Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses. Musaigwa, F., Donald Kamdem, S., Mpotje, T., Mosala, P., Abdel Aziz, N., Herbert, B. R, Brombacher, F., & Komguep Nono, J. PLOS Pathogens, 18(2):e1010327, Public Library of Science, feb, 2022. ![Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic schistosomiasis on the sustainability of vaccine-induced immunity in both children living in endemic areas and experimental infections in mice. Data show that chronic Schistosoma mansoni infection impaired the persistence of vaccine specific antibody responses in poliovirus-vaccinated humans and mice. Mechanistically, schistosomiasis primarily fostered plasmablast and plasma cell death in the bone marrow and removal of parasites following praziquantel treatment reversed the observed cell death and partially restored vaccine-induced memory responses associated with increased serum anti-polio antibody responses. Our findings strongly suggest a previously unrecognized mechanism to explain how chronic schistosomiasis interferes with an otherwise effective vaccine regimen and further advocates for therapeutic intervention strategies that reduce schistosomiasis burden in endemic areas prior to vaccination.
@article{Musaigwa2022,
abstract = {Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic schistosomiasis on the sustainability of vaccine-induced immunity in both children living in endemic areas and experimental infections in mice. Data show that chronic Schistosoma mansoni infection impaired the persistence of vaccine specific antibody responses in poliovirus-vaccinated humans and mice. Mechanistically, schistosomiasis primarily fostered plasmablast and plasma cell death in the bone marrow and removal of parasites following praziquantel treatment reversed the observed cell death and partially restored vaccine-induced memory responses associated with increased serum anti-polio antibody responses. Our findings strongly suggest a previously unrecognized mechanism to explain how chronic schistosomiasis interferes with an otherwise effective vaccine regimen and further advocates for therapeutic intervention strategies that reduce schistosomiasis burden in endemic areas prior to vaccination.},
author = {Musaigwa, Fungai and {Donald Kamdem}, Severin and Mpotje, Thabo and Mosala, Paballo and {Abdel Aziz}, Nada and Herbert, Broski R and Brombacher, Frank and {Komguep Nono}, Justin},
doi = {10.1371/JOURNAL.PPAT.1010327},
editor = {Nair, Meera Goh},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Musaigwa et al. - 2022 - Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the.pdf:pdf},
isbn = {1111111111},
issn = {1553-7374},
journal = {PLOS Pathogens},
keywords = {B cells,Bone marrow cells,OA,Parasitic diseases,Plasma cells,Schistosoma mansoni,Schistosomiasis,Spleen,Vaccination and immunization,fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,original},
month = {feb},
number = {2},
pages = {e1010327},
pmid = {35157732},
publisher = {Public Library of Science},
title = {{Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses}},
url = {https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010327},
volume = {18},
year = {2022}
}
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