Characterization Across a Dispersity: Polymer Mass Spectrometry in the Second Dimension. Morgan, T. E., Wootton, C. A., Marzullo, B., Paris, J., Kerr, A., Ellacott, S. H., van Agthoven, M. A., Barrow, M. P., Bristow, A. W. T., Perrier, S., & O'Connor, P. B. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 32(8):2153–2161, August, 2021. doi abstract bibtex Due to the natural dispersity that is present in synthetic polymers, an added complexity is always present in the analysis of polymeric species. Tandem mass spectrometry analysis requires the isolation of individual precursors before a fragmentation event to allow the unambiguous characterization of these species and is not viable at certain levels of complexity due to achievable isolation widths. Two-dimensional mass spectrometry (2DMS) fragments ions and correlates fragments with their corresponding precursors without the need for isolation. In this study, 2DMS electron capture dissociation (ECD) fragmentation of a polyoxazoline and polyacrylamide species was carried out, resulting in the analysis of byproducts and individual polymer species without the use of chromatographic techniques. This study shows that 2DMS ECD is a powerful tool for the analysis of polyacrylamide and polyoxazoline species and offers a new dimension in the characterization of polymers.
@article{morgan_characterization_2021,
title = {Characterization {Across} a {Dispersity}: {Polymer} {Mass} {Spectrometry} in the {Second} {Dimension}},
volume = {32},
issn = {1044-0305},
doi = {10.1021/jasms.1c00106},
abstract = {Due to the natural dispersity that is present in synthetic polymers, an added complexity is always present in the analysis of polymeric species. Tandem mass spectrometry analysis requires the isolation of individual precursors before a fragmentation event to allow the unambiguous characterization of these species and is not viable at certain levels of complexity due to achievable isolation widths. Two-dimensional mass spectrometry (2DMS) fragments ions and correlates fragments with their corresponding precursors without the need for isolation. In this study, 2DMS electron capture dissociation (ECD) fragmentation of a polyoxazoline and polyacrylamide species was carried out, resulting in the analysis of byproducts and individual polymer species without the use of chromatographic techniques. This study shows that 2DMS ECD is a powerful tool for the analysis of polyacrylamide and polyoxazoline species and offers a new dimension in the characterization of polymers.},
number = {8},
urldate = {2021-11-19},
journal = {JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY},
author = {Morgan, Tomos E. and Wootton, Christopher A. and Marzullo, Bryan and Paris, Johanna and Kerr, Andrew and Ellacott, Sean H. and van Agthoven, Maria A. and Barrow, Mark P. and Bristow, Anthony W. T. and Perrier, Sebastien and O'Connor, Peter B.},
month = aug,
year = {2021},
pages = {2153--2161},
}
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