Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease

Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease. Murueta‐Goyena, A., Del Pino, R., Galdós, M., Arana, B., Acera, M., Carmona‐Abellán, M., Fernández‐Valle, T., Tijero, B., Lucas‐Jiménez, O., Ojeda, N., Ibarretxe‐Bilbao, N., Peña, J., Cortes, J., Ayala, U., Barrenechea, M., Gómez‐Esteban, J. C., & Gabilondo, I. Annals of Neurology, 89(1):165–176, January, 2021.

Paper doi abstract bibtex

Objective This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD). Methods Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K‐ SNCA mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs. Results GCIPL thickness in the parafoveal region (1‐ to 3‐mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls ( p \textless 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10–11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03–10.45, p = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration. Interpretation Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD. ANN NEUROL 2021;89:165–176

@article{muruetagoyena_retinal_2021,
	title = {Retinal {Thickness} {Predicts} the {Risk} of {Cognitive} {Decline} in {Parkinson} {Disease}},
	volume = {89},
	issn = {0364-5134, 1531-8249},
	url = {https://onlinelibrary.wiley.com/doi/10.1002/ana.25944},
	doi = {10.1002/ana.25944},
	abstract = {Objective
              This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD).
            
            
              Methods
              
                Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K‐
                SNCA
                mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs.
              
            
            
              Results
              
                GCIPL thickness in the parafoveal region (1‐ to 3‐mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls (
                p
                 {\textless} 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95\% confidence interval [CI] = 1.10–11.1,
                p
                = 0.03 and RR = 3.28, 95\% CI = 1.03–10.45,
                p
                = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration.
              
            
            
              Interpretation
              Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD. ANN NEUROL 2021;89:165–176},
	language = {en},
	number = {1},
	urldate = {2024-04-15},
	journal = {Annals of Neurology},
	author = {Murueta‐Goyena, Ane and Del Pino, Rocío and Galdós, Marta and Arana, Begoña and Acera, Marian and Carmona‐Abellán, Mar and Fernández‐Valle, Tamara and Tijero, Beatriz and Lucas‐Jiménez, Olaia and Ojeda, Natalia and Ibarretxe‐Bilbao, Naroa and Peña, Javier and Cortes, Jesus and Ayala, Unai and Barrenechea, Maitane and Gómez‐Esteban, Juan Carlos and Gabilondo, Iñigo},
	month = jan,
	year = {2021},
	pages = {165--176},
}

