@article{RN190,
   author = {Neal, R. E., 2nd and Garcia, P. A. and Kavnoudias, H. and Rosenfeldt, F. and McLean, C. A. and Earl, V. and Bergman, J. and Davalos, R. V. and Thomson, K. R.},
   title = {In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models},
   journal = {IEEE Trans Biomed Eng},
   volume = {62},
   number = {2},
   pages = {561-9},
   note = {1558-2531
Neal, Robert E 2nd
Garcia, Paulo A
Kavnoudias, Helen
Rosenfeldt, Franklin
Mclean, Catriona A
Earl, Victoria
Bergman, Joanne
Davalos, Rafael V
Thomson, Kenneth R
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
2014/09/30
IEEE Trans Biomed Eng. 2015 Feb;62(2):561-9. doi: 10.1109/TBME.2014.2360374. Epub 2014 Sep 25.},
   abstract = {Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electric pulses remain to be characterized. Here, a pulse protocol of 100 electric pulses, each 100 μs long, is delivered at 1 pulse/s to canine kidneys at three different voltage-to-distance ratios while measuring intrapulse current, completed 6 h before humane euthanasia. Numerical models were correlated with lesions and electrical measurements to determine electrical conductivity behavior and lethal electric field threshold. Three methods for modeling tissue response to the pulses were investigated (static, linear dynamic, and asymmetrical sigmoid dynamic), where the asymmetrical sigmoid dynamic conductivity function most accurately and precisely matched lesion dimensions, with a lethal electric field threshold of 575 ± 67 V/cm for the protocols used. The linear dynamic model also attains accurate predictions with a simpler function. These findings can aid renal IRE treatment planning under varying electrode geometries and pulse strengths. Histology showed a wholly necrotic core lesion at the highest electric fields, surrounded by a transitional perimeter of differential tissue viability dependent on renal structure.},
   keywords = {Ablation Techniques/*methods
Animals
Computer Simulation
Dogs
Electroporation/*methods
Kidney/pathology/*surgery
Male
*Models, Biological
Nephrectomy/*methods
Surgery, Computer-Assisted/methods
Treatment Outcome},
   ISSN = {0018-9294},
   DOI = {10.1109/tbme.2014.2360374},
   year = {2015},
   type = {Journal Article}
}

{"_id":"Q8NLMBTW9AJM9YRm2","bibbaseid":"neal-garcia-kavnoudias-rosenfeldt-mclean-earl-bergman-davalos-etal-invivoirreversibleelectroporationkidneyablationexperimentallycorrelatednumericalmodels-2015","author_short":["Neal, R. E.","Garcia, P. A.","Kavnoudias, H.","Rosenfeldt, F.","McLean, C. A.","Earl, V.","Bergman, J.","Davalos, R. V.","Thomson, K. R."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kavnoudias"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Rosenfeldt"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["McLean"],"firstnames":["C.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Earl"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Bergman"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Thomson"],"firstnames":["K.","R."],"suffixes":[]}],"title":"In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models","journal":"IEEE Trans Biomed Eng","volume":"62","number":"2","pages":"561-9","note":"1558-2531 Neal, Robert E 2nd Garcia, Paulo A Kavnoudias, Helen Rosenfeldt, Franklin Mclean, Catriona A Earl, Victoria Bergman, Joanne Davalos, Rafael V Thomson, Kenneth R Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States 2014/09/30 IEEE Trans Biomed Eng. 2015 Feb;62(2):561-9. doi: 10.1109/TBME.2014.2360374. Epub 2014 Sep 25.","abstract":"Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electric pulses remain to be characterized. Here, a pulse protocol of 100 electric pulses, each 100 μs long, is delivered at 1 pulse/s to canine kidneys at three different voltage-to-distance ratios while measuring intrapulse current, completed 6 h before humane euthanasia. Numerical models were correlated with lesions and electrical measurements to determine electrical conductivity behavior and lethal electric field threshold. Three methods for modeling tissue response to the pulses were investigated (static, linear dynamic, and asymmetrical sigmoid dynamic), where the asymmetrical sigmoid dynamic conductivity function most accurately and precisely matched lesion