Multi-Arm Star-Shaped Glycopolymers with Precisely Controlled Core Size and Arm Length. Monaco, A., Beyer, V. P., Napier, R., & Becer, C. R. BIOMACROMOLECULES, 21(9):3736–3744, September, 2020. doi abstract bibtex Star-shaped glycopolymers provide very high binding activities toward lectins. However, a straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerization in aqueous media. D-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core cross-linked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated, and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the lower critical solution temperature (LCST) of P(NIPAM).
@article{monaco_multi-arm_2020,
title = {Multi-{Arm} {Star}-{Shaped} {Glycopolymers} with {Precisely} {Controlled} {Core} {Size} and {Arm} {Length}},
volume = {21},
issn = {1525-7797},
doi = {10.1021/acs.biomac.0c00838},
abstract = {Star-shaped glycopolymers provide very high binding activities toward lectins. However, a straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerization in aqueous media. D-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core cross-linked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated, and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the lower critical solution temperature (LCST) of P(NIPAM).},
number = {9},
urldate = {2020-10-09},
journal = {BIOMACROMOLECULES},
author = {Monaco, Alessandra and Beyer, Valentin P. and Napier, Richard and Becer, C. Remzi},
month = sep,
year = {2020},
pages = {3736--3744},
}
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