@article{RN345,
   author = {Monereo-Sanchez, J. and Jansen, J. F. A. and van Boxtel, M. P. J. and Backes, W. H. and Kohler, S. and Stehouwer, C. D. A. and Linden, D. E. J. and Schram, M. T.},
   title = {Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study},
   journal = {Br J Psychiatry},
   pages = {1-8},
   note = {Monereo-Sanchez, Jennifer
Jansen, Jacobus F A
van Boxtel, Martin P J
Backes, Walter H
Kohler, Sebastian
Stehouwer, Coen D A
Linden, David E J
Schram, Miranda T
eng
31O.041/European Regional Development Fund/
England
Br J Psychiatry. 2023 Nov 23:1-8. doi: 10.1192/bjp.2023.143.},
   abstract = {BACKGROUND: Late-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time. AIMS: We investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms. METHOD: We extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using T(1)-weighted and fluid-attenuated inversion recovery 3T magnetic resonance images. Depressive symptoms were assessed at baseline and annually over 7 years of follow-up (9-item Patient Health Questionnaire). We used negative binominal, logistic, and Cox regression analyses, corrected for multiple comparisons, and adjusted for demographic, cardiovascular and lifestyle factors. RESULTS: A total of n = 4174 participants were included (mean age 60.0 years, s.d. = 8.6, 51.8% female). Larger right hippocampal fissure volume was associated with prevalent depressive symptoms (odds ratio (OR) = 1.26, 95% CI 1.08-1.48). Larger bilateral hippocampal fissure (OR = 1.37-1.40, 95% CI 1.14-1.71), larger right molecular layer (OR = 1.51, 95% CI 1.14-2.00) and smaller right cornu ammonis (CA)3 volumes (OR = 0.61, 95% CI 0.48-0.79) were associated with prevalent depressive symptoms with a chronic course. No associations of hippocampal subfield volumes with incident depressive symptoms were found. Yet, lower left hippocampal amygdala transition area (HATA) volume was associated with incident depressive symptoms with chronic course (hazard ratio = 0.70, 95% CI 0.55-0.89). CONCLUSIONS: Differences in hippocampal fissure, molecular layer and CA volumes might co-occur or follow the onset of depressive symptoms, in particular with a chronic course. Smaller HATA was associated with an increased risk of incident (chronic) depression. Our results could capture a biological foundation for the development of chronic depressive symptoms, and stresses the need to discriminate subtypes of depression to unravel its biological underpinnings.},
   keywords = {Magnetic resonance imaging
cognitive neuroscience
depressive disorders
neuroanatomy
neuropathology},
   ISSN = {1472-1465 (Electronic)
0007-1250 (Linking)},
   DOI = {10.1192/bjp.2023.143},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/37993980},
   year = {2023},
   type = {Journal Article}
}

{"_id":"TMBRLRwifXTTjgZoL","bibbaseid":"monereosanchez-jansen-vanboxtel-backes-kohler-stehouwer-linden-schram-associationofhippocampalsubfieldvolumeswithprevalencecourseandincidenceofdepressivesymptomsthemaastrichtstudy-2023","author_short":["Monereo-Sanchez, J.","Jansen, J. F. A.","van Boxtel, M. P. J.","Backes, W. H.","Kohler, S.","Stehouwer, C. D. A.","Linden, D. E. J.","Schram, M. T."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Monereo-Sanchez"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Linden"],"firstnames":["D.","E.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]}],"title":"Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study","journal":"Br J Psychiatry","pages":"1-8","note":"Monereo-Sanchez, Jennifer Jansen, Jacobus F A van Boxtel, Martin P J Backes, Walter H Kohler, Sebastian Stehouwer, Coen D A Linden, David E J Schram, Miranda T eng 31O.041/European Regional Development Fund/ England Br J Psychiatry. 2023 Nov 23:1-8. doi: 10.1192/bjp.2023.143.","abstract":"BACKGROUND: Late-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time. AIMS: We investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms. METHOD: We extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using T(1)-weighted and fluid-attenuated inversion recovery 3T magnetic resonance images. Depressive symptoms were assessed at baseline and annually over 7 years of follow-up (9-item Patient Health Questionnaire). We used negative binominal, logistic, and Cox regression analyses, corrected for multiple comparisons, and adjusted for demographic, cardiovascular and lifestyle factors. RESULTS: A total of n = 4174 participants were included (mean age 60.0 years, s.d. = 8.6, 51.8% female). Larger right hippocampal fissure volume was associated with prevalent depressive symptoms (odds ratio (OR) = 1.26, 95% CI 1.08-1.48). Larger bilateral hippocampal fissure (OR = 1.37-1.40, 95% CI 1.14-1.71), larger right molecular layer (OR = 1.51, 95% CI 1.14-2.00) and smaller right cornu ammonis (CA)3 volumes (OR = 0.61, 95% CI 0.48-0.79) were associated with