Catatonia in autism and other neurodevelopmental disabilities: a state-of-the-art review. Moore, S., Amatya, D. N, Chu, M. M, & Besterman, A. D Npj Ment Health Res, 1(1):12, Springer Science and Business Media LLC, September, 2022. abstract bibtex Individuals with neurodevelopmental disabilities (NDDs) may be at increased risk for catatonia, which can be an especially challenging condition to diagnose and treat. There may be symptom overlap between catatonia and NDD-associated behaviors, such as stereotypies. The diagnosis of catatonia should perhaps be adjusted to address symptom overlap and to include extreme behaviors observed in patients with NDDs, such as severe self-injury. Risk factors for catatonia in individuals with NDDs may include trauma and certain genetic variants, such as those that disrupt SHANK3. Common etiologic features between neurodevelopmental disabilities and catatonia, such as excitatory/inhibitory imbalance and neuroimmune dysfunction, may partially account for comorbidity. New approaches leveraging genetic testing and neuroimmunologic evaluation may allow for more precise diagnoses and effective treatments.
@ARTICLE{Moore2022-vv,
title = "Catatonia in autism and other neurodevelopmental disabilities: a
state-of-the-art review",
author = "Moore, Shavon and Amatya, Debha N and Chu, Michael M and
Besterman, Aaron D",
abstract = "Individuals with neurodevelopmental disabilities (NDDs) may be
at increased risk for catatonia, which can be an especially
challenging condition to diagnose and treat. There may be
symptom overlap between catatonia and NDD-associated behaviors,
such as stereotypies. The diagnosis of catatonia should perhaps
be adjusted to address symptom overlap and to include extreme
behaviors observed in patients with NDDs, such as severe
self-injury. Risk factors for catatonia in individuals with NDDs
may include trauma and certain genetic variants, such as those
that disrupt SHANK3. Common etiologic features between
neurodevelopmental disabilities and catatonia, such as
excitatory/inhibitory imbalance and neuroimmune dysfunction, may
partially account for comorbidity. New approaches leveraging
genetic testing and neuroimmunologic evaluation may allow for
more precise diagnoses and effective treatments.",
journal = "Npj Ment Health Res",
publisher = "Springer Science and Business Media LLC",
volume = 1,
number = 1,
pages = "12",
month = sep,
year = 2022,
copyright = "https://creativecommons.org/licenses/by/4.0",
language = "en"
}
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