Pregnancy and neonatal outcomes of COVID-19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries. Mullins, E., Hudak, M. L., Banerjee, J., Getzlaff, T., Townson, J., Barnette, K., Playle, R., Perry, A., Bourne, T., Lees, C. C., Nallapeta, S., Mills, E., Peers, B., Stables, S., Iliodromiti, S., Armstrong, M., Owen, H., Mccooty, S., Asghar, A., Mutema, E., Tanton, E., Syson, J., Thornton, D., Goddard, J., Goddard, J., Romero, E., Bray, M., Bourke, M., Trepte, L., Cresswell, J., Balling, T., Atkinson, V., Ajay, B., Margarit, L., Toure, S., Windsor, L., Wixted, D., Zill-E-Huma, R., Vasu, V., Woodward, Z., Hammond, B., Hassan, W., Gada, R., Mason, N., Midwif, C., Emmet, L., Chapman, L., Coxon, S., Moller-Christensen, C., Jaleel, S., Harrington, S. C., Davies, R., Knight, C., Revell, K., Nejad, A., Amin, A., Aladangady, N., Sherris, L., Mullins, E., Mansfield, R., Raven, J. L., Martin, H., Wyatt, C., Robinson, K., Javaid, M., Sukrutha, V., Mahdi, A., Fayadh, A., Swaminathan, L., Ratcliffe, S., Gbinigie, H., Kausar, S., Harrington, A., Southam, D., Lear, E., Kousar, R., Mead, J., Black, M., Crawford, I., Viner, A., Nicoll, A., Harris, L., Bale, N., Rather, B., Essien, S., Gowans, S., Huson, C., Huson, C., Barker, K., Cantliffe, J., Mossop, J., Newport, R., Susara Blunden, R. M., Garner, Z., Higgins, S., Lee, F., Watkins, K., Tipper, J., Anderson, M., Everden, C., Bressington, C., Rand, A., Shah, N., Jokhi, R., Rajeswary, J., Millward, H., Mackay, A., Khunda, A., Co-PI is Kim Hinshaw, A. A., O'Brien, C., McKeown, G., Bishop, L., Robinson, S., Greer, S., Heal, C., Gorti, M., Jones, S., Anim-Somuah, M., Jarvie, W. E., Camarasa, L., Murtha, V., Wee, L., Kidwai, S., Churchill, D., Cloherty, K., Flood, C., Ekladios, S., Kermack, A., Malarselvi, M., Giri, V., Liebling, R., Satodia, P., Radford, J., Chester, M., Khare, M., Wu, P., Halawa, S., Perkins, D., Arya, R., Narayanan, S., Sinha, B., Meadows, E., Grindey, J., Brain, J., Verma, A., Collins, E., Shah, A., Pandey, B., Hughes, R., Dooks, E., James, T., Tarft, H., Daniels, A., Parrott, M., Newman, T., Thomas, A., Davies, S., Hollins, M., Woodhead, A., Takacs, F., Stoddard, E., Rhead, K., Eedle, J., Frankland, L., Home, M., Holroyd, K., Sutton-Cole, A., Keeping, V., Singh, N., West, A., Kelly-Baxter, M., Barker-Williams, K., Jennings, J., Upson, G., Pike, J., Creeth, A., Grice, A., Sellers, H., Johnson, S., Rand, J., Hazelton, T., Hoole, L., Taylor, S., Parlapalli, S., Clarke, G., Gross-Gibbs, K., Edwards, A., Smith, C., Grant, R., Truslove, T., Lewin, A., Arias, A. M., Dunham, T., Willis, L., Mathew, A., Bowdler-Hayes, M., Perry, A., Goodier, J., Jenkins, E., Keable, J., Goodwin, G., Clark, K., Maternity, K., Earnshaw, J., Wagstff, J., Saad, C., Holt, S., Hadlow, P., Hyslop, M., Ambler, S. J., Virdee, S., Mphansi, E., Pepper, S., Dixon, C., Castle, G., Clare, E., Paulose, M., Campbell, C., Coke, L., Alvarez, M., Hardy, R., Govind, A., Ramshaw, A., Carpenter, J., Morries, K., Ashbrook-Raby, C., Anderson, H., Hodgen, L., Buck, L., Newport, R., Grigsby, S., Glyn-Jones, L., Chapman, L., Dorning, A., Blake, C., Pyart, E., Black, G., Burnard, S., Morgan, H., Henry, L., Gill, M., Kenny, T., O'Brien, K., Harwood, H., Parish, G., Jukes, K., Thompson, F., Haslam, Z., Hake, D., Bennett, S., Maher, S., Watkins, E., Ruding, E., Vigni, D., Lal, K., Yelnoorkar, F., Riches, J., Staines, N., Coton, Z., Devison, L., Marshall, C., Netherton, K., Lever, E., Wellstead, S., O'Leary, L., Watts, R., Hannington, R. L. A., Brewer, F., Prince, C., Miller, S., Patterson, M., O'Rourke, A., Hollands, H., Cope, V., Roughley, L., Durnea, U., Maudlin, L., Riddles, L., Cannons, V., Townsend, K., Williams, C., Evans, M., Wood, D., Elliott, K., & Ingham, J. Ultrasound in Obstetrics & Gynecology, 57(4):573–581, April, 2021. Publisher: John Wiley & Sons, Ltd
