Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection. Moyo-Gwete, T., Richardson, S. I., Keeton, R., Hermanus, T., Spencer, H., Manamela, N. P., Ayres, F., Makhado, Z., Motlou, T., Tincho, M. B., Benede, N., Ngomti, A., Baguma, R., Chauke, M. V., Mennen, M., Adriaanse, M., Skelem, S., Goga, A., Garrett, N., Bekker, L., Gray, G., Ntusi, N. A. B., Riou, C., Burgers, W. A., & Moore, P. L. PLOS Pathogens, 19(11):e1011772, Public Library of Science, nov, 2023. ![Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The impact of previous SARS-CoV-2 infection on the durability of Ad26.COV2.S vaccine-elicited responses, and the effect of homologous boosting has not been well explored. We followed a cohort of healthcare workers for 6 months after receiving the Ad26.COV2.S vaccine and a further one month after they received an Ad26.COV2.S booster dose. We assessed longitudinal spike-specific antibody and T cell responses in individuals who had never had SARS-CoV-2 infection, compared to those who were infected with either the D614G or Beta variants prior to vaccination. Antibody and T cell responses elicited by the primary dose were durable against several variants of concern over the 6 month follow-up period, regardless of infection history. However, at 6 months after first vaccination, antibody binding, neutralization and ADCC were as much as 59-fold higher in individuals with hybrid immunity compared to those with no prior infection. Antibody cross-reactivity profiles of the previously infected groups were similar at 6 months, unlike at earlier time points, suggesting that the effect of immune imprinting diminishes by 6 months. Importantly, an Ad26.COV2.S booster dose increased the magnitude of the antibody response in individuals with no prior infection to similar levels as those with previous infection. The magnitude of spike T cell responses and proportion of T cell responders remained stable after homologous boosting, concomitant with a significant increase in long-lived early differentiated CD4 memory T cells. Thus, these data highlight that multiple antigen exposures, whether through infection and vaccination or vaccination alone, result in similar boosts after Ad26.COV2.S vaccination.
@article{Moyo-Gwete2023a,
abstract = {The impact of previous SARS-CoV-2 infection on the durability of Ad26.COV2.S vaccine-elicited responses, and the effect of homologous boosting has not been well explored. We followed a cohort of healthcare workers for 6 months after receiving the Ad26.COV2.S vaccine and a further one month after they received an Ad26.COV2.S booster dose. We assessed longitudinal spike-specific antibody and T cell responses in individuals who had never had SARS-CoV-2 infection, compared to those who were infected with either the D614G or Beta variants prior to vaccination. Antibody and T cell responses elicited by the primary dose were durable against several variants of concern over the 6 month follow-up period, regardless of infection history. However, at 6 months after first vaccination, antibody binding, neutralization and ADCC were as much as 59-fold higher in individuals with hybrid immunity compared to those with no prior infection. Antibody cross-reactivity profiles of the previously infected groups were similar at 6 months, unlike at earlier time points, suggesting that the effect of immune imprinting diminishes by 6 months. Importantly, an Ad26.COV2.S booster dose increased the magnitude of the antibody response in individuals with no prior infection to similar levels as those with previous infection. The magnitude of spike T cell responses and proportion of T cell responders remained stable after homologous boosting, concomitant with a significant increase in long-lived early differentiated CD4 memory T cells. Thus, these data highlight that multiple antigen exposures, whether through infection and vaccination or vaccination alone, result in similar boosts after Ad26.COV2.S vaccination.},
author = {Moyo-Gwete, Thandeka and Richardson, Simone I. and Keeton, Roanne and Hermanus, Tandile and Spencer, Holly and Manamela, Nelia P. and Ayres, Frances and Makhado, Zanele and Motlou, Thopisang and Tincho, Marius B. and Benede, Ntombi and Ngomti, Amkele and Baguma, Richard and Chauke, Masego V. and Mennen, Mathilda and Adriaanse, Marguerite and Skelem, Sango and Goga, Ameena and Garrett, Nigel and Bekker, Linda-Gail and Gray, Glenda and Ntusi, Ntobeko A. B. and Riou, Catherine and Burgers, Wendy A. and Moore, Penny L.},
doi = {10.1371/JOURNAL.PPAT.1011772},
editor = {Silvestri, Guido},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Moyo-Gwete et al. - 2023 - Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, bu(2).pdf:pdf},
isbn = {1111111111},
issn = {1553-7374},
journal = {PLOS Pathogens},
keywords = {Antibodies,Antibody response,Booster doses,Cell differentiation,Cytotoxic T cells,Immune response,OA,OA{\_}PMC,SARS CoV 2,Vaccination and immunization,fund{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,original},
month = {nov},
number = {11},
pages = {e1011772},
pmid = {37943890},
publisher = {Public Library of Science},
title = {{Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection}},
url = {https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011772},
volume = {19},
year = {2023}
}
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