Blood and site of disease inflammatory profiles differ in patients with pericardial tuberculosis and Human Immunodeficiency Virus type 1. Mutavhatsindi, H., Du Bruyn, E., Ruzive, S., Howlett, P., Cerrone, M., Sher, A., Mayer-Barber, K. D, Barber, D. L, Ntsekhe, M., Wilkinson, R. J, & Riou, C. Open Forum Infectious Diseases, 10(3):ofad128, mar, 2023. ![Blood and site of disease inflammatory profiles differ in patients with pericardial tuberculosis and Human Immunodeficiency Virus type 1 [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex 2 Objectives. To better understand the pathogenesis of pericardial tuberculosis (PCTB), we sought to characterize the systemic inflammatory profile in people with human immunodeficiency virus (HIV-1) with latent TB infection (LTBI), pulmonary TB (PTB) and PCTB. Methods. Using Luminex, we measured the concentration of 39 analytes in pericardial fluid (PCF) and paired plasma from 18 PCTB participants, and plasma from 16 LTBI and 20 PTB. Follow-up plasma samples were also obtained from PTB and PCTB participants. HLA-DR expression on Mtb-specific CD4 T cells was measured in baseline samples using flow cytometry. Results. Assessment of the overall systemic inflammatory profile by principal component analysis showed that the inflammatory profile of active TB participants was distinct from the LTBI group, while PTB patients could not be distinguished from those with PCTB. When comparing the inflammatory profile between PCF and paired blood, we found that the concentrations of most analytes (24/39) were elevated at site of disease. However, the inflammatory profile in PCF partially mirrored inflammatory events in the blood. After TB treatment completion, the overall plasma inflammatory profile reverted to those observed in the LTBI group. Lastly, HLA-DR expression showed the best performance for TB diagnosis compared to previously described biosignatures built from soluble markers. Conclusion. Our results show that the inflammatory profile in blood was comparable between PTB and PCTB. However, at the site of infection (PCF), inflammation was significantly elevated compared to blood. Additionally, our data emphasize the potential role of HLA-DR expression as a biomarker for TB diagnosis.
@article{Mutavhatsindi2023,
abstract = {2 Objectives. To better understand the pathogenesis of pericardial tuberculosis (PCTB), we sought to characterize the systemic inflammatory profile in people with human immunodeficiency virus (HIV-1) with latent TB infection (LTBI), pulmonary TB (PTB) and PCTB. Methods. Using Luminex, we measured the concentration of 39 analytes in pericardial fluid (PCF) and paired plasma from 18 PCTB participants, and plasma from 16 LTBI and 20 PTB. Follow-up plasma samples were also obtained from PTB and PCTB participants. HLA-DR expression on Mtb-specific CD4 T cells was measured in baseline samples using flow cytometry. Results. Assessment of the overall systemic inflammatory profile by principal component analysis showed that the inflammatory profile of active TB participants was distinct from the LTBI group, while PTB patients could not be distinguished from those with PCTB. When comparing the inflammatory profile between PCF and paired blood, we found that the concentrations of most analytes (24/39) were elevated at site of disease. However, the inflammatory profile in PCF partially mirrored inflammatory events in the blood. After TB treatment completion, the overall plasma inflammatory profile reverted to those observed in the LTBI group. Lastly, HLA-DR expression showed the best performance for TB diagnosis compared to previously described biosignatures built from soluble markers. Conclusion. Our results show that the inflammatory profile in blood was comparable between PTB and PCTB. However, at the site of infection (PCF), inflammation was significantly elevated compared to blood. Additionally, our data emphasize the potential role of HLA-DR expression as a biomarker for TB diagnosis.},
author = {Mutavhatsindi, Hygon and {Du Bruyn}, Elsa and Ruzive, Sheena and Howlett, Patrick and Cerrone, Maddalena and Sher, Alan and Mayer-Barber, Katrin D and Barber, Daniel L and Ntsekhe, Mpiko and Wilkinson, Robert J and Riou, Catherine},
doi = {10.1093/OFID/OFAD128},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Mutavhatsindi et al. - 2023 - Blood and site of disease inflammatory profiles differ in patients with pericardial tuberculosis and Human.pdf:pdf},
issn = {2328-8957},
journal = {Open Forum Infectious Diseases},
keywords = {Inflammatory profile,OA,Pericardial tuberculosis,diagnosis,fund{\_}ack,original,site of disease,treatment response},
mendeley-tags = {OA,fund{\_}ack,original},
month = {mar},
number = {3},
pages = {ofad128},
title = {{Blood and site of disease inflammatory profiles differ in patients with pericardial tuberculosis and Human Immunodeficiency Virus type 1}},
url = {https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad128/7074136},
volume = {10},
year = {2023}
}
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HLA-DR expression on Mtb-specific CD4 T cells was measured in baseline samples using flow cytometry. Results. Assessment of the overall systemic inflammatory profile by principal component analysis showed that the inflammatory profile of active TB participants was distinct from the LTBI group, while PTB patients could not be distinguished from those with PCTB. When comparing the inflammatory profile between PCF and paired blood, we found that the concentrations of most analytes (24/39) were elevated at site of disease. However, the inflammatory profile in PCF partially mirrored inflammatory events in the blood. After TB treatment completion, the overall plasma inflammatory profile reverted to those observed in the LTBI group. Lastly, HLA-DR expression showed the best performance for TB diagnosis compared to previously described biosignatures built from soluble markers. Conclusion. Our results show that the inflammatory profile in blood was comparable between PTB and PCTB. 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