Pregnancy and neonatal outcomes of COVID-19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries [link]Paper  doi  abstract   bibtex   
Objective: Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and Global Pregnancy and Neonatal outcomes in COVID-19 (PAN-COVID) study and the American Academy of Pediatrics (AAP) Section on Neonatal–Perinatal Medicine (SONPM) National Perinatal COVID-19 Registry. Methods: This was an analysis of data from the PAN-COVID registry (1 January to 25 July 2020), which includes pregnancies with suspected or confirmed maternal SARS-CoV-2 infection at any stage in pregnancy, and the AAP-SONPM National Perinatal COVID-19 registry (4 April to 8 August 2020), which includes pregnancies with positive maternal testing for SARS-CoV-2 from 14 days before delivery to 3 days after delivery. The registries collected data on maternal, fetal, perinatal and neonatal outcomes. The PAN-COVID results are presented overall for pregnancies with suspected or confirmed SARS-CoV-2 infection and separately in those with confirmed infection. Results: We report on 4005 pregnant women with suspected or confirmed SARS-CoV-2 infection (1606 from PAN-COVID and 2399 from AAP-SONPM). For obstetric outcomes, in PAN-COVID overall and in those with confirmed infection in PAN-COVID and AAP-SONPM, respectively, maternal death occurred in 0.5%, 0.5% and 0.2% of cases, early neonatal death in 0.2%, 0.3% and 0.3% of cases and stillbirth in 0.5%, 0.6% and 0.4% of cases. Delivery was preterm (\textless 37 weeks' gestation) in 12.0% of all women in PAN-COVID, in 16.1% of those women with confirmed infection in PAN-COVID and in 15.7% of women in AAP-SONPM. Extreme preterm delivery (\textless 27 weeks' gestation) occurred in 0.5% of cases in PAN-COVID and 0.3% in AAP-SONPM. Neonatal SARS-CoV-2 infection was reported in 0.9% of all deliveries in PAN-COVID overall, in 2.0% in those with confirmed infection in PAN-COVID and in 1.8% in AAP-SONPM; the proportions of neonates tested were 9.5%, 20.7% and 87.2%, respectively. The rates of a small-for-gestational-age (SGA) neonate were 8.2% in PAN-COVID overall, 9.7% in those with confirmed infection and 9.6% in AAP-SONPM. Mean gestational-age-adjusted birth-weight Z-scores were −0.03 in PAN-COVID and −0.18 in AAP-SONPM. Conclusions: The findings from the UK and USA registries of pregnancies with SARS-CoV-2 infection were remarkably concordant. Preterm delivery affected a higher proportion of women than expected based on historical and contemporaneous national data. The proportions of pregnancies affected by stillbirth, a SGA infant or early neonatal death were comparable to those in historical and contemporaneous UK and USA data. Although maternal death was uncommon, the rate was higher than expected based on UK and USA population data, which is likely explained by underascertainment of women affected by milder or asymptomatic infection in pregnancy in the PAN-COVID study, although not in the AAP-SONPM study. The data presented support strong guidance for enhanced precautions to prevent SARS-CoV-2 infection in pregnancy, particularly in the context of increased risks of preterm delivery and maternal mortality, and for priority vaccination of pregnant women and women planning pregnancy. Copyright © 2021 ISUOG. Published by John Wiley & Sons Ltd.
