Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules. Morasch, M., Liu, J., Dirscherl, C. F., Ianeselli, A., Kühnlein, A., Le Vay, K., Schwintek, P., Islam, S., Corpinot, M. K., Scheu, B., Dingwell, D. B., Schwille, P., Mutschler, H., Powner, M. W., Mast, C. B., & Braun, D. Nature Chemistry, 11(9):779–788, 2019. doi abstract bibtex Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and continuous enrichment in a long-lasting environment. Here, we explore how gas bubbles in water subjected to a thermal gradient, a likely scenario within crustal mafic rocks on the early Earth, drive a complex, continuous enrichment of prebiotic molecules. RNA precursors, monomers, active ribozymes, oligonucleotides and lipids are shown to (1) cycle between dry and wet states, enabling the central step of RNA phosphorylation, (2) accumulate at the gas–water interface to drastically increase ribozymatic activity, (3) condense into hydrogels, (4) form pure crystals and (5) encapsulate into protecting vesicle aggregates that subsequently undergo fission. These effects occur within less than 30 min. The findings unite, in one location, the physical conditions that were crucial for the chemical emergence of biopolymers. They suggest that heated microbubbles could have hosted the first cycles of molecular evolution.
@article{Morasch2019,
abstract = {Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and continuous enrichment in a long-lasting environment. Here, we explore how gas bubbles in water subjected to a thermal gradient, a likely scenario within crustal mafic rocks on the early Earth, drive a complex, continuous enrichment of prebiotic molecules. RNA precursors, monomers, active ribozymes, oligonucleotides and lipids are shown to (1) cycle between dry and wet states, enabling the central step of RNA phosphorylation, (2) accumulate at the gas–water interface to drastically increase ribozymatic activity, (3) condense into hydrogels, (4) form pure crystals and (5) encapsulate into protecting vesicle aggregates that subsequently undergo fission. These effects occur within less than 30 min. The findings unite, in one location, the physical conditions that were crucial for the chemical emergence of biopolymers. They suggest that heated microbubbles could have hosted the first cycles of molecular evolution.},
author = {Morasch, Matthias and Liu, Jonathan and Dirscherl, Christina F. and Ianeselli, Alan and K{\"{u}}hnlein, Alexandra and {Le Vay}, Kristian and Schwintek, Philipp and Islam, Saidul and Corpinot, M{\'{e}}rina K. and Scheu, Bettina and Dingwell, Donald B. and Schwille, Petra and Mutschler, Hannes and Powner, Matthew W. and Mast, Christof B. and Braun, Dieter},
doi = {10.1038/s41557-019-0299-5},
issn = {17554349},
journal = {Nature Chemistry},
number = {9},
pages = {779--788},
pmid = {31358919},
title = {{Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules}},
volume = {11},
year = {2019}
}
Downloads: 0
{"_id":"8TF9mWTePfvPxRAH5","bibbaseid":"morasch-liu-dirscherl-ianeselli-khnlein-levay-schwintek-islam-etal-heatedgasbubblesenrichcrystallizedryphosphorylateandencapsulateprebioticmolecules-2019","authorIDs":["38kWX4KNdemC8LePC","ACBJim4Zh8wmGTkCn","iMh9dPmru8GvT3mZ5","jAwdzkP7zNRfmiqix","srCdKMLurqnxjZxgi","x4TZgwqj3xbovb4re"],"author_short":["Morasch, M.","Liu, J.","Dirscherl, C. F.","Ianeselli, A.","Kühnlein, A.","Le Vay, K.","Schwintek, P.","Islam, S.","Corpinot, M. K.","Scheu, B.","Dingwell, D. B.","Schwille, P.","Mutschler, H.","Powner, M. W.","Mast, C. B.","Braun, D."],"bibdata":{"bibtype":"article","type":"article","abstract":"Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and continuous enrichment in a long-lasting environment. Here, we explore how gas bubbles in water subjected to a thermal gradient, a likely scenario within crustal mafic rocks on the early Earth, drive a complex, continuous enrichment of prebiotic molecules. RNA precursors, monomers, active ribozymes, oligonucleotides and lipids are shown to (1) cycle between dry and wet states, enabling the central step of RNA phosphorylation, (2) accumulate at the gas–water interface to drastically increase ribozymatic activity, (3) condense into hydrogels, (4) form pure crystals and (5) encapsulate into protecting vesicle aggregates that subsequently undergo fission. These effects occur within less than 30 min. The findings unite, in one location, the physical conditions that were crucial for the chemical emergence of biopolymers. They suggest that