Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART. Musinguzi, N., Stanford, F., Boatin, A., Orrell, C., Asiimwe, S., Siedner, M., Haberer, J., Bwana, B., Amanyire, G., Matthews, L., Hedt-Gauthier, B., & Bangsberg, D. International Journal of Obesity, 45(8):1855–1859, 2021.
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Background: Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear. Methods: Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m2) with adherence was assessed among nonpregnant participants with CD4 \textgreater 350 cells/mm3 using fractional regression modeling. Results: Among 322 participants, median age was 32 years, 70% were female, and 54% were from Uganda. Prevalence of obesity was 12% in Uganda and 28% in South Africa. Mean overall cART adherence was 83% in Uganda and 66% in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6% (p = 0.44) in Uganda and +11.4% (p = 0.02) in South Africa. Conclusion: Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.
@article{Musinguzi2021,
abstract = {Background: Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear. Methods: Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m2) with adherence was assessed among nonpregnant participants with CD4 {\textgreater} 350 cells/mm3 using fractional regression modeling. Results: Among 322 participants, median age was 32 years, 70{\%} were female, and 54{\%} were from Uganda. Prevalence of obesity was 12{\%} in Uganda and 28{\%} in South Africa. Mean overall cART adherence was 83{\%} in Uganda and 66{\%} in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6{\%} (p = 0.44) in Uganda and +11.4{\%} (p = 0.02) in South Africa. Conclusion: Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.},
author = {Musinguzi, N. and Stanford, F.C. and Boatin, A.A. and Orrell, C. and Asiimwe, S. and Siedner, M. and Haberer, J.E. and Bwana, B.M. and Amanyire, G. and Matthews, L.T. and Hedt-Gauthier, B. and Bangsberg, D.R.},
doi = {10.1038/s41366-021-00837-y},
journal = {International Journal of Obesity},
number = {8},
pages = {1855--1859},
title = {{Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART}},
volume = {45},
year = {2021}
}

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