Abstract 7266: VGLL4 is the target of the 3p25 homozygous deletion and presents a novel therapeutic vulnerability for TEAD1/4 but not TEAD1 inhibitors

Abstract 7266: VGLL4 is the target of the 3p25 homozygous deletion and presents a novel therapeutic vulnerability for TEAD1/4 but not TEAD1 inhibitors. Muller, F., Kunnimalaiyaan, S., Mangrolia, P., & Olson, J. Cancer Research, 84(6_Supplement):7266–7266, March, 2024.

Paper doi abstract bibtex

The family of four TEAD transcription factors drive execution of the Hippo pathway and TEAD inhibitors have been developed which show strong anti-proliferative activity in vitro and in vivo but the genetic alterations that best identify responder populations have yet to be fully clarified.

@article{muller_abstract_2024,
	title = {Abstract 7266: \textit{{VGLL4}} is the target of the 3p25 homozygous deletion and presents a novel therapeutic vulnerability for {TEAD1}/4 but not {TEAD1} inhibitors},
	volume = {84},
	issn = {1538-7445},
	shorttitle = {Abstract 7266},
	url = {https://aacrjournals.org/cancerres/article/84/6_Supplement/7266/739731/Abstract-7266-VGLL4-is-the-target-of-the-3p25},
	doi = {10.1158/1538-7445.AM2024-7266},
	abstract = {The family of four TEAD transcription factors drive execution of the Hippo pathway and TEAD inhibitors have been developed which show strong anti-proliferative activity in vitro and in vivo but the genetic alterations that best identify responder populations have yet to be fully clarified.},
	language = {en},
	number = {6\_Supplement},
	urldate = {2024-10-27},
	journal = {Cancer Research},
	author = {Muller, Florian and Kunnimalaiyaan, Selvi and Mangrolia, Parth and Olson, Jill},
	month = mar,
	year = {2024},
	pages = {7266--7266},
}

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