: genetics","genes","regulator","genes","regulator: genetics","hippocampus","hippocampus: metabolism","map kinase signaling system","map kinase signaling system: genetics","male","nerve growth factors","nerve growth factors: biosynthesis","nerve growth factors: genetics","nerve tissue proteins","nerve tissue proteins: biosynthesis","nerve tissue proteins: genetics","neuronal plasticity","neuronal plasticity: genetics","neurons","neurons: metabolism","oligonucleotide array sequence analysis","physical conditioning","animal","protein transport","protein transport: genetics","rats","rats","sprague-dawley","reaction time","reaction time: genetics","synaptic vesicles","synaptic vesicles: genetics","synaptic vesicles: metabolism","up-regulation","up-regulation: genetics"],"search_terms":["differential","effects","acute","chronic","exercise","plasticity","related","genes","rat","hippocampus","revealed","microarray","molteni","ying","gómez-pinilla"],"title":"Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray.","year":2002}