Fragment-based hit identification: thinking in 3D. Morley, A., D., Pugliese, A., Birchall, K., Bower, J., Brennan, P., Brown, N., Chapman, T., Drysdale, M., Gilbert, I., H., Hoelder, S., Jordan, A., Ley, S., V., Merritt, A., Miller, D., Swarbrick, M., E., & Wyatt, P., G. Drug discovery today, 18(23-24):1221-7, 2013. ![Fragment-based hit identification: thinking in 3D. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.
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title = {Fragment-based hit identification: thinking in 3D.},
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year = {2013},
pages = {1221-7},
volume = {18},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/23906694},
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abstract = {The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.},
bibtype = {article},
author = {Morley, Andrew D. and Pugliese, Angelo and Birchall, Kristian and Bower, Justin and Brennan, Paul and Brown, Nathan and Chapman, Tim and Drysdale, Martin and Gilbert, Ian H. and Hoelder, Swen and Jordan, Allan and Ley, Steven V. and Merritt, Andy and Miller, David and Swarbrick, Martin E. and Wyatt, Paul G.},
doi = {10.1016/j.drudis.2013.07.011},
journal = {Drug discovery today},
number = {23-24}
}
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