@article{RN236,
   author = {Neal, R. E., 2nd and Davalos, R. V.},
   title = {The feasibility of irreversible electroporation for the treatment of breast cancer and other heterogeneous systems},
   journal = {Ann Biomed Eng},
   volume = {37},
   number = {12},
   pages = {2615-25},
   note = {1573-9686
Neal, Robert E 2nd
Davalos, Rafael V
Journal Article
United States
2009/09/17
Ann Biomed Eng. 2009 Dec;37(12):2615-25. doi: 10.1007/s10439-009-9796-9. Epub 2009 Sep 15.},
   abstract = {Developments in breast cancer therapies show potential for replacing simple and radical mastectomies with less invasive techniques. Localized thermal techniques encounter difficulties, preventing their widespread acceptance as replacements for surgical resection. Irreversible electroporation (IRE) is a non-thermal, minimally invasive focal ablation technique capable of killing tissue using electric pulses to create irrecoverable nano-scale pores in the cell membrane. Its unique mechanism of cell death exhibits benefits over thermal techniques including rapid lesion creation and resolution, preservation of the extracellular matrix and major vasculature, and reduced scarring. This study investigates applying IRE to treat primary breast tumors located within a fatty extracellular matrix despite IREs dependence on the heterogeneous properties of tissue. In vitro experiments were performed on MDA-MB-231 human mammary carcinoma cells to determine a baseline electric field threshold (1000 V/cm) to cause IRE for a given set of pulse parameters. The threshold was incorporated into a three-dimensional numerical model of a heterogeneous system to simulate IRE treatments. Treatment-relevant protocols were found to be capable of treating targeted tissue over a large range of heterogeneous properties without inducing significant thermal damage, making IRE a potential modality for successfully treating breast cancer. Information from this study may be used for the investigation of other heterogeneous tissue applications for IRE.},
   keywords = {Breast Neoplasms/pathology/*physiopathology/*therapy
Cell Line, Tumor
Computer Simulation
Electroporation/*methods
Electrosurgery/*methods
Feasibility Studies
Female
Humans
*Models, Biological
Therapy, Computer-Assisted/*methods
Treatment Outcome},
   ISSN = {0090-6964},
   DOI = {10.1007/s10439-009-9796-9},
   year = {2009},
   type = {Journal Article}
}

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Localized thermal techniques encounter difficulties, preventing their widespread acceptance as replacements for surgical resection. Irreversible electroporation (IRE) is a non-thermal, minimally invasive focal ablation technique capable of killing tissue using electric pulses to create irrecoverable nano-scale pores in the cell membrane. Its unique mechanism of cell death exhibits benefits over thermal techniques including rapid lesion creation and resolution, preservation of the extracellular matrix and major vasculature, and reduced scarring. This study investigates applying IRE to treat primary breast tumors located within a fatty extracellular matrix despite IREs dependence on the heterogeneous properties of tissue. In vitro experiments were performed on MDA-MB-231 human mammary carcinoma cells to determine a baseline electric field threshold (1000 V/cm) to cause IRE for a given set of pulse parameters. The threshold was incorporated into a three-dimensional numerical model of a heterogeneous system to simulate IRE treatments. Treatment-relevant protocols were found to be capable of treating targeted tissue over a large range of heterogeneous properties without inducing significant thermal damage, making IRE a potential modality for successfully treating breast cancer. Information from this study may be used for the investigation of other heterogeneous tissue applications for IRE.","keywords":"Breast Neoplasms/pathology/*physiopathology/*therapy Cell Line, Tumor Computer Simulation Electroporation/*methods Electrosurgery/*methods Feasibility Studies Female Humans *Models, Biological Therapy, Computer-Assisted/*methods Treatment Outcome","issn":"0090-6964","doi":"10.1007/s10439-009-9796-9","year":"2009","bibtex":"@article{RN236,\n author = {Neal, R. E., 2nd and Davalos, R. V.},\n title = {The feasibility of irreversible electroporation for the treatment of breast cancer and other heterogeneous systems},\n journal = {Ann Biomed Eng},\n volume = {37},\n number = {12},\n pages = {2615-25},\n note = {1573-9686\nNeal, Robert E 2nd\nDavalos, Rafael V\nJournal Article\nUnited States\n2009/09/17\nAnn Biomed Eng. 2009 Dec;37(12):2615-25. doi: 10.1007/s10439-009-9796-9. Epub 2009 Sep 15.},\n abstract = {Developments in breast cancer therapies show potential for replacing simple and radical mastectomies with less invasive techniques. Localized thermal techniques encounter difficulties, preventing their widespread acceptance as replacements for surgical resection. Irreversible electroporation (IRE) is a non-thermal, minimally invasive focal ablation technique capable of killing tissue using electric pulses to create irrecoverable nano-scale pores in the cell membrane. Its unique mechanism of cell death exhibits benefits over thermal techniques including rapid lesion creation and resolution, preservation of the extracellular matrix and major vasculature, and reduced scarring. This study investigates applying IRE to treat primary breast tumors located within a fatty extracellular matrix despite IREs dependence on the heterogeneous properties of tissue. In vitro experiments were performed on MDA-MB-231 human mammary carcinoma cells to determine a baseline electric field threshold (1000 V/cm) to cause IRE for a given set of pulse parameters. The threshold was incorporated into a three-dimensional numerical model of a heterogeneous system to simulate IRE treatments. Treatment-relevant protocols were found to be capable of treating targeted tissue over a large range of heterogeneous properties without inducing significant thermal damage, making IRE a potential modality for successfully treating breast cancer. 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