@article{mottl-link_erythrocytes_1998,
	title = {Erythrocytes and proinflammatory mediators in wound drainage},
	volume = {75},
	issn = {0042-9007},
	abstract = {BACKGROUND AND OBJECTIVES: Retransfusion of shed blood collected after operation has become popular, but recent reports of side effects led to a search for possible causes.
MATERIALS AND METHODS: In a randomized study of 28 patients undergoing total hip arthroplasty, shed blood was collected in Solcotrans, Orth-Evac, and ordinary Redon drainage. Osmotic fragility was measured and electron-microscopic pictures of erythrocytes from selective samples were taken. Serotonin, prostaglandin E2 (PGE2), and histamine were measured with enzyme-linked immunosorbent assays.
RESULTS: Higher osmotic fragility of erythrocytes collected with Solcotrans appeared to be due to ACD which was used only with that system. Serotonin concentrations did not differ significantly. However, there was a great increase in histamine (Solcotrans 477.7, Orth-Evac 344.0, Redon drainage 453.1 nmol/ml) and PGE2 (Solcotrans 1,908.3, Orth-Evac 1,225.0, Redon drainage 2,666.7 microgram/ml) in shed blood compared with venous blood (histamine 9.5 nmol/l, PGE2 4.2 microgram/ml).
CONCLUSION: Unwashed wound drainage blood collected after operation contains levels of proinflammatory mediators that can account for the reported side effects.},
	language = {eng},
	number = {3},
	journal = {Vox Sanguinis},
	author = {Mottl-Link, S. and Russlies, M. and Klinger, M. and Seyfarth, M. and Ascherl, R. and Gradinger, R.},
	year = {1998},
	pmid = {9852408},
	keywords = {Aged, Arthroplasty, Replacement, Hip, Blood Transfusion, Autologous, Citric Acid, Dinoprostone, Drainage, Erythrocytes, Female, Filtration, Glucose, Histamine, Humans, Male, Middle Aged, Osmotic Fragility, Serotonin, Wounds and Injuries},
	pages = {205--211}
}

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Osmotic fragility was measured and electron-microscopic pictures of erythrocytes from selective samples were taken. Serotonin, prostaglandin E2 (PGE2), and histamine were measured with enzyme-linked immunosorbent assays. RESULTS: Higher osmotic fragility of erythrocytes collected with Solcotrans appeared to be due to ACD which was used only with that system. Serotonin concentrations did not differ significantly. However, there was a great increase in histamine (Solcotrans 477.7, Orth-Evac 344.0, Redon drainage 453.1 nmol/ml) and PGE2 (Solcotrans 1,908.3, Orth-Evac 1,225.0, Redon drainage 2,666.7 microgram/ml) in shed blood compared with venous blood (histamine 9.5 nmol/l, PGE2 4.2 microgram/ml). CONCLUSION: Unwashed wound drainage blood collected after operation contains levels of proinflammatory mediators that can account for the reported side effects.","language":"eng","number":"3","journal":"Vox Sanguinis","author":[{"propositions":[],"lastnames":["Mottl-Link"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Russlies"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Klinger"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Seyfarth"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Ascherl"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Gradinger"],"firstnames":["R."],"suffixes":[]}],"year":"1998","pmid":"9852408","keywords":"Aged, Arthroplasty, Replacement, Hip, Blood Transfusion, Autologous, Citric Acid, Dinoprostone, Drainage, Erythrocytes, Female, Filtration, Glucose, Histamine, Humans, Male, Middle Aged, Osmotic Fragility, Serotonin, Wounds and Injuries","pages":"205–211","bibtex":"@article{mottl-link_erythrocytes_1998,\n\ttitle = {Erythrocytes and proinflammatory mediators in wound drainage},\n\tvolume = {75},\n\tissn = {0042-9007},\n\tabstract = {BACKGROUND AND OBJECTIVES: Retransfusion of shed blood collected after operation has become popular, but recent reports of side effects led to a search for possible causes.\nMATERIALS AND METHODS: In a randomized study of 28 patients undergoing total hip arthroplasty, shed blood was collected in Solcotrans, Orth-Evac, and ordinary Redon drainage. Osmotic fragility was measured and electron-microscopic pictures of erythrocytes from selective samples were taken. Serotonin, prostaglandin E2 (PGE2), and histamine were measured with enzyme-linked immunosorbent assays.\nRESULTS: Higher osmotic fragility of erythrocytes collected with Solcotrans appeared to be due to ACD which was used only with that system. Serotonin concentrations did not differ significantly. However, there was a great increase in histamine (Solcotrans 477.7, Orth-Evac 344.0, Redon drainage 453.1 nmol/ml) and PGE2 (Solcotrans 1,908.3, Orth-Evac 1,225.0, Redon drainage 2,666.7 microgram/ml) in shed blood compared with venous blood (histamine 9.5 nmol/l, PGE2 4.2 microgram/ml).\nCONCLUSION: Unwashed wound drainage blood collected after operation contains levels of proinflammatory mediators that can account for the reported side effects.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Vox Sanguinis},\n\tauthor = {Mottl-Link, S. and Russlies, M. and Klinger, M. and Seyfarth, M. and Ascherl, R. and Gradinger, R.},\n\tyear = {1998},\n\tpmid = {9852408},\n\tkeywords = {Aged, Arthroplasty, Replacement, Hip, Blood Transfusion, Autologous, Citric Acid, Dinoprostone, Drainage, Erythrocytes, Female, Filtration, Glucose, Histamine, Humans, Male, Middle Aged, Osmotic Fragility, Serotonin, Wounds and Injuries},\n\tpages = {205--211}\n}\n\n","author_short":["Mottl-Link, S.","Russlies, M.","Klinger, M.","Seyfarth, M.","Ascherl, R.","Gradinger, R."],"key":"mottl-link_erythrocytes_1998","id":"mottl-link_erythrocytes_1998","bibbaseid":"mottllink-russlies-klinger-seyfarth-ascherl-gradinger-erythrocytesandproinflammatorymediatorsinwounddrainage-1998","role":"author","urls":{},"keyword":["Aged","Arthroplasty","Replacement","Hip","Blood Transfusion","Autologous","Citric Acid","Dinoprostone","Drainage","Erythrocytes","Female","Filtration","Glucose","Histamine","Humans","Male","Middle Aged","Osmotic Fragility","Serotonin","Wounds and Injuries"],"downloads":0},"search_terms":["erythrocytes","proinflammatory","mediators","wound","drainage","mottl-link","russlies","klinger","seyfarth","ascherl","gradinger"],"keywords":["aged","arthroplasty","replacement","hip","blood transfusion","autologous","citric acid","dinoprostone","drainage","erythrocytes","female","filtration","glucose","histamine","humans","male","middle aged","osmotic fragility","serotonin","wounds and injuries"],"authorIDs":[],"dataSources":["nGDaM3ijM4PbPdhb7"]}