Therapeutic advances in COVID-19. Murakami, N., Hayden, R., Hills, T., Al-Samkari, H., Casey, J., Del Sorbo, L., Lawler, P. R., Sise, M. E., & Leaf, D. E. Nature Reviews. Nephrology, 19(1):38–52, January, 2023. doi abstract bibtex Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed millions of lives. Unlike the early days of the pandemic, when management decisions were based on extrapolations from in vitro data, case reports and case series, clinicians are now equipped with an armamentarium of therapies based on high-quality evidence. These treatments are spread across seven main therapeutic categories: anti-inflammatory agents, antivirals, antithrombotics, therapies for acute hypoxaemic respiratory failure, anti-SARS-CoV-2 (neutralizing) antibody therapies, modulators of the renin-angiotensin-aldosterone system and vitamins. For each of these treatments, the patient population characteristics and clinical settings in which they were studied are important considerations. Although few direct comparisons have been performed, the evidence base and magnitude of benefit for anti-inflammatory and antiviral agents clearly outweigh those of other therapeutic approaches such as vitamins. The emergence of novel variants has further complicated the interpretation of much of the available evidence, particularly for antibody therapies. Importantly, patients with acute and chronic kidney disease were under-represented in many of the COVID-19 clinical trials, and outcomes in this population might differ from those reported in the general population. Here, we examine the clinical evidence for these therapies through a kidney medicine lens.
@article{murakami_therapeutic_2023,
title = {Therapeutic advances in {COVID}-19},
volume = {19},
issn = {1759-507X},
doi = {10.1038/s41581-022-00642-4},
abstract = {Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed millions of lives. Unlike the early days of the pandemic, when management decisions were based on extrapolations from in vitro data, case reports and case series, clinicians are now equipped with an armamentarium of therapies based on high-quality evidence. These treatments are spread across seven main therapeutic categories: anti-inflammatory agents, antivirals, antithrombotics, therapies for acute hypoxaemic respiratory failure, anti-SARS-CoV-2 (neutralizing) antibody therapies, modulators of the renin-angiotensin-aldosterone system and vitamins. For each of these treatments, the patient population characteristics and clinical settings in which they were studied are important considerations. Although few direct comparisons have been performed, the evidence base and magnitude of benefit for anti-inflammatory and antiviral agents clearly outweigh those of other therapeutic approaches such as vitamins. The emergence of novel variants has further complicated the interpretation of much of the available evidence, particularly for antibody therapies. Importantly, patients with acute and chronic kidney disease were under-represented in many of the COVID-19 clinical trials, and outcomes in this population might differ from those reported in the general population. Here, we examine the clinical evidence for these therapies through a kidney medicine lens.},
language = {eng},
number = {1},
journal = {Nature Reviews. Nephrology},
author = {Murakami, Naoka and Hayden, Robert and Hills, Thomas and Al-Samkari, Hanny and Casey, Jonathan and Del Sorbo, Lorenzo and Lawler, Patrick R. and Sise, Meghan E. and Leaf, David E.},
month = jan,
year = {2023},
pmid = {36253508},
pmcid = {PMC9574806},
keywords = {Antiviral Agents, COVID-19, Humans, Pandemics, SARS-CoV-2, Vitamins},
pages = {38--52},
}
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