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Methods Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K‐ SNCA mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs. Results GCIPL thickness in the parafoveal region (1‐ to 3‐mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls ( p \\textless 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10–11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03–10.45, p = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration. Interpretation Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD. ANN NEUROL 2021;89:165–176","language":"en","number":"1","urldate":"2024-04-15","journal":"Annals of Neurology","author":[{"propositions":[],"lastnames":["Murueta‐Goyena"],"firstnames":["Ane"],"suffixes":[]},{"propositions":[],"lastnames":["Del","Pino"],"firstnames":["Rocío"],"suffixes":[]},{"propositions":[],"lastnames":["Galdós"],"firstnames":["Marta"],"suffixes":[]},{"propositions":[],"lastnames":["Arana"],"firstnames":["Begoña"],"suffixes":[]},{"propositions":[],"lastnames":["Acera"],"firstnames":["Marian"],"suffixes":[]},{"propositions":[],"lastnames":["Carmona‐Abellán"],"firstnames":["Mar"],"suffixes":[]},{"propositions":[],"lastnames":["Fernández‐Valle"],"firstnames":["Tamara"],"suffixes":[]},{"propositions":[],"lastnames":["Tijero"],"firstnames":["Beatriz"],"suffixes":[]},{"propositions":[],"lastnames":["Lucas‐Jiménez"],"firstnames":["Olaia"],"suffixes":[]},{"propositions":[],"lastnames":["Ojeda"],"firstnames":["Natalia"],"suffixes":[]},{"propositions":[],"lastnames":["Ibarretxe‐Bilbao"],"firstnames":["Naroa"],"suffixes":[]},{"propositions":[],"lastnames":["Peña"],"firstnames":["Javier"],"suffixes":[]},{"propositions":[],"lastnames":["Cortes"],"firstnames":["Jesus"],"suffixes":[]},{"propositions":[],"lastnames":["Ayala"],"firstnames":["Unai"],"suffixes":[]},{"propositions":[],"lastnames":["Barrenechea"],"firstnames":["Maitane"],"suffixes":[]},{"propositions":[],"lastnames":["Gómez‐Esteban"],"firstnames":["Juan","Carlos"],"suffixes":[]},{"propositions":[],"lastnames":["Gabilondo"],"firstnames":["Iñigo"],"suffixes":[]}],"month":"January","year":"2021","pages":"165–176","bibtex":"@article{muruetagoyena_retinal_2021,\n\ttitle = {Retinal {Thickness} {Predicts} the {Risk} of {Cognitive} {Decline} in {Parkinson} {Disease}},\n\tvolume = {89},\n\tissn = {0364-5134, 1531-8249},\n\turl = {https://onlinelibrary.wiley.com/doi/10.1002/ana.25944},\n\tdoi = {10.1002/ana.25944},\n\tabstract = {Objective\n This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD).\n \n \n Methods\n \n Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K‐\n SNCA\n mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell–inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs.\n \n \n \n Results\n \n GCIPL thickness in the parafoveal region (1‐ to 3‐mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63μm in iPD patients and 0.23μm in controls (\n p\n {\\textless} 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95\\% confidence interval [CI] = 1.10–11.1,\n p\n = 0.03 and RR = 3.28, 95\\% CI = 1.03–10.45,\n p\n = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration.\n \n \n \n Interpretation\n Our results provide evidence of the potential use of optical coherence tomography–measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD. ANN NEUROL 2021;89:165–176},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2024-04-15},\n\tjournal = {Annals of Neurology},\n\tauthor = {Murueta‐Goyena, Ane and Del Pino, Rocío and Galdós, Marta and Arana, Begoña and Acera, Marian and Carmona‐Abellán, Mar and Fernández‐Valle, Tamara and Tijero, Beatriz and Lucas‐Jiménez, Olaia and Ojeda, Natalia and Ibarretxe‐Bilbao, Naroa and Peña, Javier and Cortes, Jesus and Ayala, Unai and Barrenechea, Maitane and Gómez‐Esteban, Juan Carlos and Gabilondo, Iñigo},\n\tmonth = jan,\n\tyear = {2021},\n\tpages = {165--176},\n}\n\n","author_short":["Murueta‐Goyena, A.","Del Pino, R.","Galdós, M.","Arana, B.","Acera, M.","Carmona‐Abellán, M.","Fernández‐Valle, T.","Tijero, B.","Lucas‐Jiménez, O.","Ojeda, N.","Ibarretxe‐Bilbao, N.","Peña, J.","Cortes, J.","Ayala, U.","Barrenechea, M.","Gómez‐Esteban, J. C.","Gabilondo, I."],"key":"muruetagoyena_retinal_2021","id":"muruetagoyena_retinal_2021","bibbaseid":"muruetagoyena-delpino-galds-arana-acera-carmonaabelln-fernndezvalle-tijero-etal-retinalthicknesspredictstheriskofcognitivedeclineinparkinsondisease-2021","role":"author","urls":{"Paper":"https://onlinelibrary.wiley.com/doi/10.1002/ana.25944"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://raw.githubusercontent.com/ifiriondo/BilbaoLab/master/_data/biblio.bib","dataSources":["Pqows7JgKbbtLJBZD"],"keywords":[],"search_terms":["retinal","thickness","predicts","risk","cognitive","decline","parkinson","disease","murueta‐goyena","del pino","galdós","arana","acera","carmona‐abellán","fernández‐valle","tijero","lucas‐jiménez","ojeda","ibarretxe‐bilbao","peña","cortes","ayala","barrenechea","gómez‐esteban","gabilondo"],"title":"Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease","year":2021}