@article{mullins_pregnancy_2021,
	title = {Pregnancy and neonatal outcomes of {COVID}-19: coreporting of common outcomes from {PAN}-{COVID} and {AAP}-{SONPM} registries},
	volume = {57},
	issn = {1469-0705},
	url = {https://onlinelibrary.wiley.com/doi/full/10.1002/uog.23619},
	doi = {10.1002/UOG.23619},
	abstract = {Objective: Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and Global Pregnancy and Neonatal outcomes in COVID-19 (PAN-COVID) study and the American Academy of Pediatrics (AAP) Section on Neonatal–Perinatal Medicine (SONPM) National Perinatal COVID-19 Registry. Methods: This was an analysis of data from the PAN-COVID registry (1 January to 25 July 2020), which includes pregnancies with suspected or confirmed maternal SARS-CoV-2 infection at any stage in pregnancy, and the AAP-SONPM National Perinatal COVID-19 registry (4 April to 8 August 2020), which includes pregnancies with positive maternal testing for SARS-CoV-2 from 14 days before delivery to 3 days after delivery. The registries collected data on maternal, fetal, perinatal and neonatal outcomes. The PAN-COVID results are presented overall for pregnancies with suspected or confirmed SARS-CoV-2 infection and separately in those with confirmed infection. Results: We report on 4005 pregnant women with suspected or confirmed SARS-CoV-2 infection (1606 from PAN-COVID and 2399 from AAP-SONPM). For obstetric outcomes, in PAN-COVID overall and in those with confirmed infection in PAN-COVID and AAP-SONPM, respectively, maternal death occurred in 0.5\%, 0.5\% and 0.2\% of cases, early neonatal death in 0.2\%, 0.3\% and 0.3\% of cases and stillbirth in 0.5\%, 0.6\% and 0.4\% of cases. Delivery was preterm ({\textless} 37 weeks' gestation) in 12.0\% of all women in PAN-COVID, in 16.1\% of those women with confirmed infection in PAN-COVID and in 15.7\% of women in AAP-SONPM. Extreme preterm delivery ({\textless} 27 weeks' gestation) occurred in 0.5\% of cases in PAN-COVID and 0.3\% in AAP-SONPM. Neonatal SARS-CoV-2 infection was reported in 0.9\% of all deliveries in PAN-COVID overall, in 2.0\% in those with confirmed infection in PAN-COVID and in 1.8\% in AAP-SONPM; the proportions of neonates tested were 9.5\%, 20.7\% and 87.2\%, respectively. The rates of a small-for-gestational-age (SGA) neonate were 8.2\% in PAN-COVID overall, 9.7\% in those with confirmed infection and 9.6\% in AAP-SONPM. Mean gestational-age-adjusted birth-weight Z-scores were −0.03 in PAN-COVID and −0.18 in AAP-SONPM. Conclusions: The findings from the UK and USA registries of pregnancies with SARS-CoV-2 infection were remarkably concordant. Preterm delivery affected a higher proportion of women than expected based on historical and contemporaneous national data. The proportions of pregnancies affected by stillbirth, a SGA infant or early neonatal death were comparable to those in historical and contemporaneous UK and USA data. Although maternal death was uncommon, the rate was higher than expected based on UK and USA population data, which is likely explained by underascertainment of women affected by milder or asymptomatic infection in pregnancy in the PAN-COVID study, although not in the AAP-SONPM study. The data presented support strong guidance for enhanced precautions to prevent SARS-CoV-2 infection in pregnancy, particularly in the context of increased risks of preterm delivery and maternal mortality, and for priority vaccination of pregnant women and women planning pregnancy. Copyright © 2021 ISUOG. Published by John Wiley \& Sons Ltd.},
