Chromatin signatures of cancer. Morgan, M. A and Shilatifard, A. Genes Dev., 29(3):238--249, 1~February, 2015.
doi  abstract   bibtex   
Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors.
@ARTICLE{Morgan2015-tr,
  title    = "Chromatin signatures of cancer",
  author   = "Morgan, Marc A and Shilatifard, Ali",
  abstract = "Changes in the pattern of gene expression play an important role
              in allowing cancer cells to acquire their hallmark
              characteristics, while genomic instability enables cells to
              acquire genetic alterations that promote oncogenesis. Chromatin
              plays central roles in both transcriptional regulation and the
              maintenance of genomic stability. Studies by cancer genome
              consortiums have identified frequent mutations in genes encoding
              chromatin regulatory factors and histone proteins in human
              cancer, implicating them as major mediators in the pathogenesis
              of both hematological malignancies and solid tumors. Here, we
              review recent advances in our understanding of the role of
              chromatin in cancer, focusing on transcriptional regulatory
              complexes, enhancer-associated factors, histone point mutations,
              and alterations in heterochromatin-interacting factors.",
  journal  = "Genes Dev.",
  volume   =  29,
  number   =  3,
  pages    = "238--249",
  month    =  "1~" # feb,
  year     =  2015,
  keywords = "zotero;chromatin;review;evolution;Zotero Import (Aug 30);Zotero
              Import (Aug 30)/My
              Library;Classics;Reviews/Epigenome;RaiLab;Reviews/Evolution",
  language = "en",
  issn     = "0890-9369, 1549-5477",
  pmid     = "25644600",
  doi      = "10.1101/gad.255182.114"
}
Downloads: 0