A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect against Salmonella Typhimurium. Monteiro, G. P., Melo, R. T. d., Guidotti-Takeuchi, M., Dumont, C. F., Ribeiro, R. A. C., Guerra, W., Ramos, L. M. S., Paixão, D. A., Santos, F. A. L. D., Rodrigues, D. D. P., Boleij, P., Hoepers, P. G., & Rossi, D. A. Antibiotics, 11(3):1–17, 2022. doi abstract bibtex Salmonella spp. continues to figure prominently in world epidemiological registries as one of the leading causes of bacterial foodborne disease. We characterised 43 Brazilian lineages of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II) complex as control options, and proposed effective antimicrobial measures. The minimum in-hibitory concentration was evaluated for seven antimicrobials, isolated and combined with the copper (II) complex [Cu(4-FH)(phen)(ClO4 )2 ] (4-FH = 4-fluorophenoxyacetic acid hydrazide and phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to car-bapenems and polymyxins (86 and 88%, respectively) have drawn attention to the emergence of the problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67%, respectively), the drugs of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM /blaCTX-M in 39% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 µM) controlled planktonic and sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST, respectively, and represents promising alternatives for the control of MDR ST.
@article{monteiro_ternary_2022,
title = {A {Ternary} {Copper} ({II}) {Complex} with 4-{Fluorophenoxyacetic} {Acid} {Hydrazide} in {Combination} with {Antibiotics} {Exhibits} {Positive} {Synergistic} {Effect} against {Salmonella} {Typhimurium}},
volume = {11},
issn = {20796382},
doi = {10.3390/antibiotics11030388},
abstract = {Salmonella spp. continues to figure prominently in world epidemiological registries as one of the leading causes of bacterial foodborne disease. We characterised 43 Brazilian lineages of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II) complex as control options, and proposed effective antimicrobial measures. The minimum in-hibitory concentration was evaluated for seven antimicrobials, isolated and combined with the copper (II) complex [Cu(4-FH)(phen)(ClO4 )2 ] (4-FH = 4-fluorophenoxyacetic acid hydrazide and phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to car-bapenems and polymyxins (86 and 88\%, respectively) have drawn attention to the emergence of the problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67\%, respectively), the drugs of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM /blaCTX-M in 39\% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 µM) controlled planktonic and sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST, respectively, and represents promising alternatives for the control of MDR ST.},
number = {3},
journal = {Antibiotics},
author = {Monteiro, Guilherme Paz and Melo, Roberta Torres de and Guidotti-Takeuchi, Micaela and Dumont, Carolyne Ferreira and Ribeiro, Rosanne Aparecida Capanema and Guerra, Wendell and Ramos, Luana Munique Sousa and Paixão, Drielly Aparecida and Santos, Fernanda Aparecida Longato Dos and Rodrigues, Dália Dos Prazeres and Boleij, Peter and Hoepers, Patrícia Giovana and Rossi, Daise Aparecida},
year = {2022},
keywords = {food safety, multi drug resistance (MDR), salmonellosis},
pages = {1--17},
}
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We characterised 43 Brazilian lineages of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II) complex as control options, and proposed effective antimicrobial measures. The minimum in-hibitory concentration was evaluated for seven antimicrobials, isolated and combined with the copper (II) complex [Cu(4-FH)(phen)(ClO4 )2 ] (4-FH = 4-fluorophenoxyacetic acid hydrazide and phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to car-bapenems and polymyxins (86 and 88%, respectively) have drawn attention to the emergence of the problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67%, respectively), the drugs of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM /blaCTX-M in 39% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 µM) controlled planktonic and sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST, respectively, and represents promising alternatives for the control of MDR ST.","number":"3","journal":"Antibiotics","author":[{"propositions":[],"lastnames":["Monteiro"],"firstnames":["Guilherme","Paz"],"suffixes":[]},{"propositions":[],"lastnames":["Melo"],"firstnames":["Roberta","Torres","de"],"suffixes":[]},{"propositions":[],"lastnames":["Guidotti-Takeuchi"],"firstnames":["Micaela"],"suffixes":[]},{"propositions":[],"lastnames":["Dumont"],"firstnames":["Carolyne","Ferreira"],"suffixes":[]},{"propositions":[],"lastnames":["Ribeiro"],"firstnames":["Rosanne","Aparecida","Capanema"],"suffixes":[]},{"propositions":[],"lastnames":["Guerra"],"firstnames":["Wendell"],"suffixes":[]},{"propositions":[],"lastnames":["Ramos"],"firstnames":["Luana","Munique","Sousa"],"suffixes":[]},{"propositions":[],"lastnames":["Paixão"],"firstnames":["Drielly","Aparecida"],"suffixes":[]},{"propositions":[],"lastnames":["Santos"],"firstnames":["Fernanda","Aparecida","Longato","Dos"],"suffixes":[]},{"propositions":[],"lastnames":["Rodrigues"],"firstnames":["Dália","Dos","Prazeres"],"suffixes":[]},{"propositions":[],"lastnames":["Boleij"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Hoepers"],"firstnames":["Patrícia","Giovana"],"suffixes":[]},{"propositions":[],"lastnames":["Rossi"],"firstnames":["Daise","Aparecida"],"suffixes":[]}],"year":"2022","keywords":"food safety, multi drug resistance (MDR), salmonellosis","pages":"1–17","bibtex":"@article{monteiro_ternary_2022,\n\ttitle = {A {Ternary} {Copper} ({II}) {Complex} with 4-{Fluorophenoxyacetic} {Acid} {Hydrazide} in {Combination} with {Antibiotics} {Exhibits} {Positive} {Synergistic} {Effect} against {Salmonella} {Typhimurium}},\n\tvolume = {11},\n\tissn = {20796382},\n\tdoi = {10.3390/antibiotics11030388},\n\tabstract = {Salmonella spp. continues to figure prominently in world epidemiological registries as one of the leading causes of bacterial foodborne disease. We characterised 43 Brazilian lineages of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II) complex as control options, and proposed effective antimicrobial measures. The minimum in-hibitory concentration was evaluated for seven antimicrobials, isolated and combined with the copper (II) complex [Cu(4-FH)(phen)(ClO4 )2 ] (4-FH = 4-fluorophenoxyacetic acid hydrazide and phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to car-bapenems and polymyxins (86 and 88\\%, respectively) have drawn attention to the emergence of the problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67\\%, respectively), the drugs of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM /blaCTX-M in 39\\% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 µM) controlled planktonic and sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST, respectively, and represents promising alternatives for the control of MDR ST.},\n\tnumber = {3},\n\tjournal = {Antibiotics},\n\tauthor = {Monteiro, Guilherme Paz and Melo, Roberta Torres de and Guidotti-Takeuchi, Micaela and Dumont, Carolyne Ferreira and Ribeiro, Rosanne Aparecida Capanema and Guerra, Wendell and Ramos, Luana Munique Sousa and Paixão, Drielly Aparecida and Santos, Fernanda Aparecida Longato Dos and Rodrigues, Dália Dos Prazeres and Boleij, Peter and Hoepers, Patrícia Giovana and Rossi, Daise Aparecida},\n\tyear = {2022},\n\tkeywords = {food safety, multi drug resistance (MDR), salmonellosis},\n\tpages = {1--17},\n}\n\n\n\n","author_short":["Monteiro, G. P.","Melo, R. 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