prevalent depressive symptoms with a chronic course. No associations of hippocampal subfield volumes with incident depressive symptoms were found. Yet, lower left hippocampal amygdala transition area (HATA) volume was associated with incident depressive symptoms with chronic course (hazard ratio = 0.70, 95% CI 0.55-0.89). CONCLUSIONS: Differences in hippocampal fissure, molecular layer and CA volumes might co-occur or follow the onset of depressive symptoms, in particular with a chronic course. Smaller HATA was associated with an increased risk of incident (chronic) depression. Our results could capture a biological foundation for the development of chronic depressive symptoms, and stresses the need to discriminate subtypes of depression to unravel its biological underpinnings.","keywords":"Magnetic resonance imaging cognitive neuroscience depressive disorders neuroanatomy neuropathology","issn":"1472-1465 (Electronic) 0007-1250 (Linking)","doi":"10.1192/bjp.2023.143","url":"https://www.ncbi.nlm.nih.gov/pubmed/37993980","year":"2023","bibtex":"@article{RN345,\n author = {Monereo-Sanchez, J. and Jansen, J. F. A. and van Boxtel, M. P. J. and Backes, W. H. and Kohler, S. and Stehouwer, C. D. A. and Linden, D. E. J. and Schram, M. T.},\n title = {Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study},\n journal = {Br J Psychiatry},\n pages = {1-8},\n note = {Monereo-Sanchez, Jennifer\nJansen, Jacobus F A\nvan Boxtel, Martin P J\nBackes, Walter H\nKohler, Sebastian\nStehouwer, Coen D A\nLinden, David E J\nSchram, Miranda T\neng\n31O.041/European Regional Development Fund/\nEngland\nBr J Psychiatry. 2023 Nov 23:1-8. doi: 10.1192/bjp.2023.143.},\n abstract = {BACKGROUND: Late-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time. AIMS: We investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms. METHOD: We extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using T(1)-weighted and fluid-attenuated inversion recovery 3T magnetic resonance images. Depressive symptoms were assessed at baseline and annually over 7 years of follow-up (9-item Patient Health Questionnaire). We used negative binominal, logistic, and Cox regression analyses, corrected for multiple comparisons, and adjusted for demographic, cardiovascular and lifestyle factors. RESULTS: A total of n = 4174 participants were included (mean age 60.0 years, s.d. = 8.6, 51.8% female). Larger right hippocampal fissure volume was associated with prevalent depressive symptoms (odds ratio (OR) = 1.26, 95% CI 1.08-1.48). Larger bilateral hippocampal fissure (OR = 1.37-1.40, 95% CI 1.14-1.71), larger right molecular layer (OR = 1.51, 95% CI 1.14-2.00) and smaller right cornu ammonis (CA)3 volumes (OR = 0.61, 95% CI 0.48-0.79) were associated with prevalent depressive symptoms with a chronic course. No associations of hippocampal subfield volumes with incident depressive symptoms were found. Yet, lower left hippocampal amygdala transition area (HATA) volume was associated with incident depressive symptoms with chronic course (hazard ratio = 0.70, 95% CI 0.55-0.89). CONCLUSIONS: Differences in hippocampal fissure, molecular layer and CA volumes might co-occur or follow the onset of depressive symptoms, in particular with a chronic course. Smaller HATA was associated with an increased risk of incident (chronic) depression. Our results could capture a biological foundation for the development of chronic depressive symptoms, and stresses the need to discriminate subtypes of depression to unravel its biological underpinnings.},\n keywords = {Magnetic resonance imaging\ncognitive neuroscience\ndepressive disorders\nneuroanatomy\nneuropathology},\n ISSN = {1472-1465 (Electronic)\n0007-1250 (Linking)},\n DOI = {10.1192/bjp.2023.143},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/37993980},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Monereo-Sanchez, J.","Jansen, J. F. A.","van Boxtel, M. P. J.","Backes, W. H.","Kohler, S.","Stehouwer, C. D. A.","Linden, D. E. J.","Schram, M. T."],"key":"RN345","id":"RN345","bibbaseid":"monereosanchez-jansen-vanboxtel-backes-kohler-stehouwer-linden-schram-associationofhippocampalsubfieldvolumeswithprevalencecourseandincidenceofdepressivesymptomsthemaastrichtstudy-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/37993980"},"keyword":["Magnetic resonance imaging cognitive neuroscience depressive disorders neuroanatomy neuropathology"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["magnetic resonance imaging cognitive neuroscience depressive disorders neuroanatomy neuropathology"],"search_terms":["association","hippocampal","subfield","volumes","prevalence","course","incidence","depressive","symptoms","maastricht","study","monereo-sanchez","jansen","van boxtel","backes","kohler","stehouwer","linden","schram"],"title":"Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study","year":2023}