Quantitative enantioseparation of amino acids by comprehensive two-dimensional gas chromatography applied to non-terrestrial samples. Myrgorodska, I., Meinert, C., Martins, Z., le Sergeant d’Hendecourt , L., & Meierhenrich, U. J. Journal of Chromatography A, 1433:131--136, February, 2016.
Quantitative enantioseparation of amino acids by comprehensive two-dimensional gas chromatography applied to non-terrestrial samples [link]Paper  doi  abstract   bibtex   
This work presents an improved analytical procedure for the resolution and quantification of amino acid enantiomers by multidimensional gas chromatography. The procedure contains a derivatization step, by which amino acids were transformed into N(O,S)-ethoxycarbonylheptafluorobutyl esters. It was optimized for the resolution of non-proteinogenic amino acids in the matrix of complex non-terrestrial samples. The procedure has proven to be highly sensitive and shows a wide linearity range with 0.005–3 pmol detection limits for quantitative determinations. The developed procedure was tested on a sample of the Murchison meteorite, for which obtained chromatograms show excellent peak resolution, minimal co-elution and peak overlap. We conclude that comprehensive two dimensional chromatography, in combination with the optimized derivatization method is a highly suitable technique for the analysis of samples with very limited quantities and containing potentially prebiotic molecules, such as interstellar ice analogs and meteorites.
@article{myrgorodska_quantitative_2016,
	title = {Quantitative enantioseparation of amino acids by comprehensive two-dimensional gas chromatography applied to non-terrestrial samples},
	volume = {1433},
	issn = {0021-9673},
	url = {http://www.sciencedirect.com/science/article/pii/S0021967316000467},
	doi = {10.1016/j.chroma.2016.01.014},
	abstract = {This work presents an improved analytical procedure for the resolution and quantification of amino acid enantiomers by multidimensional gas chromatography. The procedure contains a derivatization step, by which amino acids were transformed into N(O,S)-ethoxycarbonylheptafluorobutyl esters. It was optimized for the resolution of non-proteinogenic amino acids in the matrix of complex non-terrestrial samples. The procedure has proven to be highly sensitive and shows a wide linearity range with 0.005–3 pmol detection limits for quantitative determinations. The developed procedure was tested on a sample of the Murchison meteorite, for which obtained chromatograms show excellent peak resolution, minimal co-elution and peak overlap. We conclude that comprehensive two dimensional chromatography, in combination with the optimized derivatization method is a highly suitable technique for the analysis of samples with very limited quantities and containing potentially prebiotic molecules, such as interstellar ice analogs and meteorites.},
	urldate = {2017-03-30TZ},
	journal = {Journal of Chromatography A},
	author = {Myrgorodska, Iuliia and Meinert, Cornelia and Martins, Zita and le Sergeant d’Hendecourt, Louis and Meierhenrich, Uwe J.},
	month = feb,
	year = {2016},
	keywords = {Amino acids, Enantioseparation, GC × GC, Non-terrestrial samples, chirality},
	pages = {131--136}
}
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