@article{nair_trace_2022,
	title = {Trace {Amine}-{Associated} {Receptor} 1 ({TAAR1}): {Molecular} and {Clinical} {Insights} for the {Treatment} of {Schizophrenia} and {Related} {Comorbidities}},
	volume = {5},
	shorttitle = {Trace {Amine}-{Associated} {Receptor} 1 ({TAAR1})},
	url = {https://doi.org/10.1021/acsptsci.2c00016},
	doi = {10.1021/acsptsci.2c00016},
	abstract = {Schizophrenia is a complex and severe mental illness. Current treatments for schizophrenia typically modulate dopaminergic neurotransmission by D2-receptor blockade. While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments. For the last few decades, discovery efforts have sought nondopaminergic compounds with the aim to effectively treat the broad symptoms of schizophrenia. In this viewpoint, we provide an overview on trace-amine associated receptor-1 (TAAR1), which presents a clinically validated nondopaminergic target for treating schizophrenia and related disorders, with significantly less overall side-effect burden. TAAR1 agonists may also be specifically beneficial for the substance abuse comorbidity and metabolic syndrome that is often present in patients with schizophrenia.},
	number = {3},
	urldate = {2022-07-11},
	journal = {ACS Pharmacology \& Translational Science},
	author = {Nair, Pramod C. and Chalker, Justin M. and McKinnon, Ross A. and Langmead, Christopher J and Gregory, Karen J. and Bastiampillai, Tarun},
	month = mar,
	year = {2022},
	note = {Publisher: American Chemical Society},
	pages = {183--188},
}

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While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments. For the last few decades, discovery efforts have sought nondopaminergic compounds with the aim to effectively treat the broad symptoms of schizophrenia. In this viewpoint, we provide an overview on trace-amine associated receptor-1 (TAAR1), which presents a clinically validated nondopaminergic target for treating schizophrenia and related disorders, with significantly less overall side-effect burden. TAAR1 agonists may also be specifically beneficial for the substance abuse comorbidity and metabolic syndrome that is often present in patients with schizophrenia.","number":"3","urldate":"2022-07-11","journal":"ACS Pharmacology & Translational Science","author":[{"propositions":[],"lastnames":["Nair"],"firstnames":["Pramod","C."],"suffixes":[]},{"propositions":[],"lastnames":["Chalker"],"firstnames":["Justin","M."],"suffixes":[]},{"propositions":[],"lastnames":["McKinnon"],"firstnames":["Ross","A."],"suffixes":[]},{"propositions":[],"lastnames":["Langmead"],"firstnames":["Christopher","J"],"suffixes":[]},{"propositions":[],"lastnames":["Gregory"],"firstnames":["Karen","J."],"suffixes":[]},{"propositions":[],"lastnames":["Bastiampillai"],"firstnames":["Tarun"],"suffixes":[]}],"month":"March","year":"2022","note":"Publisher: American Chemical Society","pages":"183–188","bibtex":"@article{nair_trace_2022,\n\ttitle = {Trace {Amine}-{Associated} {Receptor} 1 ({TAAR1}): {Molecular} and {Clinical} {Insights} for the {Treatment} of {Schizophrenia} and {Related} {Comorbidities}},\n\tvolume = {5},\n\tshorttitle = {Trace {Amine}-{Associated} {Receptor} 1 ({TAAR1})},\n\turl = {https://doi.org/10.1021/acsptsci.2c00016},\n\tdoi = {10.1021/acsptsci.2c00016},\n\tabstract = {Schizophrenia is a complex and severe mental illness. Current treatments for schizophrenia typically modulate dopaminergic neurotransmission by D2-receptor blockade. While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments. For the last few decades, discovery efforts have sought nondopaminergic compounds with the aim to effectively treat the broad symptoms of schizophrenia. In this viewpoint, we provide an overview on trace-amine associated receptor-1 (TAAR1), which presents a clinically validated nondopaminergic target for treating schizophrenia and related disorders, with significantly less overall side-effect burden. TAAR1 agonists may also be specifically beneficial for the substance abuse comorbidity and metabolic syndrome that is often present in patients with schizophrenia.},\n\tnumber = {3},\n\turldate = {2022-07-11},\n\tjournal = {ACS Pharmacology \\& Translational Science},\n\tauthor = {Nair, Pramod C. and Chalker, Justin M. and McKinnon, Ross A. and Langmead, Christopher J and Gregory, Karen J. and Bastiampillai, Tarun},\n\tmonth = mar,\n\tyear = {2022},\n\tnote = {Publisher: American Chemical Society},\n\tpages = {183--188},\n}\n\n","author_short":["Nair, P. C.","Chalker, J. M.","McKinnon, R. A.","Langmead, C. J","Gregory, K. J.","Bastiampillai, T."],"key":"nair_trace_2022","id":"nair_trace_2022","bibbaseid":"nair-chalker-mckinnon-langmead-gregory-bastiampillai-traceamineassociatedreceptor1taar1molecularandclinicalinsightsforthetreatmentofschizophreniaandrelatedcomorbidities-2022","role":"author","urls":{"Paper":"https://doi.org/10.1021/acsptsci.2c00016"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/6447874/collections/AWT385HL/items?key=EzirEtCHddAI8OiL0hFklGbe&format=bibtex&limit=100","dataSources":["eTsH756eicg6vxuG3","Rcf3ThCgN7ShBuzJy","tWgPDtt4MHxv5bMax","TZeKmKj6mKcyHY3tK","jEsWEe9RBbgbTMFzt","TvrStsceXSmGoKMJj","z4ASdQSCbDqBhbYkc"],"keywords":[],"search_terms":["trace","amine","associated","receptor","taar1","molecular","clinical","insights","treatment","schizophrenia","related","comorbidities","nair","chalker","mckinnon","langmead","gregory","bastiampillai"],"title":"Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities","year":2022}