Synthesis of distamycin A polyamides targeting G-quadruplex DNA.

Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Moore, M. J B, Cuenca, F., Searcey, M., & Neidle, S. Organic & biomolecular chemistry, 4(18):3479–88, October, 2006.

Paper doi abstract bibtex

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode.

@article{Moore2006,
	title = {Synthesis of distamycin {A} polyamides targeting {G}-quadruplex {DNA}.},
	volume = {4},
	issn = {1477-0520},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17036143},
	doi = {10.1039/b607707b},
	abstract = {A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode.},
	number = {18},
	journal = {Organic \& biomolecular chemistry},
	author = {Moore, Michael J B and Cuenca, Francisco and Searcey, Mark and Neidle, Stephen},
	month = oct,
	year = {2006},
	pmid = {17036143},
	keywords = {\#nosource, DNA, DNA: chemistry, Dimerization, Distamycins, Distamycins: chemical synthesis, Distamycins: chemistry, Fluorescence Resonance Energy Transfer, G-Quadruplexes, Humans, Models, Molecular, Nylons, Nylons: chemical synthesis, Nylons: chemistry, Thermodynamics},
	pages = {3479--88},
}

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