heated microbubbles could have hosted the first cycles of molecular evolution.","author":[{"propositions":[],"lastnames":["Morasch"],"firstnames":["Matthias"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Jonathan"],"suffixes":[]},{"propositions":[],"lastnames":["Dirscherl"],"firstnames":["Christina","F."],"suffixes":[]},{"propositions":[],"lastnames":["Ianeselli"],"firstnames":["Alan"],"suffixes":[]},{"propositions":[],"lastnames":["Kühnlein"],"firstnames":["Alexandra"],"suffixes":[]},{"propositions":[],"lastnames":["Le Vay"],"firstnames":["Kristian"],"suffixes":[]},{"propositions":[],"lastnames":["Schwintek"],"firstnames":["Philipp"],"suffixes":[]},{"propositions":[],"lastnames":["Islam"],"firstnames":["Saidul"],"suffixes":[]},{"propositions":[],"lastnames":["Corpinot"],"firstnames":["Mérina","K."],"suffixes":[]},{"propositions":[],"lastnames":["Scheu"],"firstnames":["Bettina"],"suffixes":[]},{"propositions":[],"lastnames":["Dingwell"],"firstnames":["Donald","B."],"suffixes":[]},{"propositions":[],"lastnames":["Schwille"],"firstnames":["Petra"],"suffixes":[]},{"propositions":[],"lastnames":["Mutschler"],"firstnames":["Hannes"],"suffixes":[]},{"propositions":[],"lastnames":["Powner"],"firstnames":["Matthew","W."],"suffixes":[]},{"propositions":[],"lastnames":["Mast"],"firstnames":["Christof","B."],"suffixes":[]},{"propositions":[],"lastnames":["Braun"],"firstnames":["Dieter"],"suffixes":[]}],"doi":"10.1038/s41557-019-0299-5","issn":"17554349","journal":"Nature Chemistry","number":"9","pages":"779–788","pmid":"31358919","title":"Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules","volume":"11","year":"2019","bibtex":"@article{Morasch2019,\r\nabstract = {Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and continuous enrichment in a long-lasting environment. Here, we explore how gas bubbles in water subjected to a thermal gradient, a likely scenario within crustal mafic rocks on the early Earth, drive a complex, continuous enrichment of prebiotic molecules. RNA precursors, monomers, active ribozymes, oligonucleotides and lipids are shown to (1) cycle between dry and wet states, enabling the central step of RNA phosphorylation, (2) accumulate at the gas–water interface to drastically increase ribozymatic activity, (3) condense into hydrogels, (4) form pure crystals and (5) encapsulate into protecting vesicle aggregates that subsequently undergo fission. These effects occur within less than 30 min. The findings unite, in one location, the physical conditions that were crucial for the chemical emergence of biopolymers. They suggest that heated microbubbles could have hosted the first cycles of molecular evolution.},\r\nauthor = {Morasch, Matthias and Liu, Jonathan and Dirscherl, Christina F. and Ianeselli, Alan and K{\\\"{u}}hnlein, Alexandra and {Le Vay}, Kristian and Schwintek, Philipp and Islam, Saidul and Corpinot, M{\\'{e}}rina K. and Scheu, Bettina and Dingwell, Donald B. and Schwille, Petra and Mutschler, Hannes and Powner, Matthew W. and Mast, Christof B. and Braun, Dieter},\r\ndoi = {10.1038/s41557-019-0299-5},\r\nissn = {17554349},\r\njournal = {Nature Chemistry},\r\nnumber = {9},\r\npages = {779--788},\r\npmid = {31358919},\r\ntitle = {{Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules}},\r\nvolume = {11},\r\nyear = {2019}\r\n}\r\n","author_short":["Morasch, M.","Liu, J.","Dirscherl, C. F.","Ianeselli, A.","Kühnlein, A.","Le Vay, K.","Schwintek, P.","Islam, S.","Corpinot, M. K.","Scheu, B.","Dingwell, D. B.","Schwille, P.","Mutschler, H.","Powner, M. W.","Mast, C. B.","Braun, D."],"key":"Morasch2019","id":"Morasch2019","bibbaseid":"morasch-liu-dirscherl-ianeselli-khnlein-levay-schwintek-islam-etal-heatedgasbubblesenrichcrystallizedryphosphorylateandencapsulateprebioticmolecules-2019","role":"author","urls":{},"metadata":{"authorlinks":{"powner, m":"https://bibbase.org/show?bib=benjaminthoma.github.io%2Fpubs.bib"}},"downloads":0},"bibtype":"article","biburl":"benjaminthoma.github.io/pubs.bib","creationDate":"2020-06-26T14:21:50.346Z","downloads":0,"keywords":[],"search_terms":["heated","gas","bubbles","enrich","crystallize","dry","phosphorylate","encapsulate","prebiotic","molecules","morasch","liu","dirscherl","ianeselli","kühnlein","le vay","schwintek","islam","corpinot","scheu","dingwell","schwille","mutschler","powner","mast","braun"],"title":"Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules","year":2019,"dataSources":["9KEjTYsWfRuZ6w4rN","yni5TKeSthCoJvNNf","mdpZLZEzva4rFp2vp"]}