@article{
 title = {Founder effects and genetic variability in Quebec},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Chromosomes,DNA,DNA: genetics,Female,Founder Effect,Gene Frequency,Genetic Markers,Genetic Variation,Geography,Human,Humans,Male,Quebec,X,Y},
 pages = {1008-13},
 volume = {23},
 month = {11},
 id = {298ba221-215f-3d36-9166-f5a029688278},
 created = {2017-06-19T13:46:48.568Z},
 accessed = {2011-02-17},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:46:48.698Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Knowledge of the genetic population structure lies at the heart of mapping studies aiming genes responsible for Mendelian and complex traits. The Quebec population, which is of mostly French descent, is considered an excellent model for such genetic epidemiological endeavours because it is a young founder population. Yet, the assessment of the founder effect has relied mostly on the observed distribution of monogenic diseases and on the analysis of the underlying mutations with investigations focusing on the Saguenay region. To eliminate this clinical bias and to obtain a more complete image of the genetic diversity, different regional populations of Quebec were investigated by analysing neutral markers that represent maternal, paternal and X chromosome lineages. Results indicate that Quebec does not appear more homogeneous nor significantly different from European populations. However, a series of regional founder effects, particularly visible at the level of rare variants, are observed. These effects can be explained by the successive migrations of descendants of the first immigrants from the initial sites of settlement towards the outer regions. Depending on the number of founders and their diversity, as well as on the degree of isolation and the magnitude of the interbreeding with the neighbouring or local populations, such as Amerindians or later migrants, the consequences of these regional founder effects are more or less detectable in the contemporary population.},
 bibtype = {article},
 author = {Moreau, Claudia and Vézina, Hélène and Labuda, Damian},
 journal = {Médecine sciences : M/S},
 number = {11}
}

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