	number = {4},
	urldate = {2021-12-08},
	journal = {Ultrasound in Obstetrics \& Gynecology},
	author = {Mullins, E. and Hudak, M. L. and Banerjee, J. and Getzlaff, T. and Townson, J. and Barnette, K. and Playle, R. and Perry, A. and Bourne, T. and Lees, C. C. and Nallapeta, Soum and Mills, Emma and Peers, Beth and Stables, Sarah and Iliodromiti, Stamatina and Armstrong, Maggie and Owen, Hilary and Mccooty, Shanteela and Asghar, Anila and Mutema, Eric and Tanton, Emma and Syson, Jen and Thornton, Danielle and Goddard, Julie and Goddard, Julie and Romero, Elena and Bray, Maryanne and Bourke, Miriam and Trepte, Lauren and Cresswell, Janet and Balling, Trevor and Atkinson, Vicki and Ajay, Bini and Margarit, Lavinia and Toure, Samirah and Windsor, Laurie and Wixted, Donna and Zill-E-Huma, Rabia and Vasu, Vimal and Woodward, Zoe and Hammond, Beverley and Hassan, Wassim and Gada, Ruta and Mason, Nicky and Midwif, Consultant and Emmet, Louise and Chapman, Lianne and Coxon, Sarah and Moller-Christensen, Christine and Jaleel, Shazia and Harrington, Siân C. and Davies, Ruth and Knight, Caroline and Revell, Kirsty and Nejad, Avideah and Amin, Allison and Aladangady, Narendra and Sherris, Leanne and Mullins, Edward and Mansfield, Roshni and Raven, Jamie Louise and Martin, Hayley and Wyatt, Cheryl and Robinson, Kate and Javaid, Muglu and Sukrutha, Veerareddy and Mahdi, Amy and Fayadh, Anam and Swaminathan, Louise and Ratcliffe, Sam and Gbinigie, Helen and Kausar, Sameena and Harrington, Andrea and Southam, Donna and Lear, Emily and Kousar, Rukhsana and Mead, Joanna and Black, Mairead and Crawford, Isobel and Viner, Alexandra and Nicoll, Antony and Harris, Laura and Bale, Nichola and Rather, Bilal and Essien, Sandra and Gowans, Sharon and Huson, Coralie and Huson, Coralie and Barker, Katie and Cantliffe, Jane and Mossop, Jude and Newport, Rachel and Susara Blunden, R. M. and Garner, Zoe and Higgins, Shelly and Lee, Fidelma and Watkins, Karen and Tipper, Jacqueline and Anderson, Michelle and Everden, Caroline and Bressington, Catherine and Rand, Abby and Shah, Neil and Jokhi, Roobin and Rajeswary, Jyothi and Millward, Helen and Mackay, Ami and Khunda, Aethele and Co-PI is Kim Hinshaw, Amna Ahmed and O'Brien, Clare and McKeown, Gillian and Bishop, Linda and Robinson, Sophie and Greer, Sandra and Heal, Carrie and Gorti, Mahalakshmi and Jones, Sharon and Anim-Somuah, Millicent and Jarvie, Wishaw Eleanor and Camarasa, Laura and Murtha, Victoria and Wee, Ling and Kidwai, Salman and Churchill, David and Cloherty, Karen and Flood, Chris and Ekladios, Sarah and Kermack, Alexandra and Malarselvi, Mani and Giri, Vibha and Liebling, Rachel and Satodia, Prakash and Radford, Jane and Chester, Mark and Khare, Manjiri and Wu, Pendee