dimensions, with a lethal electric field threshold of 575 ± 67 V/cm for the protocols used. The linear dynamic model also attains accurate predictions with a simpler function. These findings can aid renal IRE treatment planning under varying electrode geometries and pulse strengths. Histology showed a wholly necrotic core lesion at the highest electric fields, surrounded by a transitional perimeter of differential tissue viability dependent on renal structure.","keywords":"Ablation Techniques/*methods Animals Computer Simulation Dogs Electroporation/*methods Kidney/pathology/*surgery Male *Models, Biological Nephrectomy/*methods Surgery, Computer-Assisted/methods Treatment Outcome","issn":"0018-9294","doi":"10.1109/tbme.2014.2360374","year":"2015","bibtex":"@article{RN190,\n author = {Neal, R. E., 2nd and Garcia, P. A. and Kavnoudias, H. and Rosenfeldt, F. and McLean, C. A. and Earl, V. and Bergman, J. and Davalos, R. V. and Thomson, K. R.},\n title = {In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models},\n journal = {IEEE Trans Biomed Eng},\n volume = {62},\n number = {2},\n pages = {561-9},\n note = {1558-2531\nNeal, Robert E 2nd\nGarcia, Paulo A\nKavnoudias, Helen\nRosenfeldt, Franklin\nMclean, Catriona A\nEarl, Victoria\nBergman, Joanne\nDavalos, Rafael V\nThomson, Kenneth R\nJournal Article\nResearch Support, Non-U.S. Gov't\nResearch Support, U.S. Gov't, Non-P.H.S.\nUnited States\n2014/09/30\nIEEE Trans Biomed Eng. 2015 Feb;62(2):561-9. doi: 10.1109/TBME.2014.2360374. Epub 2014 Sep 25.},\n abstract = {Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electric pulses remain to be characterized. Here, a pulse protocol of 100 electric pulses, each 100 μs long, is delivered at 1 pulse/s to canine kidneys at three different voltage-to-distance ratios while measuring intrapulse current, completed 6 h before humane euthanasia. Numerical models were correlated with lesions and electrical measurements to determine electrical conductivity behavior and lethal electric field threshold. Three methods for modeling tissue response to the pulses were investigated (static, linear dynamic, and asymmetrical sigmoid dynamic), where the asymmetrical sigmoid dynamic conductivity function most accurately and precisely matched lesion dimensions, with a lethal electric field threshold of 575 ± 67 V/cm for the protocols used. The linear dynamic model also attains accurate predictions with a simpler function. These findings can aid renal IRE treatment planning under varying electrode geometries and pulse strengths. Histology showed a wholly necrotic core lesion at the highest electric fields, surrounded by a transitional perimeter of differential tissue viability dependent on renal structure.},\n keywords = {Ablation Techniques/*methods\nAnimals\nComputer Simulation\nDogs\nElectroporation/*methods\nKidney/pathology/*surgery\nMale\n*Models, Biological\nNephrectomy/*methods\nSurgery, Computer-Assisted/methods\nTreatment Outcome},\n ISSN = {0018-9294},\n DOI = {10.1109/tbme.2014.2360374},\n year = {2015},\n type = {Journal Article}\n}\n\n","author_short":["Neal, R. E.","Garcia, P. A.","Kavnoudias, H.","Rosenfeldt, F.","McLean, C. A.","Earl, V.","Bergman, J.","Davalos, R. V.","Thomson, K. R."],"key":"RN190","id":"RN190","bibbaseid":"neal-garcia-kavnoudias-rosenfeldt-mclean-earl-bergman-davalos-etal-invivoirreversibleelectroporationkidneyablationexperimentallycorrelatednumericalmodels-2015","role":"author","urls":{},"keyword":["Ablation Techniques/*methods Animals Computer Simulation Dogs Electroporation/*methods Kidney/pathology/*surgery Male *Models","Biological Nephrectomy/*methods Surgery","Computer-Assisted/methods Treatment Outcome"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["ablation techniques/*methods animals computer simulation dogs electroporation/*methods kidney/pathology/*surgery male *models","biological nephrectomy/*methods surgery","computer-assisted/methods treatment outcome"],"search_terms":["vivo","irreversible","electroporation","kidney","ablation","experimentally","correlated","numerical","models","neal","garcia","kavnoudias","rosenfeldt","mclean","earl","bergman","davalos","thomson"],"title":"In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models","year":2015}