and Halawa, Sherry and Perkins, Donna and Arya, Rita and Narayanan, Sankara and Sinha, Barkha and Meadows, Emma and Grindey, Julie and Brain, Jessie and Verma, Amit and Collins, Emma and Shah, Ahmar and Pandey, Bhavna and Hughes, Robin and Dooks, Emma and James, Tracy and Tarft, Hayley and Daniels, Allison and Parrott, Megan and Newman, Tabitha and Thomas, Amy and Davies, Sarah and Hollins, Mel and Woodhead, Amy and Takacs, Florentina and Stoddard, Emma and Rhead, Kat and Eedle, Jenny and Frankland, Lisa and Home, Marie and Holroyd, Kelly and Sutton-Cole, Amy and Keeping, Vikki and Singh, Natasha and West, Amy and Kelly-Baxter, Mary and Barker-Williams, Kerry and Jennings, Jacqui and Upson, Gerry and Pike, Joelle and Creeth, Annabel and Grice, Anna and Sellers, Heather and Johnson, Sarah and Rand, James and Hazelton, Tracy and Hoole, Laura and Taylor, Sasha and Parlapalli, Samantha and Clarke, Gayle and Gross-Gibbs, Katherina and Edwards, Alex and Smith, Catherine and Grant, Rachael and Truslove, Tracy and Lewin, Alice and Arias, Ana Maria and Dunham, Tracey and Willis, Louise and Mathew, Asha and Bowdler-Hayes, Melony and Perry, Alison and Goodier, Jenny and Jenkins, Elinor and Keable, Joanna and Goodwin, Gillian and Clark, Katherine and Maternity, Kingston and Earnshaw, Julie and Wagstff, Jayne and Saad, Chloe and Holt, Siobhan and Hadlow, Philippa and Hyslop, Meg and Ambler, Sarah Jayne and Virdee, Sandeep and Mphansi, Eugene and Pepper, Stacey and Dixon, Caroline and Castle, Gail and Clare, Edel and Paulose, Minimol and Campbell, Christine and Coke, Louise and Alvarez, Mary and Hardy, Rachel and Govind, Abha and Ramshaw, Alex and Carpenter, Jodie and Morries, Kimberly and Ashbrook-Raby, Cath and Anderson, Harriet and Hodgen, Lesley and Buck, Lisa and Newport, Rachel and Grigsby, Stephanie and Glyn-Jones, Liz and Chapman, Lianne and Dorning, Ali and Blake, Caroline and Pyart, Eleanor and Black, Georgina and Burnard, Sara and Morgan, Holly and Henry, Lavinia and Gill, Many and Kenny, Tracie and O'Brien, Kirsty and Harwood, Helen and Parish, Gemma and Jukes, Kelly and Thompson, Fiona and Haslam, Zena and Hake, Danielle and Bennett, Sara and Maher, Sarah and Watkins, Eve and Ruding, Elena and Vigni, Denise and Lal, Komal and Yelnoorkar, Fiona and Riches, Jill and Staines, Nikki and Coton, Zoe and Devison, Laura and Marshall, Catherine and Netherton, Kimberley and Lever, Erin and Wellstead, Sue and O'Leary, Lucy and Watts, Rujnita and Hannington, Rachel Liebling Amy and Brewer, Frankie and Prince, Claire and Miller, Sarah and Patterson, Molly and O'Rourke, Anna and Hollands, Heidi and Cope, Vikki and Roughley, Lindsay and Durnea, Uliana and Maudlin, Lucy and Riddles, Laura and Cannons, Viv and Townsend, Kate and Williams, Claire and Evans, Melanie and Wood, Diane and Elliott, Kerry and Ingham, Joanne},
	month = apr,
	year = {2021},
	pmid = {33620113},
	note = {Publisher: John Wiley \& Sons, Ltd},
	keywords = {2, CoV, SARS, coronavirus, fetal growth restriction, outcome, perinatal, preterm delivery, stillbirth},
	pages = {573--581},
}
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